NURS 8024 Pharm Exam 3 (antimicrobial
part 2)
Bacterial protein synthesis inhibitors - correct answer ✔✔Clindamycin
Clindamycin - correct answer ✔✔Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability
Clindamycin mechanism of resistance - correct answer ✔✔Altered target sites
Active efflux (pushes drug out of the cell)
Clindamycin ADE - correct answer ✔✔GI upset
Skin rash
Neutropenia
Superinfections such a c diff pseudomembranous
- don't use if patient has history of c diff
Clindamycin indications - correct answer ✔✔Gram positive
Prophylaxis of endocarditis in valve patients with PCN allergy
Oxazolidinones - correct answer ✔✔New class of bacterial protein synthesis inhibitors
Time dependent killing
Prevents formation of ribosome complex
Bacteriostatic & Bactericidal against strep
, Linezolid - correct answer ✔✔Protein synthesis inhibitor
100% bioavailability orally
30% CSF penetration
Linezolid ADE - correct answer ✔✔Hematologic
Increased thrombocytopenia risk
Anemia, neutropenia, neuropathy
Optic & peripheral neuropathy
Serotonin syndrome with SSRIs
Linezolid Indications - correct answer ✔✔Gram positive resistant
VRE, HCAP, CAP
Complicated skin & tissue infections
Off label use for TB
No resistance currently
Fluoroquinolones - correct answer ✔✔Norfloxacin (1st gen)
Ciprofloxacin & Ofloxacin (2nd gen)
Levofloxacin (3rd gen)
Moxifloxacin & Gemifloxacin (3rd gen respiratory)
Fluoroquinolones are classified by - correct answer ✔✔Generations according to antimicrobial spectra
1st Generation Fluoroquinolone - correct answer ✔✔Narrow gram negative
Norfloxacin
2nd Generation Fluoroquinolone - correct answer ✔✔Broad- gram negative and gram positive
Cipro & ofloxacin
part 2)
Bacterial protein synthesis inhibitors - correct answer ✔✔Clindamycin
Clindamycin - correct answer ✔✔Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability
Clindamycin mechanism of resistance - correct answer ✔✔Altered target sites
Active efflux (pushes drug out of the cell)
Clindamycin ADE - correct answer ✔✔GI upset
Skin rash
Neutropenia
Superinfections such a c diff pseudomembranous
- don't use if patient has history of c diff
Clindamycin indications - correct answer ✔✔Gram positive
Prophylaxis of endocarditis in valve patients with PCN allergy
Oxazolidinones - correct answer ✔✔New class of bacterial protein synthesis inhibitors
Time dependent killing
Prevents formation of ribosome complex
Bacteriostatic & Bactericidal against strep
, Linezolid - correct answer ✔✔Protein synthesis inhibitor
100% bioavailability orally
30% CSF penetration
Linezolid ADE - correct answer ✔✔Hematologic
Increased thrombocytopenia risk
Anemia, neutropenia, neuropathy
Optic & peripheral neuropathy
Serotonin syndrome with SSRIs
Linezolid Indications - correct answer ✔✔Gram positive resistant
VRE, HCAP, CAP
Complicated skin & tissue infections
Off label use for TB
No resistance currently
Fluoroquinolones - correct answer ✔✔Norfloxacin (1st gen)
Ciprofloxacin & Ofloxacin (2nd gen)
Levofloxacin (3rd gen)
Moxifloxacin & Gemifloxacin (3rd gen respiratory)
Fluoroquinolones are classified by - correct answer ✔✔Generations according to antimicrobial spectra
1st Generation Fluoroquinolone - correct answer ✔✔Narrow gram negative
Norfloxacin
2nd Generation Fluoroquinolone - correct answer ✔✔Broad- gram negative and gram positive
Cipro & ofloxacin
