NR283 Pathophysiology Exam 3 Review Chapter 19 Alterations of Hormonal Regulation - Addison’s disease – (Adrenal Insufficiency)- - - Autoimmune disorder where body creates antigens that attack the adrenal glands - - decrease in hormones in adrenal cortex such as corticosteroid and mineralocorticoid synthesis and elevated levels of ACTH (loss of negative feedback). - -More then 90% of adrenocortical tissue is destroyed causing clinical manifestations. - - No adrenal glands working resulting i...