PATHOPHYSIOLOGY
THEBIOLOGICBASISFORDISEASEINADULTSANDCHILDREN
I.U I.U I.U I.U I.U I.U I.U I.U
8thEdition
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KathrynL.McCance,SueE.Huether
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Contents
Chapter01:CellularBiology ............................................................................................................................4
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Chapter02:Altered CellularandTissueBiology:Environmental Agents............................................................18
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Chapter03:TheCellularEnvironment:Fluids andElectrolytes, AcidsandBases ................................................31
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Chapter04:GenesandGeneticDiseases ........................................................................................................44
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Chapter05:Genes, Environment-Lifestyle,and Common Diseases .................................................................55
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Chapter06:EpigeneticsandDisease ..............................................................................................................63
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Chapter07:InnateImmunity:InflammationandWoundHealing.....................................................................68
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Chapter08:Adaptive Immunity ....................................................................................................................83
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Chapter09:Alterationsin Immunity andInflammation ...................................................................................95
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Chapter10:Infection .................................................................................................................................108
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Chapter11:StressandDisease ....................................................................................................................117
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Chapter12:CancerBiology .........................................................................................................................124
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Chapter13:CancerEpidemiology ...............................................................................................................137
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Chapter14:CancerinChildren ....................................................................................................................143
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Chapter15:Structure andFunction oftheNeurologicSystem .......................................................................148
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Chapter16:Pain,Temperature Regulation,Sleep,andSensory Function .......................................................159
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Chapter17:AlterationsinCognitive Systems,Cerebral Hemodynamics,and Motor Function ........................174
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Chapter18:Disordersofthe CentralandPeripheral Nervous Systems andthe Neuromuscular Junction
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. ............................................................................................................................................................ 188
Chapter19:Neurobiologyof Schizophrenia,MoodDisorders,andAnxietyDisorders ......................................199
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Chapter 20: Alterations ofNeurologicFunction inChildren ...........................................................................206
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Chapter21:MechanismsofHormonalRegulation .......................................................................................213
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Chapter22:Alterations ofHormonalRegulation .........................................................................................222
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Chapter23:Obesity andDisordersofNutrition .............................................................................................234
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Chapter24:Structure andFunctionoftheReproductive Systems..................................................................239
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Chapter25:Alterationsofthe Female Reproductive System .........................................................................249
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Chapter26:Alterationsofthe Male Reproductive System .............................................................................259
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Chapter27:Sexually Transmitted Infections ................................................................................................265
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Chapter28:Structure andFunction oftheHematologic System ....................................................................273
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Chapter29:AlterationsofErythrocytes,Platelets, andHemostatic Function .................................................283
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Chapter30:AlterationsofLeukocyte andLymphoidFunction........................................................................293
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Chapter31:AlterationsofHematologic Functionin Children .........................................................................300
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Chapter32:Structure andFunctionoftheCardiovascular andLymphatic Systems..........................................311
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Chapter33:AlterationsofCardiovascular Function .....................................................................................324
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Chapter34:AlterationsofCardiovascular FunctioninChildren ......................................................................338
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Chapter35:StructureandFunctionofthePulmonary System ......................................................................346
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Chapter 36:Alterations ofPulmonary Function ...........................................................................................356
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Chapter37:Alterations ofPulmonaryFunctioninChildren ...........................................................................373
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Chapter38:Structure andFunctionoftheRenal andUrologic Systems ...........................................................381
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Chapter 39:Alterations ofRenal and UrinaryTract Function .........................................................................391
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Chapter40:AlterationsofRenalandUrinaryTractFunctionin Children...........................................................401
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Chapter41:StructureandFunctionoftheDigestiveSystem .........................................................................409
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Chapter42:AlterationsofDigestive Function ..............................................................................................421
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Chapter43:AlterationsofDigestive FunctioninChildren ..............................................................................432
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Chapter44: Structure andFunctionoftheMusculoskeletal System ..............................................................441
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Chapter45:AlterationsofMusculoskeletal Function ...................................................................................453
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Chapter46:AlterationsofMusculoskeletal Functionin Children ...................................................................466
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Chapter47:Structure, Function,andDisordersoftheIntegument .................................................................475
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Chapter48:Alterationsofthe Integumentin Children ...................................................................................486
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Chapter49:Shock,MultipleOrganDysfunctionSyndrome, andBurnsinAdults...............................................494
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Chapter50:Shock,MultipleOrganDysfunctionSyndrome, andBurnsinChildren ...........................................502
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, TestBank-Pathophysiology:TheBiologicBasisforDiseaseinAdultsandChildren(8th)
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Chapter01:CellularBiology i.u
MULTIPLECHOICE i.u
1. Whichstatementbestdescribesthecellularfunctionofmetabolicabsorption? i.u i.u i.u i.u i.u i.u i.u i.u i.u
a. Cellscanproduceproteins. i.u i.u i.u
b. Cellscansecretedigestiveenzymes. i.u i.u i.u i.u
c. Cellscantakeinandusenutrients. i.u i.u i.u i.u i.u
d. Cellscansynthesizefats. i.u i.u i.u
ANS: C i . u
Inmetabolicabsorption,allcellstakeinandusenutrientsandothersubstancesfromtheir
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surroundings. Theremainingoptions arenot inclusive in their descriptions of cellular
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metabolicabsorption.
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PTS: i . u i . u 1 DIF: CognitiveLevel:Remembering i.u i.u
2. Whereismostofacell’sgeneticinformation,includingRNAandDNA,contained? i.u i.u i.u i.u i.u i.u i.u i.u i.u i.u i.u
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C i . u
Thenucleuscontainsthenucleolus,asmalldensestructurecomposedlargelyofRNA,mostoft he cellular
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DNA,andtheDNA-bindingproteins,suchasthehistones,whichregulateitsactivity.
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The mitochondria are responsible for cellular respiration and energyproduction.
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i Ribosomes’chieffunctionistoprovidesitesforcellularproteinsynthesis.Lysosomesfunctionas
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the intracellulardigestive system.
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PTS: i . u i . u 1 DIF: CognitiveLevel: Remembering i.u i.u
3. Whichcomponentofthecellproduceshydrogenperoxide(H2O2)byusingoxygento i.u i.u i.u i.u i.u i.u i.u i.u i.u i.u i.u
i.u removehydrogen atoms from specificsubstrates in an oxidative reaction? i.u i.u i.u i.u i.u i.u i.u i.u
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B i . u