TEST BANK
Pharmacology Illustrated Reviews 7th Edition Whalen Test Bank
.
TABLE OF CONTENT
Chapter 1: Pharmacokinetics
Chapter 2: Drug–Receptor Interactions and Pharmacodynamics
Chapter 3: The Autonomic Nervous System
Chapter 4: Cholinergic Agonists
Chapter 5: Cholinergic Antagonists
Pharmacology Illustrated Reviews Chapter 6: Adrenergic Agonists
Chapter 7: Adrenergic Antagonists
Chapter 8: Drugs for Neurodegenerative Diseases
Chapter 9: Anxiolytic and Hypnotic Drugs
7th Edition Whalen Test Bank Chapter 10: Antidepressants
Chapter 11: Antipsychotic Drugs
Chapter 12: Drugs for Epilepsy
Chapter 13: Anesthetics
Chapter 14: Opioids
Chapter 15: Drugs of Abuse
Chapter 16: CNS Stimulants
Chapter 17: Antihypertensives
Chapter 18: Diuretics
Chapter 19: Heart Failure
Chapter 20: Antiarrhythmics
Chapter 21: Antianginal Drugs
Chapter 22: Anticoagulants and Antiplatelet Agents
Chapter 23: Drugs for Hyperlipidemia
Chapter 24: Pituitary and Thyroid
Chapter 25: Drugs for Diabetes
Chapter 26: Estrogens and Androgens
Chapter 27: Adrenal Hormones
Chapter 28: Drugs for Obesity
Chapter 29: Drugs for Disorders of the Respiratory System
Chapter 30: Antihistamines
Chapter 31: Gastrointestinal and Antiemetic Drugs
Chapter 32: Drugs for Urologic Disorders
Chapter 33: Drugs for Anemia
Chapter 34: Drugs for Dermatologic Disorders
Chapter 35: Drugs for Bone Disorders
Chapter 36: Anti-inflammatory, Antipyretic, and Analgesic Agents
Chapter 37: Principles of Antimicrobial Therapy
Chapter 38: Cell Wall Inhibitors
Chapter 39: Protein Synthesis Inhibitors
Chapter 40: Quinolones, Folic Acid Antagonists, and Urinary Tract Antiseptics
Chapter 41: Antimycobacterial Drugs
Chapter 42: Antifungal Drugs
Chapter 43: Antiprotozoal Drugs
TEST BANK
Chapter 44: Anthelmintic Drugs
Chapter 45: Antiviral Drugs
Chapter 46: Anticancer Drugs
Chapter 47: Immunosuppressants
Chapter 48: Clinical Toxicology
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Material
Page 1 of 507
Pharmacology Illustrated Reviews 7th Edition Whalen 3. The nurse is teaching a patient who will be discharged home with a prescription for an enteric-
coated tablet. Which statement by the patient indicates understanding of the teaching?
Test Bank
a. I may crush the tablet and put it in applesauce to improve absorption.
Chapter 1: Pharmacokinetics b. I should consume acidic foods to enhance absorption of this medication.
c. I should expect a delay in onset of the drugs effects after taking the tablet.
MULTIPLE CHOICE
d. I should take this medication with high-fat foods to improve its action.
ANS: C
1. Which drugs will go through a pharmaceutic phase after it is administered?
Enteric-coated tablets resist disintegration in the acidic environment of the stomach and
a. Intramuscular cephalosporins
disintegrate when they reach the small intestine. There is usually some delay in onset of actions
b. Intravenous vasopressors
after taking these medications. Enteric-coated tablets should not be crushed or chewed, which
c. Oral analgesics
would alter the time and location of absorption. Acidic foods will not enhance the absorption of
d. Subcutaneous antiglycemics
the medication. The patient should not to eat high-fat food before ingesting an enteric-coated
ANS: C
tablet, because high-fat foods decrease the absorption rate.
When drugs are administered parenterally, there is no pharmaceutic phase, which occurs when a
drug becomes a solution that can cross the biologic membrane.
