THIS DOCUMET BELONGS TO TESTBANKSPROF
Test Bank Cellular and Molecular Immunology10th Edition
By Abul Abbas, Andrew Lichtman, and Shiv Pillai
All Chapters (1-21) Q&A Verified With Rationales| Grade A+
Assured
ISBN 9780323757485
~1~
,THIS DOCUMET BELONGS TO TESTBANKSPROF
TABLE OF CONTENTS
Chapter 01: Properties and Overview of Immune Responses............................... 3
Chapter 02: Cells and Tissues of the Immune System ........................................ 5
Chapter 03: Leukocyte Circulation and Migration Into Tissues ........................ 8
Chapter 04: Innate Immunity ........................................................................... 12
Chapter 05: Antibodies and Antigens ............................................................... 20
Chapter 06: Antigen Presentation to T Lymphocytes and thedFunctions of
Major Histocom patibility Complex Molecules ................................................ 22
Chapter 07: Immune Receptors and Signal Transduction ............................... 29
Chapter 08: Lymphocyte Development and Antigen Receptor Gene
Rearrangement ................................................................................................. 32
Chapter 09: Activation of T Lymphocytes ......................................................... 37
Chapter 10: Differentiation and Functions of CD4+ Effector T Cells ............... 41
Chapter 11: Differentiation and Functions of CD8+ Effector T Cells ............... 45
Chapter 12: B CelldActivation and Antibody Production ................................. 49
Chapter 13: Effector Mechanisms of Humoral Immunity ................................ 56
Chapter 14: Specialized Immunity at Epithelial Barriers and in Immune
Privileged .......................................................................................................... 60
Chapter 15: Immunologic Tolerance and Autoimmunity ................................ 68
Chapter 16: Immunity to Microbes................................................................... 73
Chapter 17: Transplantation Immunology .......................................................... 78
Chapter 18: Tumor Immunology ...................................................................... 84
Chapter 19: Hypersensitivity Disorders........................................................... 88
Chapter 20: Allergy ........................................................................................... 94
Chapter 21: Primary and Acquired Immunodeficiencies ................................ 98
~2~
, THIS DOCUMET BELONGS TO TESTBANKSPROF
Chapter 01: Properties and Overview of Immune Responses
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
MULTIPLE CHOICE
1. The principal function of the immune system is:
a. Defense against cancer
b. Repair of injured tissues
c. Defense against microbial infections
d. Prevention of inflammatory diseases
e. Protection against environmental toxins
CORRECT ANSWER: C
The immune system has evolved in the setting of selective pressures imposed by
microbial infections. Although immune responses to cancer may occur, the concept that
“immunosurveillance” against cancer is a principal function of the immune system is
controversial. Repair of injured tissues may be a secondary consequence of the immune
responses and inflammation. Although the immune system has regulatory features that
are needed to prevent excessive inflammation, prevention of inflammatory diseases is
not a primary function. The immune system can protect against microbial toxins, but it
generally does not offer protection against toxins of nonbiologic origin.
2. Which of the following infectious diseases was prevented by the first successful
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
CORRECT ANSWER: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In
1980, smallpox was reported to be eradicated worldwide by a vaccination program.
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed in
the 20th century and are widely used. There is no effective vaccine against
Mycobacterium tuberculosis.
3. Which of the following is a unique property of the adaptive immune system?
a. Highly diverse repertoire of specificities for antigens
~3~
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b. Self-nonself discrimination
c. Recognition of microbial structures by both cell-associated and soluble receptors
d. Protection against viral infections
e. Responses that have the same kinetics and magnitude on repeated exposure to
the same microbe
CORRECT ANSWER: A
Highly diverse repertoires of specificities for antigens are found only in T and B
lymphocytes, which are the central cellular components of the adaptive immune system.
Both the innate and the adaptive immune systems use cell-associated and soluble
receptors to recognize microbes, display some degree of self-nonself discrimination, and
protect against viruses. On repeated exposure to the same microbe, the adaptive
immune response becomes more rapid and of greater magnitude; this is the
manifestation of memory.
4. Antibodies and T lymphocytes are the respective mediators of which two types of
immunity?
a. Innate and adaptive
b. Passive and active
c. Specific and nonspecific
d. Humoral and cell-mediated
e. Adult and neonatal
CORRECT ANSWER: D
Both B and T lymphocytes are principal components of adaptive immunity. B
lymphocytes produce antibodies, which are the recognition and effector molecules of
humoral immune responses to extracellular pathogens. T cells recognize and promote
eradication of intracellular pathogens in cell-mediated immunity. Passive and active
immunity both can be mediated by either B or T lymphocytes. Specific immunity is
another term for adaptive immunity. Both B and T lymphocytes participate in adult
adaptive immunity but are still developing in the neonatal period.
