TEST BANK pc
Cellular and Molecular Immunology
pc pc pc
Abul Abbas, Andrew Lichtman, and Shiv Pillai
pc pc pc pc pc pc
10th Edition
pc
,Table of Contents
pc pc
Chapter 01 Properties and Overview of Immune Responses
pc pc pc pc pc pc pc 1
Chapter 02 Cells and Tissues of the Immune System
pc pc pc pc pc pc pc pc 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
pc pc pc pc pc pc pc 6
Chapter 04 Innate Immunity
pc pc pc 10
Chapter 05 Antibodies and Antigens
pc pc pc pc 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
pc pc pc pc pc pc pc pc pc pc pc
Histocompatibility Complex Molecules
pc pc 20
Chapter 07 Immune Receptors and Signal Transduction
pc pc pc pc pc pc 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
pc pc pc pc pc pc pc pc 30
Chapter 09 Activation of T Lymphocytes
pc pc pc pc pc 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
pc pc pc pc pc pc pc pc pc 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
pc pc pc pc pc pc pc pc pc 42
Chapter 12 B Cell Activation and Antibody Production
pc pc pc pc pc pc pc 46
Chapter 13 Effector Mechanisms of Humoral Immunity
pc pc pc pc pc pc 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
pc pc pc pc pc pc pc pc pc pc pc 56
Chapter 15 Immunologic Tolerance and Autoimmunity
pc pc pc pc pc 62
Chapter 16 Immunity to Microbes
pc pc pc pc 67
Chapter 17 Transplantation Immunology
pc pc pc 72
Chapter 18 Tumor Immunology
pc pc pc 77
Chapter 19 Hypersensitivity Disorders
pc pc pc 81
Chapter 20 Allergy
pc pc 86
Chapter 21 Primary and Acquired Immunodeficiencies
pc pc pc pc pc 89
,Chapter 01: Properties and Overview of Immune Responses
pc pc pc pc pc pc pc
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
pc pc pc pc pc pc pc pc pc
MULTIPLE CHOICE pc
1. The principal function of the immune system is:
pc pc pc pc pc pc pc
a. Defense against cancer pc pc
b. Repair of injured tissues pc pc pc
c. Defense against microbial infections pc pc pc
d. Prevention of inflammatory diseases pc pc pc
e. Protection against environmental toxins pc pc pc
ANS: C p c
The immune system has evolved in the setting of selective pressures imposed by microbia
pc pc pc pc pc pc pc pc pc pc pc pc pc
l infections. Although immune responses to cancer may occur, the concept that ―immuno
pc pc pc pc pc pc pc pc pc pc pc pc
surveillance‖ against cancer is a principal function of the immune system is controversial
pc pc pc pc pc pc pc pc pc pc pc pc
. Repair of injured tissues may be a secondary consequence of the immune responses and
pc pc pc pc pc pc pc pc pc pc pc pc pc pc
inflammation. Although the immune system has regulatory features that are needed to pr
pc pc pc pc pc pc pc pc pc pc pc pc pc
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
pc pc pc pc pc pc pc pc pc pc pc
ion. The immune system can protect against microbial toxins, but it generally does not off
pc pc pc pc pc pc pc pc pc pc pc pc pc pc
er protection against toxins of nonbiologic origin.
pc pc pc pc pc pc
2. Which of the following infectious diseases was prevented by the first successfu
pc pc pc pc pc pc pc pc pc pc pc
l vaccination?
pc
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p c
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
pc pc pc pc pc pc pc pc pc pc pc pc
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
pc pc pc pc pc pc pc pc pc pc pc pc pc pc pc
smallpox was reported to be eradicated worldwide by a vaccination program. Effective v
pc pc pc pc pc pc pc pc pc pc pc pc pc
accines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th ce
pc pc pc pc pc pc pc pc pc pc pc pc pc
ntury and are widely used. There is no effective vaccine against Mycobacterium tubercul
pc pc pc pc pc pc pc pc pc pc pc pc
osis.
3. Which of the following is a unique property of the adaptive immune system?
pc pc pc pc pc pc pc pc pc pc pc pc
a. Highly diverse repertoire of specificities for antigens
pc pc pc pc pc pc
b. Self-nonself discrimination pc
c. Recognition of microbial structures by both cell-associated and soluble receptors
pc pc pc pc pc pc pc pc pc
d. Protection against viral infections pc pc pc
e. Responses that have the same kinetics and magnitude on repeated exposure to th
pc pc pc pc pc pc pc pc pc pc pc pc
e same microbe pc pc
ANS: p c A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
pc pc pc pc pc pc pc pc pc pc pc pc pc pc
cytes, which are the central cellular components of the adaptive immune system. Both th
pc pc pc pc pc pc pc pc pc pc pc pc pc
e innate and the adaptive immune systems use cell-
pc pc pc pc pc pc pc pc
associated and soluble receptors to recognize microbes, display some degree of self-
pc pc pc pc pc pc pc pc pc pc pc
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
pc pc pc pc pc pc pc pc pc pc pc pc
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
pc pc pc pc pc pc pc pc pc pc pc pc pc
s the manifestation of memory.