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 3
TOP: NURSING PROCESS: Nursing Intervention
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: NURSING PROCESS: Assessment
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
4. A patient who is newly diagnosed with type 1 diabetes mellitus asks why insulin must be
given by subcutaneous injection instead of by mouth. The nurse will explain that this is because
2. The nurse is preparing to administer an oral medication and wants to ensure a rapid drug
a. absorption is diminished by the first-pass effects in the liver.
action. Which form of the medication will the nurse administer?
b. absorption is faster when insulin is given subcutaneously.
a. Capsule
c. digestive enzymes in the gastrointestinal tract prevent absorption.
b. Enteric-coated pill
d. the oral form is less predictable with more adverse effects.
c. Liquid suspension
ANS: C
d. Tablet
Insulin, growth hormones, and other protein-based drugs are destroyed in the small intestine by
ANS: C
digestive enzymes and must be given parenterally. Because insulin is destroyed by digestive
Liquid drugs are already in solution, which is the form necessary for absorption in the GI tract.
enzymes, it would not make it to the liver for metabolism with a first-pass effect. Subcutaneous
The other forms must disintegrate into small particles and then dissolve before being
tissue has fewer blood vessels, so absorption is slower in such tissue. Insulin is given
absorbed.
subcutaneously because it is desirable to have it absorb slowly.
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
TOP: NURSING PROCESS: Nursing Intervention
TOP: NURSING PROCESS: Nursing Intervention: Patient Teaching
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
Page 1 of 507 Page 2 of 507
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Material Material
5. The nurse is preparing to administer an oral medication that is water-soluble. The nurse Drugs given IM are absorbed faster in muscles that have more blood vessels, such as the deltoid,
understands that this drug rather than those with fewer blood vessels, such as the gluteals. Subcutaneous routes are used
a. must be taken on an empty stomach. when absorption needs to be slower and more sustained.
b. requires active transport for absorption.
c. should be taken with fatty foods. DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 4
d. will readily diffuse into the gastrointestinal tract. TOP: NURSING PROCESS: Planning
ANS: B MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
Water-soluble drugs require a carrier enzyme or protein to pass through the GI membrane.
8. The nurse is reviewing medication information with a nursing student prior to administering
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4 an oral drug and notes that the drug has extensive first-pass effects. Which statement by the
TOP: NURSING PROCESS: Nursing Intervention student indicates a need for further teaching about this medication?
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies a. The first-pass effect means the drug may be absorbed into systemic circulation from the
intestinal lumen.
6. A nurse is preparing to administer an oral drug that is best absorbed in an acidic environment. b. The first-pass effect means the drug may be changed to an inactive form and excreted.
How will the nurse give the drug? c. The first-pass effect means the drug may be changed to a metabolite, which may be more
a. On an empty stomach active than the original.
b. With a full glass of water d. The first-pass effect means the drug may be unchanged as it passes through the liver.
c. With food ANS: A
d. With high-fat food Drugs that undergo first-pass metabolism are absorbed into the portal vein from the intestinal
ANS: C lumen and go through the liver where they are either unchanged or are metabolized to an inactive
Food can stimulate the production of gastric acid so medications requiring an acidic environment or a more active form.
should be given with a meal. High-fat foods are useful for drugs that are lipid soluble.
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 4 TOP: NURSING PROCESS: Nursing Intervention
TOP: NURSING PROCESS: Nursing Intervention MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
9. The nurse prepares to change a patients medication from an intravenous to an oral form and
7. The nurse is preparing an injectable drug and wants to administer it for rapid absorption. How notes that the oral form is ordered in a higher dose. The nurse understands that this is due to
will the nurse give this medication? differences in
a. IM into the deltoid muscle a. bioavailability.
b. IM into the gluteal muscle b. pinocytosis.
c. SubQ into abdominal tissue c. protein binding.
d. SubQ into the upper arm d. tachyphylaxis.
