NCLEX Practice Test for Endocrine
Disorders Part 2
1. Nurse Ronn is assessing a client with possible Cushing’s syndrome. In a client with Cushing’s
syndrome, the nurse would expect to find:
a. Hypotension.
b. Thick, coarse skin.
c. Deposits of adipose tissue in the trunk and dorsocervical area.
d. Weight gain in arms and legs.
2. A male client with primary diabetes insipidus is ready for discharge on desmopressin
(DDAVP). Which instruction should nurse Lina provide?
a. “Administer desmopressin while the suspension is cold.”
b. “Your condition isn’t chronic, so you won’t need to wear a medical identification bracelet.”
c. “You may not be able to use desmopressin nasally if you have nasal discharge or blockage.”
d. “You won’t need to monitor your fluid intake and output after you start taking desmopressin.”
3. Nurse Wayne is aware that a positive Chvostek’s sign indicate?
a. Hypocalcemia
b. Hyponatremia
c. Hypokalemia
d. Hypermagnesemia
4. In a 29-year-old female client who is being successfully treated for Cushing’s syndrome, nurse
Lyzette would expect a decline in:
a. Serum glucose level.
b. Hair loss.
c. Bone mineralization.
d. Menstrual flow.
5. A male client has recently undergone surgical removal of a pituitary tumor. Dr. Wong
prescribes corticotropin (Acthar), 20 units I.M. q.i.d. as a replacement therapy. What is the
mechanism of action of corticotropin?
a. It decreases cyclic adenosine monophosphate (cAMP) production and affects the metabolic
rate of target organs.
b. It interacts with plasma membrane receptors to inhibit enzymatic actions.
c. It interacts with plasma membrane receptors to produce enzymatic actions that affect protein,
fat, and carbohydrate metabolism.\
d. It regulates the threshold for water resorption in the kidneys.
6. Capillary glucose monitoring is being performed every 4 hours for a female client diagnosed
with diabetic ketoacidosis. Insulin is administered using a scale of regular insulin according to
glucose results. At 2 p.m., the client has a capillary glucose level of 250 mg/dl for which he
receives 8 U of regular insulin. Nurse Vince should expect the dose’s:
a. Onset to be at 2 p.m. and its peak to be at 3 p.m.
b. Onset to be at 2:15 p.m. and its peak to be at 3 p.m.
c. Onset to be at 2:30 p.m. and its peak to be at 4 p.m.
d. Onset to be at 4 p.m. and its peak to be at 6 p.m.
, 7. A female client with Cushing’s syndrome is admitted to the medical-surgical unit. During the
admission assessment, nurse Tyzz notes that the client is agitated and irritable, has poor memory,
reports loss of appetite, and appears disheveled. These findings are consistent with which
problem?
a. Depression
b. Neuropathy
c. Hypoglycemia
d. Hyperthyroidism
8. Nurse Ruth is assessing a client after a thyroidectomy. The assessment reveals muscle
twitching and tingling, along with numbness in the fingers, toes, and mouth area. The nurse
should suspect which complication?
a. Tetany
b. Hemorrhage
c. Thyroid storm
d. Laryngeal nerve damage
9. After undergoing a subtotal thyroidectomy, a female client develops hypothyroidism. Dr.
Smith prescribes levothyroxine (Levothroid), 25 mcg P.O. daily. For which condition is
levothyroxine the preferred agent?
a. Primary hypothyroidism
b. Graves’ disease
c. Thyrotoxicosis
d. Euthyroidism
10. Which of these signs suggests that a male client with the syndrome of inappropriate
antidiuretic hormone (SIADH) secretion is experiencing complications?
a. Tetanic contractions
b. Neck vein distention
c. Weight loss
d. Polyuria
11. A female client with a history of pheochromocytoma is admitted to the hospital in an acute
hypertensive crisis. To reverse hypertensive crisis caused by pheochromocytoma, nurse Lyka
expects to administer:
a. phentolamine (Regitine).
b. methyldopa (Aldomet).
c. mannitol (Osmitrol).
d. felodipine (Plendil).
12. A male client with a history of hypertension is diagnosed with primary hyperaldosteronism.
This diagnosis indicates that the client’s hypertension is caused by excessive hormone secretion
from which of the following glands?
a. Adrenal cortex
b. Pancreas
c. Adrenal medulla
d. Parathyroid
13. Nurse Troy is aware that the most appropriate for a client with Addison’s disease?
a. Risk for infection
b. Excessive fluid volume
c. Urinary retention
Disorders Part 2
1. Nurse Ronn is assessing a client with possible Cushing’s syndrome. In a client with Cushing’s
syndrome, the nurse would expect to find:
a. Hypotension.
b. Thick, coarse skin.
c. Deposits of adipose tissue in the trunk and dorsocervical area.
d. Weight gain in arms and legs.
