Questions and Answers 100% Pass
Updated 2025
DIC - ✔✔hypercoagulation, triggering coag. pathway to be initated inappropriately.
Dx associated with DIC - ✔✔APL, solid metastatic mucinous adenocarcinoma, tumors
of breast, prostate, stomach, lung and pancreas
S/S DIC - ✔✔Bleeding simultaneously from 3 unrelated sites is hallmark sign
Bleeding, acidosis, hematuria, oliguria, dyspnea, hemoptysis, cough, tachypnea,
diminished breath sounds, pleural friction rub, jaundice, petechiae, thrombosis, fever
Treatment of DIC - ✔✔heparin to treat clotting, Amicar to stabilize bleeding, electrolyte
replacement, blood transfusions, oxygen
Lab findings in DIC - ✔✔decreased platelet, increased PT/PTT, decreased fibrinogen,
Microangiopathic Hemolytic Anemia(Schistocytes), Elevated fibrin split products(D-
dimer), D-dimer is an indicator of lysed cross-linked fibrin. Elevated D-dimer is the
BEST test for DIC.
What is TTP - ✔✔Excessive blood clot formation causing thrombocytopenia as platelets
are consumed
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, S/S of TTP - ✔✔purpura, petechiae, pale skin, fatigue, fever, tachycardia, tachypnea,
oliguria
Lab findings in TTP - ✔✔thrombocytopenia, prolonged bleeding time, normal PT and
PTT; Increased bilirubin and LDH; Negative coombs test; decreased ADAMTS13 assay
Malignancies commonly associated with SIADH - ✔✔SCLC, mesothellioma, thymoma,
head & neck; lymphoma, eqing sarcoma; GI (esophageal, pancreatic, stomach,
duodenum); GU (prostate, bladder, ureter); CNS
S/S of mild SIADH - ✔✔Muscle cramps, fatigue, anorexia, N/V, thirst, headache, NA
131-135
S/S of moderate SIADH - ✔✔weight gain, confusion, disoriented, combative, lethargic,
abdominal cramping oliguria, hypoactive reflexes, NA 126-130
S/S of severe SIADH - ✔✔cerebral edema, palpilledema, ataxia, seizure, psychosis,
coma, death, NA < 120
Lab findings in SIADH (serum and urine) - ✔✔Serum: NA decreased (<130), K and
Bicarb normal, phosphorus normal, osmolality- decreased, BUN/CRT may be
decreased
Urine: NA > 20 mEq/L, increased specific gravity, osmolality > 100 mOsm/kg
Treatment of mild SIADH - ✔✔Fluid restriction (500-1000 mL/day); treat malignancy
Treatment of moderate to severe SIADH - ✔✔stabalize severe neurologic symptoms
prior to initiating treatment for underlying cause; fluid restrictions, treat underlying
malignancy
seizure precautions, loop duretics, frequent neuro checks hypertonic saline (3%)
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