NR566 / NR 566 Final Exam Review Advanced Pharmacolog
for Care of the Family Expected Questions and Verified Answers
1. Mechanism of action of estrogen and
progestin Ans>> Diffuses into cells to bind to
their receptors in the cell nucleus. A hormone-receptor complex is formed, which then binds
to the target gene to alter the rate of gene transcription
2. Estrogen and progestin
baseline Ans>> HR BP
Weight Pregnancy
test
Screen for breast cancer
Screen for cardiovascular
disease (estrogen-only) - TSH,
triglycerides
3. Estrogen/progestin contraindications
Ans>> Abnormal vaginal bleeding Estrogen-dependent cancers
1/
18
,Breast cancer
Hx thrombus (DVT, PE, MI, CVA) - estrogen only Abnormal
liver function
4. Estrogen adverse
effects Ans>> -
Nausea
- Breast tenderness
- Bloating/Weight gain
- Increased BP
- Thrombosis
5. Why should estrogen be taken with progestin in
menopausal women? Ans>> If they take estrogen alone, there is an
increased risk of endometrial cancer
6. Role of progesterone in menstrual cycle
Ans>> Secreted in 2nd half of menstrual cycle. If there is no pregnancy, the levels will
decrease
7. Role of progesterone in pregnancy
Ans>> Helps maintain pregnancy by preventing uterine contraction
Decreases GI muscle contraction (causes constipation)
Promotes breast milk production
Increases pH and suppresses pCO2
2/
18
,Suppresses maternal immune system (prevents attack on fetus)
3/
18
, 8. Therapeutic use of progestin
Ans>> Counteracts endometrial hyperplasia caused by estrogen alone
Manages dysfunctional uterine bleeding, amenorrhea and
endometriosis
4/
18
for Care of the Family Expected Questions and Verified Answers
1. Mechanism of action of estrogen and
progestin Ans>> Diffuses into cells to bind to
their receptors in the cell nucleus. A hormone-receptor complex is formed, which then binds
to the target gene to alter the rate of gene transcription
2. Estrogen and progestin
baseline Ans>> HR BP
Weight Pregnancy
test
Screen for breast cancer
Screen for cardiovascular
disease (estrogen-only) - TSH,
triglycerides
3. Estrogen/progestin contraindications
Ans>> Abnormal vaginal bleeding Estrogen-dependent cancers
1/
18
,Breast cancer
Hx thrombus (DVT, PE, MI, CVA) - estrogen only Abnormal
liver function
4. Estrogen adverse
effects Ans>> -
Nausea
- Breast tenderness
- Bloating/Weight gain
- Increased BP
- Thrombosis
5. Why should estrogen be taken with progestin in
menopausal women? Ans>> If they take estrogen alone, there is an
increased risk of endometrial cancer
6. Role of progesterone in menstrual cycle
Ans>> Secreted in 2nd half of menstrual cycle. If there is no pregnancy, the levels will
decrease
7. Role of progesterone in pregnancy
Ans>> Helps maintain pregnancy by preventing uterine contraction
Decreases GI muscle contraction (causes constipation)
Promotes breast milk production
Increases pH and suppresses pCO2
2/
18
,Suppresses maternal immune system (prevents attack on fetus)
3/
18
, 8. Therapeutic use of progestin
Ans>> Counteracts endometrial hyperplasia caused by estrogen alone
Manages dysfunctional uterine bleeding, amenorrhea and
endometriosis
4/
18
