Mastery Guide
For Penn Foster Students – 100 Structured Q&A with Verified
Answers
Section 1: Fundamental Principles (Questions 1-20)
1. What is the primary definition of pharmacology?
• A) The study of drug manufacturing
• B) The study of drugs and their interactions with living systems
• C) The study of animal diseases
• D) The study of surgical techniques
2. Which branch of pharmacology deals with the biochemical and physiological effects of
drugs?
• A) Pharmacokinetics
• B) Pharmacodynamics
• C) Pharmacy
• D) Toxicology
3. The term describing a drug's movement through the body (ADME) is:
• A) Pharmacotherapeutics
• B) Pharmacokinetics
• C) Pharmacodynamics
• D) Pharmacognosy
4. Which route of administration bypasses first-pass metabolism?
• A) Oral
• B) Rectal
, • C) Intravenous
• D) All of the above
5. The time required for drug concentration to decrease by 50% is called:
• A) Onset time
• B) Duration of action
• C) Half-life
• D) Therapeutic index
6. What does a low therapeutic index indicate about a drug?
• A) It is very safe
• B) It has a wide margin of safety
• C) It has a narrow margin of safety
• D) It is always effective
7. Which phase of clinical trials involves initial testing in a small group of healthy animals?
• A) Phase I
• B) Phase II
• C) Phase III
• D) Phase IV
8. The study of adverse drug effects is called:
• A) Pharmacodynamics
• B) Toxicology
• C) Pharmacogenetics
• D) Pharmacy
9. Which law regulates the manufacturing and distribution of controlled substances in
veterinary medicine?
• A) Animal Medicinal Drug Use Clarification Act (AMDUCA)
• B) Controlled Substances Act (CSA)
, • C) Food, Drug, and Cosmetic Act
• D) Veterinary Feed Directive
10. What does the abbreviation "EMEA" stand for in drug regulation?
• A) European Medicines Agency
• B) Emergency Medical Assistance
• C) Extended Medication Efficacy Analysis
• D) Equine Medication Examination Authority
11. Drugs that bind to receptors and produce a response are called:
• A) Antagonists
• B) Agonists
• C) Partial agonists
• D) Inverse agonists
12. What type of drug antagonism occurs when two drugs compete for the same receptor
site?
• A) Physiological antagonism
• B) Chemical antagonism
• C) Competitive antagonism
• D) Non-competitive antagonism
13. Which of these factors does NOT affect drug absorption?
• A) Blood flow to absorption site
• B) Drug solubility
• C) Patient's age
• D) Drug color
14. The process by which drugs are transported from systemic circulation to tissues is:
• A) Absorption
• B) Distribution
, • C) Metabolism
• D) Excretion
15. Which organ is primarily responsible for drug metabolism?
• A) Kidney
• B) Liver
• C) Lung
• D) Spleen
16. The primary route of excretion for most drugs is through the:
• A) Kidneys
• B) Liver
• C) Lungs
• D) Sweat glands
17. Drugs that cross the blood-brain barrier most easily are typically:
• A) Highly protein-bound
• B) Highly ionized
• C) Lipid-soluble
• D) Water-soluble
18. Which is an example of a prodrug?
• A) Prednisone converted to prednisolone
• B) Penicillin G
• C) Furosemide
• D) Diazepam
19. What does "bioavailability" refer to?
• A) The chemical purity of a drug
• B) The percentage of drug that reaches systemic circulation
• C) The expiration date of a medication