Exam Questions and Answers | A+ Score
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corticosteroid drugs - 🧠 ANSWER ✔✔prednisone, methylprednisolone,
dexamethasone, topical such as hydrocortisone, and then joint injections
for pain
MOA of corticosteroids drugs - 🧠 ANSWER ✔✔drugs that suppress
inflammation by mimicking glucocorticoid hormones
Inhibit interleikin one, tumor necrosis factor and other cytokines, impairs
phagocytosis, impairs lymphocytes, and inhibits tissue repair
indications for cortocosteriod use - 🧠 ANSWER ✔✔Allergy or
hypersensitivity, respiratory, shock, rheumatology, neurology, hepatic,
neoplastic... basicly every organ is covered if there is an issue.
,withdrawal from corticorsteriod symptoms - 🧠 ANSWER ✔✔malaise,
myalgia, headache, nausea, fevers, hypotension and relapse of symptoms
(pain, inflammation, ashtma)
what must you do with corticosteriods to prevent withdrawal - 🧠 ANSWER
✔✔Must taper them down, you can have possible adrenal crisis if you do
not.
corticosteriod considerations - 🧠 ANSWER ✔✔suppression patients
response to infections- no live viral vaccines, and have increased
susceptibility to disease.
If used over 6 months: Increase blood glucose, impair immune function (get
vaccines) , impair wound healing, GI complaints (report black tarry stools) ,
osteoporosis (decreases calcium), anxiety/insomnia, sodium & fluid
retention 9monitor weight and fluid retention)
If on 1gram or more also prescribe PPI (omeprazole) to prevent PUD
contraindicated with active infection and hypersensitivity
,What are the adverse effects of corticosteroids if administered for six
months or more? - 🧠 ANSWER ✔✔The main thing you want to worry about
is osteoporosis
It can also worsen diabetic control
Patients should report any tarry black stools or abdominal pain.
NSAIDS - 🧠 ANSWER ✔✔nonsteroidal anti-inflammatory drugs
Ibprofen, aspirin, torsdol, naproxin, Mobic
Arachidonic Acid Cascade - 🧠 ANSWER ✔✔Cell membrane ►
Arachinidonic acid ► Cycloxygenerase (COX)► prostaglandin's
Or
Cell membrane ► Arachinidonic acid ► Lipoxygenase► Leukotrines
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, NSAID mechanism of action - 🧠 ANSWER ✔✔• NSAIDs inhibit the
enzymes COX I and II
• Results in reduction in formation of prostaglandin precursors and
thromboxanes from arachidonic acid
COX1- ibuprofen, naproxen, aspirin, when this is inhibited you are also
inhibiting the prostaglandins that protect the stomach
COX2 - celebrex more stomach proctective
Drug interactions with NSAIDS - 🧠 ANSWER ✔✔Pretty much anything that
is highly protien bound. Do not give together with
ACE inhibitors - counteracts antihypertensive effect
BetaBlockers - counteracts antihypertensive effect
lithium - increases lithium levels