Unit 4: Laboratory Techniques and their Application
Learning Aim C: Explore The Manufacturing Techniques And Testing
Methods For An Organic Solid
Aspirin:
Aspirin is an often prescribed medication for minor aches and pains as well as fevers. Some
individuals take it as an anti-inflammatory and a blood thinner. Aspirin is accessible without a
prescription over-the-counter. It can help with headaches, oedema, and body temperature. When used
on a regular basis, aspirin may help those who are at high risk of cardiovascular events including heart
attacks and strokes. Doctors can give aspirin to patients right after a heart attack to avoid blood clots
and heart tissue damage.
Preparation of aspirin:
Equipment:
Balance, Flask, Hot water bath, Ice bath, Condenser, Buchner funnel, Watch glass.
Reagents:
2-hydrobenzoiz acid, ethanoic anhydride, Concentrated phosphoric acid, water.
Method:
Take about 1 g of a sample of 2-hydrobenzoic acid and weigh it accurately. Hydroxybenzoic
acid can cause skin irritation. Wear gloves and a lab coat to prevent this. Place in a dry pear-shaped
flask, add 2 cc of acetic anhydride, followed by 8 drops of concentrated phosphoric acid. Concentrated
phosphoric acid can cause severe skin burns and eye damage. To prevent this, wear gloves, lab coat,
and protective goggles. Place the condenser in the flask. Spiralize the mixture in a boiling water bath in
the hood until all solids have dissolved, then heat for another 5 minutes. 5 mL cold water, carefully
added to the solution In an ice bath, place the flask until the precipitation appears to have ceased. To
start the precipitation process, vigorous stirring with a glass rod may be required. Using a Buchner
funnel and suction equipment, filter the product.
, http://www.chem.latech.edu/~deddy/chem104/104Aspirin.htm
Wash the item in cold water, then place it in a weighed watch glass to dry overnight. Calculate the
weight of your item.
Watch glass = 24.43g
Watch glass + Aspirin = 26.22g
Aspirin = 26.22 – 24.43 = 1.79g
After drying:
Watch glass + Aspirin = 25.53g
Aspirin = 25.53 - 24.43 = 1.1 g
Purifying by recrystallisation:
Learning Aim C: Explore The Manufacturing Techniques And Testing
Methods For An Organic Solid
Aspirin:
Aspirin is an often prescribed medication for minor aches and pains as well as fevers. Some
individuals take it as an anti-inflammatory and a blood thinner. Aspirin is accessible without a
prescription over-the-counter. It can help with headaches, oedema, and body temperature. When used
on a regular basis, aspirin may help those who are at high risk of cardiovascular events including heart
attacks and strokes. Doctors can give aspirin to patients right after a heart attack to avoid blood clots
and heart tissue damage.
Preparation of aspirin:
Equipment:
Balance, Flask, Hot water bath, Ice bath, Condenser, Buchner funnel, Watch glass.
Reagents:
2-hydrobenzoiz acid, ethanoic anhydride, Concentrated phosphoric acid, water.
Method:
Take about 1 g of a sample of 2-hydrobenzoic acid and weigh it accurately. Hydroxybenzoic
acid can cause skin irritation. Wear gloves and a lab coat to prevent this. Place in a dry pear-shaped
flask, add 2 cc of acetic anhydride, followed by 8 drops of concentrated phosphoric acid. Concentrated
phosphoric acid can cause severe skin burns and eye damage. To prevent this, wear gloves, lab coat,
and protective goggles. Place the condenser in the flask. Spiralize the mixture in a boiling water bath in
the hood until all solids have dissolved, then heat for another 5 minutes. 5 mL cold water, carefully
added to the solution In an ice bath, place the flask until the precipitation appears to have ceased. To
start the precipitation process, vigorous stirring with a glass rod may be required. Using a Buchner
funnel and suction equipment, filter the product.
, http://www.chem.latech.edu/~deddy/chem104/104Aspirin.htm
Wash the item in cold water, then place it in a weighed watch glass to dry overnight. Calculate the
weight of your item.
Watch glass = 24.43g
Watch glass + Aspirin = 26.22g
Aspirin = 26.22 – 24.43 = 1.79g
After drying:
Watch glass + Aspirin = 25.53g
Aspirin = 25.53 - 24.43 = 1.1 g
Purifying by recrystallisation:
