©THEBRIGHT 2024/2025 ALL RIGHTS RESERVED 10:15AM A+
NR 565 Midterm Exam Questions And
Answers |Latest 2025 | Guaranteed Pass.
Which schedule drugs can APRNs prescribe? - Answer✔Varies state by state
May include schedule II-V, but never schedule I
Who determines and regulates prescriptive authority? - Answer✔The state's health
professional board
How does limited prescriptive authority impact patients within the healthcare system? -
Answer✔Creates numerous barriers to quality, affordable, and accessible patient care
May prevent outreach to areas of greatest need
Physician approval of prescriptions can increase patient waits
What are the key responsibilities of prescribing? - Answer✔A sound understanding of drugs and
the conditions that they are used to manage
Be deliberate in decision-making process
Do not prescribe for family or friends
Document thorough history and physical for the records, including education provided on drug
Have a documented plan for monitoring and titration
What should be used in making prescribing decisions? - Answer✔Cost, follow current
guidelines, availability, interactions, side effects, allergies, hepatic/renal function, need for
monitoring, special populations
PK and PD changes in older adults and how that affects how you prescribe? - Answer✔Very
high risk of adverse drug reactions and drug-drug interactions
D/t altered PK, multiple and severe illnesses, polypharmacy, poor adherence
Beer's Criteria - Answer✔List of potentially inappropriate medications to use in the older
populations
1
, ©THEBRIGHT 2024/2025 ALL RIGHTS RESERVED 10:15AM A+
Updated annually
Prescribers ultimately decide whether to prescribe or not
Impacts/outcomes of polypharmacy? - Answer✔Increased ADRs and drug-drug interactions
What are CYP450? - Answer✔Enzymes responsible for drug metabolism (biotransformation)-
oxidization, reduction, hydrolyzed to promote renal dug excretion
Hepatic enzyme system, composed of 12 enzyme families
What do CYP450 enzymes do? - Answer✔Promote drug excretion by making them more
"excretable"--hydrophilic/water soluble and charged (ion)
Inactivate drugs, increase therapeutic action through metabolism, activate a prodrug, decrease
drug toxicity
CYP450 inhibitor examples? - Answer✔VISA credit card debt inhibits spending on designers like
CK to look GQ
Valproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconzaole
Grapefruit juice
Quinidine
What do CYP450 inhibitors do? - Answer✔Decrease the rate of metabolism
Act on liver through process of inhibition
Slows rate of metabolism, increases active drug accumulation which can lead to adverse
reactions and drug toxicity
What do CYP450 inhibitors do if not used correctly? - Answer✔Can lead to adverse effects and
drug toxicity
What happens when someone has a poor metabolism phenotype? - Answer✔Associated with
accumulation of drugs in the body and they may experience drug toxicity
2
NR 565 Midterm Exam Questions And
Answers |Latest 2025 | Guaranteed Pass.
Which schedule drugs can APRNs prescribe? - Answer✔Varies state by state
May include schedule II-V, but never schedule I
Who determines and regulates prescriptive authority? - Answer✔The state's health
professional board
How does limited prescriptive authority impact patients within the healthcare system? -
Answer✔Creates numerous barriers to quality, affordable, and accessible patient care
May prevent outreach to areas of greatest need
Physician approval of prescriptions can increase patient waits
What are the key responsibilities of prescribing? - Answer✔A sound understanding of drugs and
the conditions that they are used to manage
Be deliberate in decision-making process
Do not prescribe for family or friends
Document thorough history and physical for the records, including education provided on drug
Have a documented plan for monitoring and titration
What should be used in making prescribing decisions? - Answer✔Cost, follow current
guidelines, availability, interactions, side effects, allergies, hepatic/renal function, need for
monitoring, special populations
PK and PD changes in older adults and how that affects how you prescribe? - Answer✔Very
high risk of adverse drug reactions and drug-drug interactions
D/t altered PK, multiple and severe illnesses, polypharmacy, poor adherence
Beer's Criteria - Answer✔List of potentially inappropriate medications to use in the older
populations
1
, ©THEBRIGHT 2024/2025 ALL RIGHTS RESERVED 10:15AM A+
Updated annually
Prescribers ultimately decide whether to prescribe or not
Impacts/outcomes of polypharmacy? - Answer✔Increased ADRs and drug-drug interactions
What are CYP450? - Answer✔Enzymes responsible for drug metabolism (biotransformation)-
oxidization, reduction, hydrolyzed to promote renal dug excretion
Hepatic enzyme system, composed of 12 enzyme families
What do CYP450 enzymes do? - Answer✔Promote drug excretion by making them more
"excretable"--hydrophilic/water soluble and charged (ion)
Inactivate drugs, increase therapeutic action through metabolism, activate a prodrug, decrease
drug toxicity
CYP450 inhibitor examples? - Answer✔VISA credit card debt inhibits spending on designers like
CK to look GQ
Valproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconzaole
Grapefruit juice
Quinidine
What do CYP450 inhibitors do? - Answer✔Decrease the rate of metabolism
Act on liver through process of inhibition
Slows rate of metabolism, increases active drug accumulation which can lead to adverse
reactions and drug toxicity
What do CYP450 inhibitors do if not used correctly? - Answer✔Can lead to adverse effects and
drug toxicity
What happens when someone has a poor metabolism phenotype? - Answer✔Associated with
accumulation of drugs in the body and they may experience drug toxicity
2
