CMMB 413: MT 2 questions with correct answers rated A+ 2024/2025

CMMB 413: MT 2Underlying mechanism of abnormal chromosome segregation: - correct answer Nondisjunction Underlying mechanism of recurrent chromosome syndromes: - correct answer Recombination at segmental duplications Underlying mechanism of idiopathic chromosome abnormalities: - correct answer Sporadic, variable breakpoints Spontaneous/de novo. Sometimes of unknown origin. - correct answer Idiopathic Underlying mechanism of unbalanced familial abnormalities (heritable): - correct answer Unbalanced segregation More than three trisomic disorders may allow for post-natal survival, but only if they're ____. - correct answer Mosaic Three common phenotypes among different trisomies: ____ retardation, ____ retardation, ____ abnormalities. - correct answer Growth, mental, congenital Chromosomes ____ are the three most gene-poor. - correct answer 13, 18, 21 Three causes of trisomy 21: - correct answer Nondisjunction, Rob(14,;21), isochromosome 21q21q Patient's feet have a large gap between 1st and 2nd toe: typical of ____. - correct answer Down Syndrome 1/3 of infants with Down syndrome have: (lethal) - correct answer Congenital heart disease