ANS: A ANS: A
Page 3 of 507 Page 4 of 507
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Material Material
Oral drugs may have less bioavailability because a lower percentage of the drug reaches the free drug in circulation and an increased risk of adverse effects as well as increased
systemic circulation. Pinocytosis refers to the process by which cells carry a solute across a bioavailability, increased drug effects, and increased drug interactions.
membrane. Protein binding can occur with both routes. Tachyphylaxis describes a rapid decrease
in response to drugs that occurs when tolerance develops quickly. DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 5
TOP: NURSING PROCESS: Evaluation
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4 MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: NURSING PROCESS: Assessment
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies 12. A patient has been taking a drug that has a protein-binding effect of 75%. The provider adds
a new medication that has a protein-binding effect of 90%. The nurse will expect
10. The nurse is preparing to administer a drug and learns that it binds to protein at a rate of 90%. a. decreased drug effects of the first drug.
The patients serum albumin level is low. The nurse will observe the patient for b. decreased therapeutic range of the first drug.
a. decreased drug absorption. c. increased drug effects of the first drug.
b. decreased drug interactions. d. increased therapeutic range of the first drug.
c. decreased drug toxicity. ANS: C
d. increased drug effects. Adding another highly protein-bound drug will displace the first drug from protein-binding sites
ANS: D and release more free drug increasing the drugs effects. This does not alter the therapeutic range,
Drugs that are highly protein-bound bind with albumin and other proteins, leaving less free drug which is the serum level between drug effectiveness and toxicity.
in circulation. If a patient has a low albumin, the drug is not bound, and there is more free drug
to cause drug effects. There would be increased absorption, increased interactions with other DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 5
drugs, and increased toxicity. TOP: NURSING PROCESS: Nursing Intervention/Evaluation
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 5
TOP: NURSING PROCESS: Evaluation 13. The nurse gives a medication to a patient with a history of liver disease. The nurse will
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies monitor this patient for
a. decreased drug effects.
11. The nurse is administering two drugs to a patient and learns that both drugs are highly b. increased drug effects.
protein-bound. The nurse may expect c. decreased therapeutic range.
a. decreased bioavailability of both drugs. d. increased therapeutic range.
b. decreased drug effects. ANS: B
c. decreased drug interactions. Liver diseases such as cirrhosis and hepatitis alter drug metabolism by inhibiting the drug-
d. increased risk of adverse effects. metabolizing enzymes in the liver. When the drug metabolism rate is decreased, excess drug
ANS: D accumulation can occur and lead to toxicity.
Two drugs that are highly protein-bound will compete for protein-binding sites, leaving more
Page 5 of 507 Page 6 of 507
Pharmacology Illustrated Reviews 7th Edition Whalen Test Bank
.
TABLE OF CONTENT
Chapter 1: Pharmacokinetics
Chapter 2: Drug–Receptor Interactions and Pharmacodynamics
Chapter 3: The Autonomic Nervous System
Chapter 4: Cholinergic Agonists
Chapter 5: Cholinergic Antagonists
Pharmacology Illustrated Reviews Chapter 6: Adrenergic Agonists
Chapter 7: Adrenergic Antagonists
Chapter 8: Drugs for Neurodegenerative Diseases
Chapter 9: Anxiolytic and Hypnotic Drugs
7th Edition Whalen Test Bank Chapter 10: Antidepressants
Chapter 11: Antipsychotic Drugs
Chapter 12: Drugs for Epilepsy
Chapter 13: Anesthetics
Chapter 14: Opioids
Chapter 15: Drugs of Abuse
Chapter 16: CNS Stimulants
Chapter 17: Antihypertensives
Chapter 18: Diuretics
Chapter 19: Heart Failure
Chapter 20: Antiarrhythmics
Chapter 21: Antianginal Drugs
Chapter 22: Anticoagulants and Antiplatelet Agents
Chapter 23: Drugs for Hyperlipidemia
Chapter 24: Pituitary and Thyroid
Chapter 25: Drugs for Diabetes
Chapter 26: Estrogens and Androgens
Chapter 27: Adrenal Hormones
Chapter 28: Drugs for Obesity
