NR566 / NR 566 Final Exam Review Advanced Pharmacology
for Care of the Family
Expected Questions and Verified Answers
1. Raloxifene (Evista) and bisphosphonates (alendronate, calcitonin)
Ans>> alterna-
tives for hormone replacement therapy
2. Selective Estrogen Receptor Modulators (SERMs)
Ans>> Tamoxifen, toremifene, raloxifene -- provide estrogen benefits while avoiding its
drawbacks
3. Dysfunctional uterine bleeding
Ans>> 10-14 day course of progestin
1/
5
,4. Amenorrhea treatment
Ans>> progestin helps induce menstrual flow
5. Amenorrhea estrogen levels are low
Ans>> give progestin for 5-10 days
6. Long term progestin therapy
Ans>> protection against endometrial cancer
7. Estradiol
Ans>> most active estrogenic compound. oral estrogen option
8. Advantages of estrogen transdermal patch
Ans>> lower total estrogen dose. less n/v. less fluctuation of estrogen blood levels. lower
r/f DVT, PE and stroke
9. Femring
Ans>> intravaginal ring controls hot flashes and night sweats.Treats vulval and vaginal atroph
2/
5
, 10.No gap method of changing from one OC to another
Ans>> go straight from one type of OC to the other without taking a gap.
11.initiating OC treatment
Ans>> first day of menstrual cycle (no backup BC needed) OR first sunday after onset of
menses (backup BC needed for 7 days)
12.Initiating androgen therapy short term
Ans>> delayed sexual maturation causing a boy significant distress. Limited course of
Fluoxymesterone and methyltestosterone are approved.
13.androgen therapy long term
Ans>> if delayed puberty is the result of true hypogo- nadism
3/
5
for Care of the Family
Expected Questions and Verified Answers
1. Raloxifene (Evista) and bisphosphonates (alendronate, calcitonin)
Ans>> alterna-
tives for hormone replacement therapy
2. Selective Estrogen Receptor Modulators (SERMs)
Ans>> Tamoxifen, toremifene, raloxifene -- provide estrogen benefits while avoiding its
drawbacks
3. Dysfunctional uterine bleeding
Ans>> 10-14 day course of progestin
1/
5
,4. Amenorrhea treatment
Ans>> progestin helps induce menstrual flow
5. Amenorrhea estrogen levels are low
Ans>> give progestin for 5-10 days
6. Long term progestin therapy
Ans>> protection against endometrial cancer
7. Estradiol
Ans>> most active estrogenic compound. oral estrogen option
8. Advantages of estrogen transdermal patch
Ans>> lower total estrogen dose. less n/v. less fluctuation of estrogen blood levels. lower
r/f DVT, PE and stroke
9. Femring
Ans>> intravaginal ring controls hot flashes and night sweats.Treats vulval and vaginal atroph
2/
5
, 10.No gap method of changing from one OC to another
Ans>> go straight from one type of OC to the other without taking a gap.
11.initiating OC treatment
Ans>> first day of menstrual cycle (no backup BC needed) OR first sunday after onset of
menses (backup BC needed for 7 days)
12.Initiating androgen therapy short term
Ans>> delayed sexual maturation causing a boy significant distress. Limited course of
Fluoxymesterone and methyltestosterone are approved.
13.androgen therapy long term
Ans>> if delayed puberty is the result of true hypogo- nadism
3/
5
