NR 546 / NR546 Actual Final
Exam 2025/2026 Prediction
Questions (All correct
Answers, Already Graded A)
Section 1: Neurotransmitters and Psychopharmacology
(Questions 1–10)
1. Which neurotransmitter is associated with excess activity in schizophrenia, epilepsy,
and mania?
A. Serotonin
B. Dopamine
C. GABA
D. Norepinephrine
Answer: Dopamine
Rationale: Excess dopamine activity is linked to schizophrenia (positive symptoms),
epilepsy (seizure activity), and mania (hyperactivity).
2. What is the primary role of the monoamine hypothesis in depression?
A. Excess serotonin causes depression
B. Deficiency in monoamine neurotransmission contributes to depression
C. Increased GABA leads to mood stabilization
D. Dopamine excess causes mood swings
Answer: Deficiency in monoamine neurotransmission contributes to depression
Rationale: The monoamine hypothesis posits that depression results from reduced
serotonin, norepinephrine, and/or dopamine activity.
3. Which enzyme metabolizes many psychotropic medications in the liver?
A. Monoamine oxidase
B. Cytochrome P450
C. Acetylcholinesterase
D. Catechol-O-methyltransferase
, Answer: Cytochrome P450
Rationale: The cytochrome P450 system metabolizes most psychotropic medications,
affecting their efficacy and interactions.
4. What is the effect of serotonin syndrome? (Select all that apply)
A. Hyperthermia
B. Tremors
C. Confusion
D. Bradycardia
E. Agitation
Answer: Hyperthermia, Tremors, Confusion, Agitation
Rationale: Serotonin syndrome, caused by excessive serotonergic activity, presents with
hyperthermia, tremors, confusion, and agitation. Bradycardia is not typical.
5. How does genetic testing guide psychotropic medication selection?
A. It predicts client compliance
B. It identifies cytochrome P450 metabolism variations
C. It determines exact dosing schedules
D. It assesses psychological resilience
Answer: It identifies cytochrome P450 metabolism variations
Rationale: Genetic testing reveals cytochrome P450 variations, predicting how clients
metabolize psychotropic medications.
6. Which neurotransmitter is primarily targeted by benzodiazepines?
A. Dopamine
B. Serotonin
C. GABA
D. Glutamate
Answer: GABA
Rationale: Benzodiazepines enhance GABA activity, promoting sedation and anxiolysis.
7. What is a risk of combining two serotonergic drugs?
A. Hypoglycemia
B. Serotonin syndrome
C. QTc prolongation
D. Seizures
Answer: Serotonin syndrome
Rationale: Combining serotonergic drugs increases the risk of serotonin syndrome due to
excessive serotonin activity.
8. What is the primary function of norepinephrine in mood regulation?
A. Enhances memory consolidation
Exam 2025/2026 Prediction
Questions (All correct
Answers, Already Graded A)
Section 1: Neurotransmitters and Psychopharmacology
(Questions 1–10)
1. Which neurotransmitter is associated with excess activity in schizophrenia, epilepsy,
and mania?
A. Serotonin
B. Dopamine
C. GABA
D. Norepinephrine
Answer: Dopamine
Rationale: Excess dopamine activity is linked to schizophrenia (positive symptoms),
epilepsy (seizure activity), and mania (hyperactivity).
2. What is the primary role of the monoamine hypothesis in depression?
A. Excess serotonin causes depression
B. Deficiency in monoamine neurotransmission contributes to depression
C. Increased GABA leads to mood stabilization
D. Dopamine excess causes mood swings
Answer: Deficiency in monoamine neurotransmission contributes to depression
Rationale: The monoamine hypothesis posits that depression results from reduced
serotonin, norepinephrine, and/or dopamine activity.
3. Which enzyme metabolizes many psychotropic medications in the liver?
A. Monoamine oxidase
B. Cytochrome P450
C. Acetylcholinesterase
D. Catechol-O-methyltransferase
, Answer: Cytochrome P450
Rationale: The cytochrome P450 system metabolizes most psychotropic medications,
affecting their efficacy and interactions.
4. What is the effect of serotonin syndrome? (Select all that apply)
A. Hyperthermia
B. Tremors
C. Confusion
D. Bradycardia
E. Agitation
Answer: Hyperthermia, Tremors, Confusion, Agitation
Rationale: Serotonin syndrome, caused by excessive serotonergic activity, presents with
hyperthermia, tremors, confusion, and agitation. Bradycardia is not typical.
5. How does genetic testing guide psychotropic medication selection?
A. It predicts client compliance
B. It identifies cytochrome P450 metabolism variations
C. It determines exact dosing schedules
D. It assesses psychological resilience
Answer: It identifies cytochrome P450 metabolism variations
Rationale: Genetic testing reveals cytochrome P450 variations, predicting how clients
metabolize psychotropic medications.
6. Which neurotransmitter is primarily targeted by benzodiazepines?
A. Dopamine
B. Serotonin
C. GABA
D. Glutamate
Answer: GABA
Rationale: Benzodiazepines enhance GABA activity, promoting sedation and anxiolysis.
7. What is a risk of combining two serotonergic drugs?
A. Hypoglycemia
B. Serotonin syndrome
C. QTc prolongation
D. Seizures
Answer: Serotonin syndrome
Rationale: Combining serotonergic drugs increases the risk of serotonin syndrome due to
excessive serotonin activity.
8. What is the primary function of norepinephrine in mood regulation?
A. Enhances memory consolidation