pc pc pc pc
4. Antibodies and T lymphocytes are the respective mediators of which two types o
pc pc pc pc pc pc pc pc pc pc pc pc
f immunity?
pc
a. Innate and adaptive pc pc
b. Passive and active pc pc
c. Specific and nonspecific pc pc
d. Humoral and cell-mediated pc pc
e. Adult and neonatal pc pc
ANS: D p c
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
pc pc pc pc pc pc pc pc pc pc pc pc
s produce antibodies, which are the recognition and effector molecules of humoral immun
pc pc pc pc pc pc pc pc pc pc pc pc
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
pc pc pc pc pc pc pc pc pc pc pc pc
ellular pathogens in cell-
pc pc pc
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
pc pc pc pc pc pc pc pc pc pc pc pc pc pc pc
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
pc pc pc pc pc pc pc pc pc pc pc pc pc
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
pc pc pc pc pc pc pc pc pc pc pc pc pc
d.
5. The two major functional classes of effector T lymphocytes are:
pc pc pc pc pc pc pc pc pc
a. Helper T lymphocytes and cytotoxic T lymphocytes
pc pc pc pc pc pc
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
pc pc pc pc
c. Memory T cells and effector T cells pc pc pc pc pc pc
d. Helper cells and antigen-presenting cells pc pc pc pc
e. Cytotoxic T lymphocytes and target cells pc pc pc pc pc
ANS: A p c
T cells can be classified into effector subsets that perform different effector functions. Mos
pc pc pc pc pc pc pc pc pc pc pc pc pc
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
pc pc pc pc pc pc pc pc pc pc pc pc pc pc pc
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
pc pc pc pc pc pc pc pc pc pc pc pc
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
pc pc pc pc pc pc pc pc pc pc pc pc
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. pc pc pc pc pc pc pc pc pc pc pc pc pc pc
6. Which of the following cell types is required for all adaptive humoral immune responses?
pc pc pc pc pc pc pc pc pc pc pc pc pc
a. Natural killer cells pc pc
b. Dendritic cells pc
c. Cytolytic T lymphocytes pc pc
d. B lymphocytes pc
e. Helper T lymphocytes pc pc
ANS: D p c
Humoral immune responses are antibody- pc pc pc pc
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
pc pc pc pc pc pc pc pc pc pc pc pc pc
er cell type.
pc pc
Cellular and Molecular Immunology
pc pc pc
Abul Abbas, Andrew Lichtman, and Shiv Pillai
pc pc pc pc pc pc
10th Edition
pc
,Table of Contents
pc pc
Chapter 01 Properties and Overview of Immune Responses
pc pc pc pc pc pc pc 1
Chapter 02 Cells and Tissues of the Immune System
pc pc pc pc pc pc pc pc 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
pc pc pc pc pc pc pc 6
Chapter 04 Innate Immunity
pc pc pc 10
Chapter 05 Antibodies and Antigens
pc pc pc pc 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
pc pc pc pc pc pc pc pc pc pc pc
Histocompatibility Complex Molecules
pc pc 20
Chapter 07 Immune Receptors and Signal Transduction
pc pc pc pc pc pc 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
pc pc pc pc pc pc pc pc 30
Chapter 09 Activation of T Lymphocytes
pc pc pc pc pc 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
pc pc pc pc pc pc pc pc pc 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
pc pc pc pc pc pc pc pc pc 42
Chapter 12 B Cell Activation and Antibody Production
pc pc pc pc pc pc pc 46
Chapter 13 Effector Mechanisms of Humoral Immunity
pc pc pc pc pc pc 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
pc pc pc pc pc pc pc pc pc pc pc 56
Chapter 15 Immunologic Tolerance and Autoimmunity
pc pc pc pc pc 62
Chapter 16 Immunity to Microbes
pc pc pc pc 67
Chapter 17 Transplantation Immunology
pc pc pc 72
Chapter 18 Tumor Immunology
pc pc pc 77
Chapter 19 Hypersensitivity Disorders
pc pc pc 81
Chapter 20 Allergy
pc pc 86
Chapter 21 Primary and Acquired Immunodeficiencies
pc pc pc pc pc 89
,Chapter 01: Properties and Overview of Immune Responses
pc pc pc pc pc pc pc
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
pc pc pc pc pc pc pc pc pc
MULTIPLE CHOICE pc
1. The principal function of the immune system is:
pc pc pc pc pc pc pc
a. Defense against cancer pc pc
b. Repair of injured tissues pc pc pc
c. Defense against microbial infections pc pc pc
d. Prevention of inflammatory diseases pc pc pc
e. Protection against environmental toxins pc pc pc
ANS: C p c
The immune system has evolved in the setting of selective pressures imposed by microbia
pc pc pc pc pc pc pc pc pc pc pc pc pc
l infections. Although immune responses to cancer may occur, the concept that ―immuno
pc pc pc pc pc pc pc pc pc pc pc pc
surveillance‖ against cancer is a principal function of the immune system is controversial
pc pc pc pc pc pc pc pc pc pc pc pc
. Repair of injured tissues may be a secondary consequence of the immune responses and
pc pc pc pc pc pc pc pc pc pc pc pc pc pc
inflammation. Although the immune system has regulatory features that are needed to pr
pc pc pc pc pc pc pc pc pc pc pc pc pc
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
pc pc pc pc pc pc pc pc pc pc pc
ion. The immune system can protect against microbial toxins, but it generally does not off
pc pc pc pc pc pc pc pc pc pc pc pc pc pc
er protection against toxins of nonbiologic origin.
