IMM250 CHAPTER 1-5 TOPHAT
CHAPTER ONE
1. Edward Jenner’s experiment was based on his observation that dairy workers seemed immune
to smallpox. He performed a famous experiment on an eight-year-old boy named James
Phipps. Which of the following best describes the crucial and innovative step of Jenner's
experiment and its rationale?
A: Jenner, before subjecting James to variolation, inoculated him with cowpox. Jenner thought that
persons infected with cowpox developed a form of immunity that protected them from smallpox
2. The first cholera vaccine created by Louis Pasteur is comparable to Jenner’s cowpox vaccine
because both vaccines induced immunity as a consequence of:
A: Using a less virulent form of the pathogen for inoculation
3. Emil von Behring and Shibasaburo Kitasato transferred cell-free serum from animals
immunized with diphtheria into guinea pigs that had never been exposed to diphtheria. They
were able to demonstrate:
A: All of the above
4. Many aspects of the side-chain theory of antibody formation proposed by Paul Ehrlich have
been proved correct with the exception of?
A: The idea that a single cell can express many different membrane-bound anti-toxins for different
antigens
5. Indicate in the list below the one feature that does not characterize adaptive immunity.
A: Rapid response (minutes, hours)
6. Which of the following are cells that first detect the presence of pathogens in tissues?
A: Macrophages, Dendritic cells
CHAPTER TWO
7. Koch’s postulates are:
A: Rules to be used to determine the causative agent of infectious diseases
8. Identify the incorrect statement about H. pylori infection.
A: *H. pylori* is never part of the normal microbiota
9. Ebola and SARS are examples of:
A: Emerging infections
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, 10. The bacterial structure attacked by defensins is:
A: Plasma membrane
11. Select the structures classified as PAMPs in the following list:
A: Endotoxin, Viral RNA, Peptidoglyca
12. Select all that apply. Binding of soluble LPS to TLR-4 requires the participation of:
A: CD14, MD-2, LBP
13. Which of the following statements concerned with PRRs is NOT true:
A: They are only expressed in leukocytes, such as macrophages or neutrophilS
CHAPTER THREE
14. Which of the following statements about macrophages is false?
A: They are found in blood
15. Indicate which of the following properties does not apply to neutrophils
A: They are tissue-resident cells
16. In neutrophils, ingested microbes are found in phagosomes and are killed by
A: All of the above
17. Type the name of the cell that releases granules containing cationic proteins toxic to parasites
A: Eosinophil
18. Which of the following changes is NOT seen at infected sites as a consequence of an acute
inflammatory response:
A: Vasoconstriction
19. During leukocyte extravasation, the role of integrins is:
A: To mediate the tight binding of leukocytes to the endothelial cells. To bind to ICAMs expressed on
endothelial cells
20. Which of the following features does not describe CRP?
A: A member of the Collectin family
21. An enzyme that can cleave C3 is
A: C3bBb
This study source was downloaded by 100000858936669 from CourseHero.com on 01-18-2023 07:46:14 GMT -06:00
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CHAPTER ONE
1. Edward Jenner’s experiment was based on his observation that dairy workers seemed immune
to smallpox. He performed a famous experiment on an eight-year-old boy named James
Phipps. Which of the following best describes the crucial and innovative step of Jenner's
experiment and its rationale?
A: Jenner, before subjecting James to variolation, inoculated him with cowpox. Jenner thought that
persons infected with cowpox developed a form of immunity that protected them from smallpox
2. The first cholera vaccine created by Louis Pasteur is comparable to Jenner’s cowpox vaccine
because both vaccines induced immunity as a consequence of:
A: Using a less virulent form of the pathogen for inoculation
3. Emil von Behring and Shibasaburo Kitasato transferred cell-free serum from animals
immunized with diphtheria into guinea pigs that had never been exposed to diphtheria. They
were able to demonstrate:
A: All of the above
4. Many aspects of the side-chain theory of antibody formation proposed by Paul Ehrlich have
been proved correct with the exception of?
A: The idea that a single cell can express many different membrane-bound anti-toxins for different
antigens
5. Indicate in the list below the one feature that does not characterize adaptive immunity.
A: Rapid response (minutes, hours)
6. Which of the following are cells that first detect the presence of pathogens in tissues?
A: Macrophages, Dendritic cells
CHAPTER TWO
7. Koch’s postulates are:
A: Rules to be used to determine the causative agent of infectious diseases
8. Identify the incorrect statement about H. pylori infection.
A: *H. pylori* is never part of the normal microbiota
9. Ebola and SARS are examples of:
A: Emerging infections
This study source was downloaded by 100000858936669 from CourseHero.com on 01-18-2023 07:46:14 GMT -06:00
https://www.coursehero.com/file/79355052/IMM250-TOPHATdocx/
, 10. The bacterial structure attacked by defensins is:
A: Plasma membrane
11. Select the structures classified as PAMPs in the following list:
A: Endotoxin, Viral RNA, Peptidoglyca
12. Select all that apply. Binding of soluble LPS to TLR-4 requires the participation of:
A: CD14, MD-2, LBP
13. Which of the following statements concerned with PRRs is NOT true:
A: They are only expressed in leukocytes, such as macrophages or neutrophilS
CHAPTER THREE
14. Which of the following statements about macrophages is false?
A: They are found in blood
15. Indicate which of the following properties does not apply to neutrophils
A: They are tissue-resident cells
16. In neutrophils, ingested microbes are found in phagosomes and are killed by
A: All of the above
17. Type the name of the cell that releases granules containing cationic proteins toxic to parasites
A: Eosinophil
18. Which of the following changes is NOT seen at infected sites as a consequence of an acute
inflammatory response:
A: Vasoconstriction
19. During leukocyte extravasation, the role of integrins is:
A: To mediate the tight binding of leukocytes to the endothelial cells. To bind to ICAMs expressed on
endothelial cells
20. Which of the following features does not describe CRP?
A: A member of the Collectin family
21. An enzyme that can cleave C3 is
A: C3bBb
This study source was downloaded by 100000858936669 from CourseHero.com on 01-18-2023 07:46:14 GMT -06:00
https://www.coursehero.com/file/79355052/IMM250-TOPHATdocx/
