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Hormone cycles of menstruation - correct answer -Gonadotropin
releasing hormone from hypothalamus -->
Stimulates anterior pituitary secretion of FSH and LH -->
a dominant ovarian follicle emerges by day 5-7 of menstrual cycle -->
rising estradiol levels -->
proliferation of endometrium
Estradiol mediated negative feedback --> dec FSH
Estradiol mediated positive feedback --> Inc LH
Rising LH --> progesterone secretion -->
further stimulates LH and FSH -->
follicle ruptures and oocyte is expelled -->
dec LH and FSH
Inc estrogen and progesterone -->
if pregnancy and placental hCG release do not occur -->
,dec estrogen and progesterone, and endometrium sheds
Normal first 2 years of menarche - correct answer -majority of cycles
are anovulatory
10-20% of cycles are anovulatory for up to 5 years after menarchy
Amenorrhea - correct answer -Primary amenorrhea- no periods or
secondary sex characteristics by age 13 or no menses in the presence of
secondary sex characteristics by age 15.
Secondary amenorrhea- the absence of menses for three consecutive
cycles or for 6 months in a patient with irregular cycles
DDx of amenorrhea from hypothalamic-pituitary axis - correct answer -
Hypothalamic suppression
-chronic dz
-stress
-malnutrition
,-strenuous athletics
-drugs (haldol, phenothiazines, atypical antipsychotics)
CNS lesion
-pituitary lesion- adenoma, prolactinoma
-craniopharyngioma, brainstem, or parasellar tumors
-Head injury with hypothalamic contusion
-Infiltrative process (sarcoidosis)
-Vascular disease- hypothalamic vasculitis
Congenital conditions
-Kallmann syndrome (anosmia)
DDx of amenorrhea by ovaries - correct answer -Gonadal dysgenesis
-turner syndrome
-mosaic
Injury to ovary
-autoimmune disease (oophoritis)
-Infection (mumps)
, -Toxins (alkylating chemotherapeutic agent)
-Irradiation
-Trauma, torsion
PCOS
Ovarian failure
DDx of ameorrhea by uterovaginal outflow tract - correct answer -
Mullerian dysgenesis
-congenital deformity or absence of uterus, uterine tubes, or vagina
Imperforate hymen, transverse vaginal septum, vaginal agenesis,
agenesis of the cervix
Androgen insensitivity syndrome
Uterine lining defect
-asherman syndrome
-TB, brucellis
DDx of amenorrhea by defect in hormone synthesis or action - correct
answer -Adrenal hyperplasia
Cushing Disease