Guide
1. Receptors Norepinephrine-Adrenergic (adrenergic
comes from the word adrenalin)
Alpha 1-all sympathetic target organs ex-
cept the heart-constrict the blood vessels
and dilation of pupils
Alpha 2-Presynaptic adrenergic nerve ter-
minal-inhibits the release of norepineph-
rine
Beta 1-Heart and Kidneys (BETA 1-ONE
HEART)-increased heart rate and force of
contraction, release of renin
Beta 2-All sympathetic target organs-in-
hibits smooth muscle (BETA 2-TWO
LUNGS)
2. Beta blockers/olol's Beta-Adrenergic Blockers
Metoprolol/Lopressor ENDING OLOL
Beta Blockers are use with heart failure,
hypertension, angina and with myocardial
infarctions.
Action = Blocks Beta-Receptors in the heart
causing...
Decreases = HR, force of contraction, Rate
of atrioventricular (AV) conduction
SE = Bradycardia, lethargy, GI disturbance,
congestive heart failure, decrease BP, de-
pression
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Guide
The beta blockers stop sympathetic ner-
vous system stimulation of the heart. Does
not allow the heart rate and blood pressure
to rise with stress thus lowering the oxygen
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Guide
demand of the heart. It is very heart pro-
tective!
Will slow the heart rate and lower the blood
pressure
Can have beta 2 blockage with larger dos-
es-will constrict the bronchioles-watch for
clients with known COPD, Asthma
Nursing Interventions
Check pulse-needs to be 60 or above
Check blood pressure-if hypotensive do
not give (Systolic below 100 is a good rule
of thumb I go by)
Monitor for sexual dysfunction-impotence
for men-a good reason for non-compli-
ance
Drowsiness/Fatigue-operating heavy ma-
chinery, driving could put client at risk
Insomnia-
Contraindicated with Heart Blocks, Brady-
cardia, Worsening Heart Failure
Increases Hypoglycemic ettect of In-
sulin-monitor blood sugars and for hy-
poglycemia, may need to lower insulin
dosage
Beta Blockers have to be weaned slow-
ly to prevent rebound hypertension and
tachycardia-if a client wants to stop his
beta-blocker they need to contract their
physician
3. CCB,/calcium channel blockers
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Guide
Nifedipine/Adalat/Procardia/Norvasc-con-
trols blood vessels
Diltiazem/Cardizem
Verapamil/Calan/Isoptin/Verelan-controls
heart rate and blood vessels
Angina/Raynaud's/Vasospastic Angi-
na/Atrial Arrhythmia's
Blocks calcium channels in the myocardial
and vascular smooth muscles, decreases
the contraction of smooth muscle-relaxes
the arteries-vasodilation. Blocking of calci-
um channels in the SA and AV node-Slows
conduction through the SA and AV node.
Decreases the force of contraction slows
heart rate
Grapefruit juice may increase absorption
of nifedipine
Side Ettects: Relaxes smooth muscle and
cardiac muscle-
Headache
Dizziness-Take lying, sitting and standing
B/P, educate client to sit and stand slowly
Peripheral edema-assess for edema, mon-
itor for worsening (diuretic)
Flushing
Reflex tachycardia-monitor for elevated
heart rate (may need a BB)
Constipation-increase fibers and fluids (if