FDA Exam 2 Questions & Answers 2023/2024

FDA Exam 2 Questions & Answers 2023/2024 What is the definition of pharmacodynamics? - ANSWER-what a drug molecule does to the body What is pharmacokinetics? - ANSWER-what the body does to the drug molecule What is the relationship between ionization and absorption? - ANSWER-Absorption or permeabilization favors small, uncharged agents. So when something is unionized, it will be more readily absorbed into the blood stream. However, when something is ionized, it will not be able to be absorbed as easily. What type of drugs are typically administered orally? - ANSWER-Drugs with the right balance between ionizable and hydrophobic FGs What is the difference between cis and trans orientations? - ANSWER-In cis, the bulky substituents on the same side of the plane of the double bond In trans, Bulky substituents on opposite sides of the plane What do E and Z mean in stereochemistry? - ANSWER-E is when the substituents of higher priority are on opposite sides of the plane of reference, and Z is when the substituents of higher priority are on the same side of the plane What four factors define the structure of a molecule? - ANSWER-composition, connectivity, configuration, and conformation What is the definition of an isomer? - ANSWER-molecules with the same composition but different connectivity What is the configuration of a molecule? - ANSWER-the spatial arrangement of its atoms, excluding those arrangements resulting from rotation around single bonds