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A 32-year old female is seen at your office complaining of
a recent onset of blurred vision, only at a distance. A
thorough case history reveals that she recently began
taking a new medication which you correctly assume has
induced myopia. Which of the following medications is
MOST likely to be the culprit? - ANSWER-Isotretinoin, birth
control pills, and diuretics, among many other drugs, can
cause myopia in some patients. Myopia mostly likely
results from corneal swelling, which steepens the
curvature of the cornea. Drugs that cause swelling of the
,lens, accommodative spasm, or edema of the ciliary body
will also result in myopia. A reduction in the dose of the
medication or cessation of the offending drug will usually
result in reversal of nearsightedness. Fish oil, Tylenol, and
Tums have not been shown to have a correlation with
transient myopia development.
An increased rate of molecular movement down its
respective concentration gradient via help from carrier
proteins refers to which type of transportation? -
ANSWER-Facilitated diffusion is described as the net
movement of molecules down its concentration gradient
whose rate of diffusion is increased via the use of carrier
proteins. Passive diffusion refers to the movement of
molecules through a plasma membrane from an area of
,high concentration to an area of low concentration without
the use of carrier molecules. Active transport implies the
movement of material against its respective concentration
gradient. This type of transport requires energy and enlists
the use of specific carrier proteins. Lastly, group
translocation is defined as the chemical modification of a
molecule while it is being transported into a cell; for
example, sugars are often phosphorylated during
transportation.
A 24-year old female patient presents at your office
complaining of side effects that began when she started
using Patanol to treat her ocular allergies. She reports
complete compliance with her eye drop administration.
Which of the following symptoms is MOST likely
, associated with olopatadine (Patanol) use? - ANSWER-
Topical antihistamines and mast cell stabilizers such as
Patanol (olopatadine) are commonly prescribed to relieve
the symptoms associated with ocular allergies. They are a
very effective class of medication due to their dual action
mechanisms. Topical antihistamines that possess this dual
action are olopatadine (Patanol), ketotifen fumarate
(Zaditor), azelastine (Optivar), and epinastine (Elestat).
The aforementioned drops serve to alleviate itching and
redness by blocking H1 receptors as well as inhibiting
mast cell and basophil degranulation. Side effects of
topical antihistamine/mast cell stabilizers include stinging
upon instillation, headaches, and adverse taste (don't
forget to inform your patients about punctual occlusion!).
Tachycardia, depression, gastrointestinal discomfort, and