CBC With Differential Challenge
Questions with Solutions 2024-2025
What are the 3 major stages of blood cell development? - Answer: Mesoblastic
Period (yolk sac phase)
Hepatic period
Medullary period (Bone marrow)
What is retrogression? - Answer: The process of replacing the active marrow with
adipose tissue during development into adulthood
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, CBC With Differential
What is extramedullary hematopoiesis and what is it associated with? - Answer:
When blood cells develop in the spleen and liver. It is associated with leukemia.
What cell has the characteristic marker of CD34 - Answer: Pluripotent
multiprogentaor stem cell
What are the 2 versions of "technology" used to run hematologic tests in a lab? -
Answer: Electrical impedance and optical scatter
How does the electrical impedance device work and what does it report? -
Answer: Passes blood cells through an electrode in a suspension and reports back
the total number of cells counted and the percentage of those cells are WBC's,
RBC's and platelets. However, it only gives a 3 part diff on WBC's separating out
lymphocytes, granulocytes, and then "everything else".
What should never be found in peripheral blood under normal conditions? -
Answer: Blast cells
How does the optical scatter device work and why is it better than the electrical
impedance device? - Answer: A laser is passed through the sample and the angle
of refraction gives a scatter plot as to the different types of cells. It is better
because it is more specific and accurate than the electrical impedance.
What are the different components of the CBC? - Answer: WBC
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