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Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
ss ss ss ss ss ss ss ss ss ss
Multiple Choice ss
Identify the choice that best completes the statement or answers the question.
ss s s s s s s s s s s ss s s ss s s s s
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
ss s s ss ss ss s s s s s s s s ss ss s s s s
a. Pentose phosphate shunt c. Glycolysis s s s s
b. Luebering-Rapoport shunt d. Methemoglobin reductase ss s s
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the
ss s s s s s s s s s s s s s s s s s s s s s s s s ss ss
patient’s IV failed. The unit of blood was outside the blood bank for 35 minutes.
s s s s ss s s s s s s s s s s s s s s s s s s s s s s s s
Which of the statements below is most accurate?
s s s s s s s s ss s s s s s s
a. The unit of blood should be discarded immediately. ss s s s s s s s s s s ss
b. The unit of blood can be returned to inventory. s s s s s s s s s s s s s s s s
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that
ss s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s
time. s s
d. The unit of blood must be transfused with 24 hours.s s s s s s s s s s s s s s s s s s
3. What is the average diameter of a platelet?
s s s s s s s s s s s s s s
a. 5 to 10 µm c. 1 to 2 µm
s s s s s s s s s s s s
b. 2 to 4 µm d.
s s 4 to 6 µm s s s s s s s s s s
4. In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is
s s s s s s s s s s s s s s s s s s mm
released to the tissues when PO2 averages 40 mm Hg?
s s s s s s ss s s s s s s s s s s
a. 75% c. 100%
b. 25% d. 50%
5. What factors are known to influence platelet metabolism and function?
ss s s s s s s s s s s s s ss s s
a. Storage temperature c. Platelet count s s ss
b. Initial pH d. All of the above s s s s s s mm
6. Which of the following red blood cell morphologies may be present on the peripheral
s s s s s s s s s s s s s s s s s s mm s s s s s s
blood smear as a result of loss of RBC membrane?
s s s s ss s s s s s s s s s s s s s s
a. Spherocytes c. Burr cells mm
b. Target cells d. Schistocytes ss
7. What does the term autologous transfusion refer to?
s s s s s s s s s s mm s s
a. A parent donating blood for his or her child
ss s s mm s s s s s s s s s s
b. An individual donating blood for a friend s s s s s s s s mm s s
c. An individual donating blood for a relative s s mm s s mm s s s s
d. An individual donating blood for his or her own transfusion
s s mm s s s s mm s s s s s s s s
8. What is the primary function of hemoglobin?
mm mm s s ss mm mm
a. Iron metabolism c. Oxygen transport
s s ss
b. Porphyrin synthesis d. Signal transduction s s s s
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival
s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s
except: s s
a. Cellular metabolism. c. Site of the ABO antigen attachment. s s ss s s ss ss s s
b. RBC membrane. d. Hemoglobin structure.
s s s s
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10. What is the correct biochemical composition of the RBC membrane?
s s s s s s s s s s s s s s s s s s
a. 52% protein, 40% lipid, 8% carbohydrate
s s s s s s s s s s
b. 40% protein, 8% lipid, 52% carbohydrate
s s s s s s s s s s
c. 8% protein, 52% lipid, 40% carbohydrate
s s s s s s s s s s
d. 8% lipid, 40% carbohydrate, 52% protein
s s s s s s s s s s
11. All of the following biochemical changes are associated with loss of red blood cell
s s s s s s s s s s s s s s s s s s s s s s s s s s
storage viability upon
s s ss
except:
a. Decreased pH. s s c. Increased ATP level. ss ss
b. Loss of red blood cell function.
s s s s s s s s s s d. Decreased glucose consumption. s s s s
12. Which red blood cell preservative has a storage time
s s s s s s s s s s s s s s s s s s of 35 days? s s s s
a. ACD c. AS-1
b. CPDA-1 d. CPD
13. The RBC membrane is relatively permeable to all of the following except:
s s s s s s s s s s s s s s s s s s s s s s
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water.
