NURS 8024 PHARM EXAM 3 (ANTIMICROBIAL
PART 2)
Voriconazole - ANSWERS-Causes immediate, transient visual disturbances
Systemic infections
Fluconazole - ANSWERS-Drug of choice in esophageal & oropharyngeal candidiasis
Single dose for vaginal candidiasis
Itraconazole - ANSWERS-Systemic infections
Posaconazole - ANSWERS-Broad spectrum
Serious systemic infection and prophylaxis cancer chemo
Echinocandins - ANSWERS-Newest class of antifungals
Caspofungin-first
Anidulafungin
Micafungin
Echinocandins MOA - ANSWERS-Interferes with the fungal cell wall synthesis
, Only IV dose
Echinocandins ADE - ANSWERS-GI Upset
Flushing, rash, elevated LFTs
Fever, HA, hypersensitivity
Griseofulvin - ANSWERS-Fungistatic
Systemic treatment of dermatophytosis of skin & hair
Given for 2-6 weeks and needs for replacement of infected keratin
Griseofulvin ADE - ANSWERS-HA, confusion
GI upset
Photosensitivity
Disulfiram like reactions with alcohol
Warfarin decreases bioavailability
Terbafine - ANSWERS-Interferes with ergosterol synthesis
Fungicidal
Daily for 12 weeks for onycomycosis
GI upset
Nystatin - ANSWERS-Topical use antifungal
PART 2)
Voriconazole - ANSWERS-Causes immediate, transient visual disturbances
Systemic infections
Fluconazole - ANSWERS-Drug of choice in esophageal & oropharyngeal candidiasis
Single dose for vaginal candidiasis
Itraconazole - ANSWERS-Systemic infections
Posaconazole - ANSWERS-Broad spectrum
Serious systemic infection and prophylaxis cancer chemo
Echinocandins - ANSWERS-Newest class of antifungals
Caspofungin-first
Anidulafungin
Micafungin
Echinocandins MOA - ANSWERS-Interferes with the fungal cell wall synthesis
, Only IV dose
Echinocandins ADE - ANSWERS-GI Upset
Flushing, rash, elevated LFTs
Fever, HA, hypersensitivity
Griseofulvin - ANSWERS-Fungistatic
Systemic treatment of dermatophytosis of skin & hair
Given for 2-6 weeks and needs for replacement of infected keratin
Griseofulvin ADE - ANSWERS-HA, confusion
GI upset
Photosensitivity
Disulfiram like reactions with alcohol
Warfarin decreases bioavailability
Terbafine - ANSWERS-Interferes with ergosterol synthesis
Fungicidal
Daily for 12 weeks for onycomycosis
GI upset
Nystatin - ANSWERS-Topical use antifungal