5. The two major functional classes of effector T lymphocytes are:
a. Helper T lymphocytes and cytotoxic T lymphocytes
b. Natural killer cells and cytoWtoWxWic.TTlBySmMph.oWcyStes
c. Memory T cells and effector T cells
d. Helper cells and antigen-presenting cells
e. Cytotoxic T lymphocytes and target cells
CORRECT ANSWER: A
~4~
Test Bank Cellular and Molecular Immunology10th Edition
By Abul Abbas, Andrew Lichtman, and Shiv Pillai
All Chapters (1-21) Q&A Verified With Rationales| Grade A+
Assured
ISBN 9780323757485
~1~
,THIS DOCUMET BELONGS TO TESTBANKSPROF
TABLE OF CONTENTS
Chapter 01: Properties and Overview of Immune Responses............................... 3
Chapter 02: Cells and Tissues of the Immune System ........................................ 5
Chapter 03: Leukocyte Circulation and Migration Into Tissues ........................ 8
Chapter 04: Innate Immunity ........................................................................... 12
Chapter 05: Antibodies and Antigens ............................................................... 20
Chapter 06: Antigen Presentation to T Lymphocytes and thedFunctions of
Major Histocom patibility Complex Molecules ................................................ 22
Chapter 07: Immune Receptors and Signal Transduction ............................... 29
Chapter 08: Lymphocyte Development and Antigen Receptor Gene
Rearrangement ................................................................................................. 32
Chapter 09: Activation of T Lymphocytes ......................................................... 37
Chapter 10: Differentiation and Functions of CD4+ Effector T Cells ............... 41
Chapter 11: Differentiation and Functions of CD8+ Effector T Cells ............... 45
Chapter 12: B CelldActivation and Antibody Production ................................. 49
Chapter 13: Effector Mechanisms of Humoral Immunity ................................ 56
Chapter 14: Specialized Immunity at Epithelial Barriers and in Immune
Privileged .......................................................................................................... 60
Chapter 15: Immunologic Tolerance and Autoimmunity ................................ 68
Chapter 16: Immunity to Microbes................................................................... 73
Chapter 17: Transplantation Immunology .......................................................... 78
Chapter 18: Tumor Immunology ...................................................................... 84
Chapter 19: Hypersensitivity Disorders........................................................... 88
Chapter 20: Allergy ........................................................................................... 94
Chapter 21: Primary and Acquired Immunodeficiencies ................................ 98
~2~
, THIS DOCUMET BELONGS TO TESTBANKSPROF
Chapter 01: Properties and Overview of Immune Responses
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
MULTIPLE CHOICE
1. The principal function of the immune system is:
a. Defense against cancer
b. Repair of injured tissues
c. Defense against microbial infections
d. Prevention of inflammatory diseases
e. Protection against environmental toxins
CORRECT ANSWER: C
The immune system has evolved in the setting of selective pressures imposed by
microbial infections. Although immune responses to cancer may occur, the concept that
“immunosurveillance” against cancer is a principal function of the immune system is
controversial. Repair of injured tissues may be a secondary consequence of the immune
responses and inflammation. Although the immune system has regulatory features that
are needed to prevent excessive inflammation, prevention of inflammatory diseases is
not a primary function. The immune system can protect against microbial toxins, but it
generally does not offer protection against toxins of nonbiologic origin.
2. Which of the following infectious diseases was prevented by the first successful
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
CORRECT ANSWER: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In
1980, smallpox was reported to be eradicated worldwide by a vaccination program.
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed in
the 20th century and are widely used. There is no effective vaccine against
Mycobacterium tuberculosis.
3. Which of the following is a unique property of the adaptive immune system?
a. Highly diverse repertoire of specificities for antigens
~3~
, THIS DOCUMET BELONGS TO TESTBANKSPROF
b. Self-nonself discrimination
c. Recognition of microbial structures by both cell-associated and soluble receptors
d. Protection against viral infections
e. Responses that have the same kinetics and magnitude on repeated exposure to
the same microbe
CORRECT ANSWER: A
Highly diverse repertoires of specificities for antigens are found only in T and B
lymphocytes, which are the central cellular components of the adaptive immune system.
Both the innate and the adaptive immune systems use cell-associated and soluble
receptors to recognize microbes, display some degree of self-nonself discrimination, and
protect against viruses. On repeated exposure to the same microbe, the adaptive
immune response becomes more rapid and of greater magnitude; this is the
manifestation of memory.
4. Antibodies and T lymphocytes are the respective mediators of which two types of
immunity?
a. Innate and adaptive
b. Passive and active
c. Specific and nonspecific
d. Humoral and cell-mediated
e. Adult and neonatal
CORRECT ANSWER: D
Both B and T lymphocytes are principal components of adaptive immunity. B
lymphocytes produce antibodies, which are the recognition and effector molecules of
humoral immune responses to extracellular pathogens. T cells recognize and promote
eradication of intracellular pathogens in cell-mediated immunity. Passive and active
immunity both can be mediated by either B or T lymphocytes. Specific immunity is
another term for adaptive immunity. Both B and T lymphocytes participate in adult
adaptive immunity but are still developing in the neonatal period.
5. The two major functional classes of effector T lymphocytes are:
a. Helper T lymphocytes and cytotoxic T lymphocytes
b. Natural killer cells and cytoWtoWxWic.TTlBySmMph.oWcyStes
c. Memory T cells and effector T cells
d. Helper cells and antigen-presenting cells
e. Cytotoxic T lymphocytes and target cells
CORRECT ANSWER: A
~4~
