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UNIT 6 AS BIOLOGY

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What are the steps in DNA packaging?
What are the steps in DNA packaging?
DNA double helix: the length of the DNA molecule in an average human chromosome is about 4.8cm long-------------------------------------------------------- Nucleosome fibre: the DNA is wrapped around histone proteins, forming chromatin. Histones associate in octamers to form “beads-on-a-string” structures called nucleosomes. These are the basic unit of chromosomes------- Solenoide fibre: more histones help the nucleosome fibre form a tightly-coiled structure called a solenoid fibre-------------------------------------------------- Folded/coiled solenoid fibre: the solenoid fibre is thought to wrap and coil around scaffolding proteins, but the exact mechanism of this is not known----- Supercoiling: to reduce the stress on the molecule, the solenoid fibre twists and writhes, like a curly telephone cable. The sum of this twisting and writhing is supercoiling-------------------------------------------------------------------- Chromosome: the DNA molecule is packed so much that the average human chromosome is just 6μm long. Here, the chromosome has replicated so it contains two DNA molecules
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