pc pc pc pc pc pc
2. Which of the following infectious diseases was prevented by the first successfu
pc pc pc pc pc pc pc pc pc pc pc
l vaccination?
pc
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p c
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
pc pc pc pc pc pc pc pc pc pc pc pc
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
pc pc pc pc pc pc pc pc pc pc pc pc pc pc pc
smallpox was reported to be eradicated worldwide by a vaccination program. Effective v
pc pc pc pc pc pc pc pc pc pc pc pc pc
accines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th ce
pc pc pc pc pc pc pc pc pc pc pc pc pc
ntury and are widely used. There is no effective vaccine against Mycobacterium tubercul
pc pc pc pc pc pc pc pc pc pc pc pc
osis.
3. Which of the following is a unique property of the adaptive immune system?
pc pc pc pc pc pc pc pc pc pc pc pc
a. Highly diverse repertoire of specificities for antigens
pc pc pc pc pc pc
b. Self-nonself discrimination pc
c. Recognition of microbial structures by both cell-associated and soluble receptors
pc pc pc pc pc pc pc pc pc
d. Protection against viral infections pc pc pc
e. Responses that have the same kinetics and magnitude on repeated exposure to th
pc pc pc pc pc pc pc pc pc pc pc pc
e same microbe pc pc
ANS: p c A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
pc pc pc pc pc pc pc pc pc pc pc pc pc pc
cytes, which are the central cellular components of the adaptive immune system. Both th
pc pc pc pc pc pc pc pc pc pc pc pc pc
e innate and the adaptive immune systems use cell-
pc pc pc pc pc pc pc pc
associated and soluble receptors to recognize microbes, display some degree of self-
pc pc pc pc pc pc pc pc pc pc pc
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
pc pc pc pc pc pc pc pc pc pc pc pc
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
pc pc pc pc pc pc pc pc pc pc pc pc pc
s the manifestation of memory.
pc pc pc pc
4. Antibodies and T lymphocytes are the respective mediators of which two types o
pc pc pc pc pc pc pc pc pc pc pc pc
f immunity?
pc
a. Innate and adaptive pc pc
b. Passive and active pc pc
c. Specific and nonspecific pc pc
d. Humoral and cell-mediated pc pc
e. Adult and neonatal pc pc
ANS: D p c
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
pc pc pc pc pc pc pc pc pc pc pc pc
s produce antibodies, which are the recognition and effector molecules of humoral immun
pc pc pc pc pc pc pc pc pc pc pc pc
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
pc pc pc pc pc pc pc pc pc pc pc pc
ellular pathogens in cell-
pc pc pc
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
pc pc pc pc pc pc pc pc pc pc pc pc pc pc pc
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
pc pc pc pc pc pc pc pc pc pc pc pc pc
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
pc pc pc pc pc pc pc pc pc pc pc pc pc
d.
5. The two major functional classes of effector T lymphocytes are:
pc pc pc pc pc pc pc pc pc
a. Helper T lymphocytes and cytotoxic T lymphocytes
pc pc pc pc pc pc
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
pc pc pc pc
c. Memory T cells and effector T cells pc pc pc pc pc pc
d. Helper cells and antigen-presenting cells pc pc pc pc
e. Cytotoxic T lymphocytes and target cells pc pc pc pc pc
ANS: A p c
T cells can be classified into effector subsets that perform different effector functions. Mos
pc pc pc pc pc pc pc pc pc pc pc pc pc
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
pc pc pc pc pc pc pc pc pc pc pc pc pc pc pc
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
pc pc pc pc pc pc pc pc pc pc pc pc
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
pc pc pc pc pc pc pc pc pc pc pc pc
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. pc pc pc pc pc pc pc pc pc pc pc pc pc pc
6. Which of the following cell types is required for all adaptive humoral immune responses?
pc pc pc pc pc pc pc pc pc pc pc pc pc
a. Natural killer cells pc pc
b. Dendritic cells pc
c. Cytolytic T lymphocytes pc pc
d. B lymphocytes pc
e. Helper T lymphocytes pc pc
ANS: D p c
Humoral immune responses are antibody- pc pc pc pc
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
pc pc pc pc pc pc pc pc pc pc pc pc pc
er cell type.
pc pc