14. What percentage of platelets is sequestered in the spleen as functional reserve after
s s s s s s s s s s s s s s s s s s s s s s s s
being released from the bone marrow?
s s s s ss s s s s s s
a. 30% c. 10%
b. 50% d. 25%
15. What is the major biochemical consideration in platelet storage?
s s s s s s s s s s mm s s s s
a. Glucose metabolism c. Production of carbon dioxide
s s s s s s mm
b. Oxygen supply d. Regulation of pH
s s ssm s s m s s mm mm
16. What would the hemoglobin-oxygen dissociation curve depict in a patient
s s s s s s s s s s s s s s s s s s
exhibiting clinical signs of alkalosis?
s s s s ss s s s s
a. Normal c. Shift to the right s s s s s s
b. Shift to the left s sd. None of the aboves s s s s s s s s s
17. Name the main lipid components of a red blood cell membrane.
s s s s s s mm s s s s mm s s s s s s
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A ss
18. The ABO blood groups ss s s mm s s were discovered in 1901 by whom?
mm s s s s s s s s
a. Charles Drew mm c. Loutit and Mollison s s s s
b. Karl Landsteiner mm d. Edward Lindeman s s
19. A standing order of platelets was shipped to your facility by your supplier. It was
s s s s s s s s s s s s s s s s s s s s s s s s s s s s
inadvertently left in the corner of the department until discovered 36 hours later. What
s s ss s s s s s s mm mm s s s s s s s s s s s s s s
would the appropriate action be for the blood banker?
s s s s s s ss s s ss s s mm s s
a. If the temperature in the box was 22 +/- 2°C and the platelet swirl
s s s s s s s s s s s s s s s s ss s s s s s s s s
seemed OK, it would be OK to accept the unit into inventory.
s s s s s s ss s s s s s s s s s s s s s s s s
b. The platelets have fallen outside the supplier’s quality assurance. The
s s s s s s s s s s s s s s s s s s
unit should be discarded because the pH has probably dropped too
s s ss s s s s s s s s s s s s s s ss s s
low and platelet activation has been compromised.
s s s s s s ss s s s s s s
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK
s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s
This study source
s s s s s s was s s downloaded s s by s s 100000826342158 s s from s s CourseHero.com s s on s s 09-15-
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s s t
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This study source
s s s s s s was s s downloaded s s by s s 100000826342158 s s from s s CourseHero.com s s on s s 09-15-
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Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
ss ss ss ss ss ss ss ss ss ss
Multiple Choice ss
Identify the choice that best completes the statement or answers the question.
ss s s s s s s s s s s ss s s ss s s s s
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
ss s s ss ss ss s s s s s s s s ss ss s s s s
a. Pentose phosphate shunt c. Glycolysis s s s s
b. Luebering-Rapoport shunt d. Methemoglobin reductase ss s s
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the
ss s s s s s s s s s s s s s s s s s s s s s s s s ss ss
patient’s IV failed. The unit of blood was outside the blood bank for 35 minutes.
s s s s ss s s s s s s s s s s s s s s s s s s s s s s s s
Which of the statements below is most accurate?
s s s s s s s s ss s s s s s s
a. The unit of blood should be discarded immediately. ss s s s s s s s s s s ss
b. The unit of blood can be returned to inventory. s s s s s s s s s s s s s s s s
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that
ss s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s
time. s s
d. The unit of blood must be transfused with 24 hours.s s s s s s s s s s s s s s s s s s
3. What is the average diameter of a platelet?
s s s s s s s s s s s s s s
a. 5 to 10 µm c. 1 to 2 µm
s s s s s s s s s s s s
b. 2 to 4 µm d.
s s 4 to 6 µm s s s s s s s s s s
4. In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is
s s s s s s s s s s s s s s s s s s mm
released to the tissues when PO2 averages 40 mm Hg?
s s s s s s ss s s s s s s s s s s
a. 75% c. 100%
b. 25% d. 50%
5. What factors are known to influence platelet metabolism and function?
ss s s s s s s s s s s s s ss s s
a. Storage temperature c. Platelet count s s ss
b. Initial pH d. All of the above s s s s s s mm
6. Which of the following red blood cell morphologies may be present on the peripheral
s s s s s s s s s s s s s s s s s s mm s s s s s s
blood smear as a result of loss of RBC membrane?
