, 2
Contents
Chapter 01: Cellular Biology ................................................................................................... 4
Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents......................... 18
Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases .......... 31
Chapter 04: Genes and Genetic Diseases ............................................................................ 44
Chapter 05: Genes, Environment-Lifestyle, and Common Diseases .................................55
Chapter 06: Epigenetics and Disease .................................................................................. 63
Chapter 07: Innate Immunity: Inflammation and Wound Healing .................................. 68
Chapter 08: Adaptive Immunity .......................................................................................... 83
Chapter 09: Alterations in Immunity and Inflammation .................................................. 95
Chapter 10: Infection .......................................................................................................... 108
Chapter 11: Stress and Disease ............................................................................................ 117
Chapter 12: Cancer Biology..................................................................................................124
Chapter 13: Cancer Epidemiology ....................................................................................... 137
Chapter 14: Cancer in Children ...........................................................................................143
Chapter 15: Structure and Function of the Neurologic System........................................ 148
Chapter 16: Pain, Temperature Regulation, Sleep, and Sensory Function ...................... 159
Chapter 17: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor
Function ................................................................................................................................ 174
Chapter 18: Disorders of the Central and Peripheral Nervous Systems and the
Neuromuscular Junction
......................................................................................................................................................
............ 188
Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders ..199
, 3
Chapter 20: Alterations of Neurologic Function in Children ........................................... 206
Chapter 21: Mechanisms of Hormonal Regulation............................................................213
Chapter 22: Alterations of Hormonal Regulation ............................................................. 222
Chapter 23: Obesity and Disorders of Nutrition ............................................................... 234
Chapter 24: Structure and Function of the Reproductive Systems ................................. 239
Chapter 25: Alterations of the Female Reproductive System .......................................... 249
Chapter 26: Alterations of the Male Reproductive System .............................................. 259
Chapter 27: Sexually Transmitted Infections.................................................................... 265
Chapter 28: Structure and Function of the Hematologic System.................................... 273
Chapter 29: Alterations of Erythrocytes, Platelets, and Hemostatic Function............... 283
Chapter 30: Alterations of Leukocyte and Lymphoid Function ...................................... 293
Chapter 31: Alterations of Hematologic Function in Children ........................................ 300
Chapter 32: Structure and Function of the Cardiovascular and Lymphatic Systems ..... 311
Chapter 33: Alterations of Cardiovascular Function ........................................................ 324
Chapter 34: Alterations of Cardiovascular Function in Children .................................... 338
Chapter 35: Structure and Function of the Pulmonary System ....................................... 346
Chapter 36: Alterations of Pulmonary Function ............................................................... 356
Chapter 37: Alterations of Pulmonary Function in Children ........................................... 373
Chapter 38: Structure and Function of the Renal and Urologic Systems ....................... 381
Chapter 39: Alterations of Renal and Urinary Tract Function .........................................391
Chapter 40: Alterations of Renal and Urinary Tract Function in Children .................... 401
Chapter 41: Structure and Function of the Digestive System .......................................... 409
Chapter 42: Alterations of Digestive Function ...................................................................421
Chapter 43: Alterations of Digestive Function in Children.............................................. 432
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Chapter 44: Structure and Function of the Musculoskeletal System ...............................441
Chapter 45: Alterations of Musculoskeletal Function ...................................................... 453
Chapter 46: Alterations of Musculoskeletal Function in Children .................................. 466
Chapter 47: Structure, Function, and Disorders of the Integument ............................... 475
Chapter 48: Alterations of the Integument in Children ................................................... 486
Chapter 49: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults........ 494
Chapter 50: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children .... 502
Contents
Chapter 01: Cellular Biology ................................................................................................... 4
Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents......................... 18
Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases .......... 31
Chapter 04: Genes and Genetic Diseases ............................................................................ 44
Chapter 05: Genes, Environment-Lifestyle, and Common Diseases .................................55
Chapter 06: Epigenetics and Disease .................................................................................. 63
Chapter 07: Innate Immunity: Inflammation and Wound Healing .................................. 68
Chapter 08: Adaptive Immunity .......................................................................................... 83
Chapter 09: Alterations in Immunity and Inflammation .................................................. 95
Chapter 10: Infection .......................................................................................................... 108
Chapter 11: Stress and Disease ............................................................................................ 117
Chapter 12: Cancer Biology..................................................................................................124
Chapter 13: Cancer Epidemiology ....................................................................................... 137
Chapter 14: Cancer in Children ...........................................................................................143
Chapter 15: Structure and Function of the Neurologic System........................................ 148
Chapter 16: Pain, Temperature Regulation, Sleep, and Sensory Function ...................... 159
Chapter 17: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor
Function ................................................................................................................................ 174
Chapter 18: Disorders of the Central and Peripheral Nervous Systems and the
Neuromuscular Junction
......................................................................................................................................................
............ 188
Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders ..199
, 3
Chapter 20: Alterations of Neurologic Function in Children ........................................... 206
Chapter 21: Mechanisms of Hormonal Regulation............................................................213
Chapter 22: Alterations of Hormonal Regulation ............................................................. 222
Chapter 23: Obesity and Disorders of Nutrition ............................................................... 234
Chapter 24: Structure and Function of the Reproductive Systems ................................. 239
Chapter 25: Alterations of the Female Reproductive System .......................................... 249
Chapter 26: Alterations of the Male Reproductive System .............................................. 259
Chapter 27: Sexually Transmitted Infections.................................................................... 265
Chapter 28: Structure and Function of the Hematologic System.................................... 273
Chapter 29: Alterations of Erythrocytes, Platelets, and Hemostatic Function............... 283
Chapter 30: Alterations of Leukocyte and Lymphoid Function ...................................... 293
Chapter 31: Alterations of Hematologic Function in Children ........................................ 300
Chapter 32: Structure and Function of the Cardiovascular and Lymphatic Systems ..... 311
Chapter 33: Alterations of Cardiovascular Function ........................................................ 324
Chapter 34: Alterations of Cardiovascular Function in Children .................................... 338
Chapter 35: Structure and Function of the Pulmonary System ....................................... 346
Chapter 36: Alterations of Pulmonary Function ............................................................... 356
Chapter 37: Alterations of Pulmonary Function in Children ........................................... 373
Chapter 38: Structure and Function of the Renal and Urologic Systems ....................... 381
Chapter 39: Alterations of Renal and Urinary Tract Function .........................................391
Chapter 40: Alterations of Renal and Urinary Tract Function in Children .................... 401
Chapter 41: Structure and Function of the Digestive System .......................................... 409
Chapter 42: Alterations of Digestive Function ...................................................................421
Chapter 43: Alterations of Digestive Function in Children.............................................. 432
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Chapter 44: Structure and Function of the Musculoskeletal System ...............................441
Chapter 45: Alterations of Musculoskeletal Function ...................................................... 453
Chapter 46: Alterations of Musculoskeletal Function in Children .................................. 466
Chapter 47: Structure, Function, and Disorders of the Integument ............................... 475
Chapter 48: Alterations of the Integument in Children ................................................... 486
Chapter 49: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults........ 494
Chapter 50: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children .... 502