2. A male client with primary diabetes insipidus is ready for discharge on desmopressin
(DDAVP). Which instruction should nurse Lina provide?
a. “Administer desmopressin while the suspension is cold.”
b. “Your condition isn’t chronic, so you won’t need to wear a medical identification bracelet.”
c. “You may not be able to use desmopressin nasally if you have nasal discharge or blockage.”
d. “You won’t need to monitor your fluid intake and output after you start taking desmopressin.”
3. Nurse Wayne is aware that a positive Chvostek’s sign indicate?
a. Hypocalcemia
b. Hyponatremia
c. Hypokalemia
d. Hypermagnesemia
4. In a 29-year-old female client who is being successfully treated for Cushing’s syndrome, nurse
Lyzette would expect a decline in:
a. Serum glucose level.
b. Hair loss.
c. Bone mineralization.
d. Menstrual flow.
5. A male client has recently undergone surgical removal of a pituitary tumor. Dr. Wong
prescribes corticotropin (Acthar), 20 units I.M. q.i.d. as a replacement therapy. What is the
mechanism of action of corticotropin?
a. It decreases cyclic adenosine monophosphate (cAMP) production and affects the metabolic
rate of target organs.
b. It interacts with plasma membrane receptors to inhibit enzymatic actions.
c. It interacts with plasma membrane receptors to produce enzymatic actions that affect protein,
fat, and carbohydrate metabolism.\
d. It regulates the threshold for water resorption in the kidneys.
6. Capillary glucose monitoring is being performed every 4 hours for a female client diagnosed
with diabetic ketoacidosis. Insulin is administered using a scale of regular insulin according to
glucose results. At 2 p.m., the client has a capillary glucose level of 250 mg/dl for which he
receives 8 U of regular insulin. Nurse Vince should expect the dose’s:
a. Onset to be at 2 p.m. and its peak to be at 3 p.m.
b. Onset to be at 2:15 p.m. and its peak to be at 3 p.m.
c. Onset to be at 2:30 p.m. and its peak to be at 4 p.m.
d. Onset to be at 4 p.m. and its peak to be at 6 p.m.
, 7. A female client with Cushing’s syndrome is admitted to the medical-surgical unit. During the
admission assessment, nurse Tyzz notes that the client is agitated and irritable, has poor memory,
reports loss of appetite, and appears disheveled. These findings are consistent with which
problem?
a. Depression
b. Neuropathy
c. Hypoglycemia
d. Hyperthyroidism
8. Nurse Ruth is assessing a client after a thyroidectomy. The assessment reveals muscle
twitching and tingling, along with numbness in the fingers, toes, and mouth area. The nurse
should suspect which complication?
a. Tetany
b. Hemorrhage
c. Thyroid storm
d. Laryngeal nerve damage
9. After undergoing a subtotal thyroidectomy, a female client develops hypothyroidism. Dr.
Smith prescribes levothyroxine (Levothroid), 25 mcg P.O. daily. For which condition is
levothyroxine the preferred agent?
a. Primary hypothyroidism
b. Graves’ disease
c. Thyrotoxicosis
d. Euthyroidism
10. Which of these signs suggests that a male client with the syndrome of inappropriate
antidiuretic hormone (SIADH) secretion is experiencing complications?
a. Tetanic contractions
b. Neck vein distention
c. Weight loss
d. Polyuria
11. A female client with a history of pheochromocytoma is admitted to the hospital in an acute
hypertensive crisis. To reverse hypertensive crisis caused by pheochromocytoma, nurse Lyka
expects to administer:
a. phentolamine (Regitine).
b. methyldopa (Aldomet).
c. mannitol (Osmitrol).
d. felodipine (Plendil).
12. A male client with a history of hypertension is diagnosed with primary hyperaldosteronism.
This diagnosis indicates that the client’s hypertension is caused by excessive hormone secretion
from which of the following glands?
a. Adrenal cortex
b. Pancreas
c. Adrenal medulla
d. Parathyroid
13. Nurse Troy is aware that the most appropriate for a client with Addison’s disease?
a. Risk for infection
b. Excessive fluid volume
c. Urinary retention