s s s s ss s s s s s s s s s s s s s s
a. Spherocytes c. Burr cells mm
b. Target cells d. Schistocytes ss
7. What does the term autologous transfusion refer to?
s s s s s s s s s s mm s s
a. A parent donating blood for his or her child
ss s s mm s s s s s s s s s s
b. An individual donating blood for a friend s s s s s s s s mm s s
c. An individual donating blood for a relative s s mm s s mm s s s s
d. An individual donating blood for his or her own transfusion
s s mm s s s s mm s s s s s s s s
8. What is the primary function of hemoglobin?
mm mm s s ss mm mm
a. Iron metabolism c. Oxygen transport
s s ss
b. Porphyrin synthesis d. Signal transduction s s s s
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival
s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s
except: s s
a. Cellular metabolism. c. Site of the ABO antigen attachment. s s ss s s ss ss s s
b. RBC membrane. d. Hemoglobin structure.
s s s s
This study source
s s s s s s was s s downloaded s s by s s 100000826342158 s s from s s CourseHero.com s s on s s 09-15-
2021 17:54:15
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10. What is the correct biochemical composition of the RBC membrane?
s s s s s s s s s s s s s s s s s s
a. 52% protein, 40% lipid, 8% carbohydrate
s s s s s s s s s s
b. 40% protein, 8% lipid, 52% carbohydrate
s s s s s s s s s s
c. 8% protein, 52% lipid, 40% carbohydrate
s s s s s s s s s s
d. 8% lipid, 40% carbohydrate, 52% protein
s s s s s s s s s s
11. All of the following biochemical changes are associated with loss of red blood cell
s s s s s s s s s s s s s s s s s s s s s s s s s s
storage viability upon
s s ss
except:
a. Decreased pH. s s c. Increased ATP level. ss ss
b. Loss of red blood cell function.
s s s s s s s s s s d. Decreased glucose consumption. s s s s
12. Which red blood cell preservative has a storage time
s s s s s s s s s s s s s s s s s s of 35 days? s s s s
a. ACD c. AS-1
b. CPDA-1 d. CPD
13. The RBC membrane is relatively permeable to all of the following except:
s s s s s s s s s s s s s s s s s s s s s s
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water.
14. What percentage of platelets is sequestered in the spleen as functional reserve after
s s s s s s s s s s s s s s s s s s s s s s s s
being released from the bone marrow?
s s s s ss s s s s s s
a. 30% c. 10%
b. 50% d. 25%
15. What is the major biochemical consideration in platelet storage?
s s s s s s s s s s mm s s s s
a. Glucose metabolism c. Production of carbon dioxide
s s s s s s mm
b. Oxygen supply d. Regulation of pH
s s ssm s s m s s mm mm
16. What would the hemoglobin-oxygen dissociation curve depict in a patient
s s s s s s s s s s s s s s s s s s
exhibiting clinical signs of alkalosis?
s s s s ss s s s s
a. Normal c. Shift to the right s s s s s s
b. Shift to the left s sd. None of the aboves s s s s s s s s s
17. Name the main lipid components of a red blood cell membrane.
s s s s s s mm s s s s mm s s s s s s
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A ss
18. The ABO blood groups ss s s mm s s were discovered in 1901 by whom?
mm s s s s s s s s
a. Charles Drew mm c. Loutit and Mollison s s s s
b. Karl Landsteiner mm d. Edward Lindeman s s
19. A standing order of platelets was shipped to your facility by your supplier. It was
s s s s s s s s s s s s s s s s s s s s s s s s s s s s
inadvertently left in the corner of the department until discovered 36 hours later. What
s s ss s s s s s s mm mm s s s s s s s s s s s s s s
would the appropriate action be for the blood banker?
s s s s s s ss s s ss s s mm s s
a. If the temperature in the box was 22 +/- 2°C and the platelet swirl
s s s s s s s s s s s s s s s s ss s s s s s s s s
seemed OK, it would be OK to accept the unit into inventory.
s s s s s s ss s s s s s s s s s s s s s s s s
b. The platelets have fallen outside the supplier’s quality assurance. The
s s s s s s s s s s s s s s s s s s
unit should be discarded because the pH has probably dropped too
s s ss s s s s s s s s s s s s s s ss s s
low and platelet activation has been compromised.
s s s s s s ss s s s s s s
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK
s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s
This study source
s s s s s s was s s downloaded s s by s s 100000826342158 s s from s s CourseHero.com s s on s s 09-15-
2021 17:54:15
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s s t
o
This study source
s s s s s s was s s downloaded s s by s s 100000826342158 s s from s s CourseHero.com s s on s s 09-15-
2021 17:54:15
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