Chapter 29: Drugs for Disorders of the Respiratory System
Chapter 30: Antihistamines
Chapter 31: Gastrointestinal and Antiemetic Drugs
Chapter 32: Drugs for Urologic Disorders
Chapter 33: Drugs for Anemia
Chapter 34: Drugs for Dermatologic Disorders
Chapter 35: Drugs for Bone Disorders
Chapter 36: Anti-inflammatory, Antipyretic, and Analgesic Agents
Chapter 37: Principles of Antimicrobial Therapy
Chapter 38: Cell Wall Inhibitors
Chapter 39: Protein Synthesis Inhibitors
Chapter 40: Quinolones, Folic Acid Antagonists, and Urinary Tract Antiseptics
Chapter 41: Antimycobacterial Drugs
Chapter 42: Antifungal Drugs
Chapter 43: Antiprotozoal Drugs
TEST BANK
Chapter 44: Anthelmintic Drugs
Chapter 45: Antiviral Drugs
Chapter 46: Anticancer Drugs
Chapter 47: Immunosuppressants
Chapter 48: Clinical Toxicology
, Stuvia.com - The Marketplace to Buy and Sell your Study
Material
Page 1 of 507
Pharmacology Illustrated Reviews 7th Edition Whalen 3. The nurse is teaching a patient who will be discharged home with a prescription for an enteric-
coated tablet. Which statement by the patient indicates understanding of the teaching?
Test Bank
a. I may crush the tablet and put it in applesauce to improve absorption.
Chapter 1: Pharmacokinetics b. I should consume acidic foods to enhance absorption of this medication.
c. I should expect a delay in onset of the drugs effects after taking the tablet.
MULTIPLE CHOICE
d. I should take this medication with high-fat foods to improve its action.
ANS: C
1. Which drugs will go through a pharmaceutic phase after it is administered?
Enteric-coated tablets resist disintegration in the acidic environment of the stomach and
a. Intramuscular cephalosporins
disintegrate when they reach the small intestine. There is usually some delay in onset of actions
b. Intravenous vasopressors
after taking these medications. Enteric-coated tablets should not be crushed or chewed, which
c. Oral analgesics
would alter the time and location of absorption. Acidic foods will not enhance the absorption of
d. Subcutaneous antiglycemics
the medication. The patient should not to eat high-fat food before ingesting an enteric-coated
ANS: C
tablet, because high-fat foods decrease the absorption rate.
When drugs are administered parenterally, there is no pharmaceutic phase, which occurs when a
drug becomes a solution that can cross the biologic membrane.
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 3
TOP: NURSING PROCESS: Nursing Intervention
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: NURSING PROCESS: Assessment
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
4. A patient who is newly diagnosed with type 1 diabetes mellitus asks why insulin must be
given by subcutaneous injection instead of by mouth. The nurse will explain that this is because
2. The nurse is preparing to administer an oral medication and wants to ensure a rapid drug
a. absorption is diminished by the first-pass effects in the liver.
action. Which form of the medication will the nurse administer?
b. absorption is faster when insulin is given subcutaneously.
a. Capsule
c. digestive enzymes in the gastrointestinal tract prevent absorption.
b. Enteric-coated pill
d. the oral form is less predictable with more adverse effects.
c. Liquid suspension
ANS: C
d. Tablet
Insulin, growth hormones, and other protein-based drugs are destroyed in the small intestine by
ANS: C
digestive enzymes and must be given parenterally. Because insulin is destroyed by digestive
Liquid drugs are already in solution, which is the form necessary for absorption in the GI tract.
enzymes, it would not make it to the liver for metabolism with a first-pass effect. Subcutaneous
The other forms must disintegrate into small particles and then dissolve before being
tissue has fewer blood vessels, so absorption is slower in such tissue. Insulin is given
absorbed.
subcutaneously because it is desirable to have it absorb slowly.
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
TOP: NURSING PROCESS: Nursing Intervention
TOP: NURSING PROCESS: Nursing Intervention: Patient Teaching
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
Page 1 of 507 Page 2 of 507
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Material Material
5. The nurse is preparing to administer an oral medication that is water-soluble. The nurse Drugs given IM are absorbed faster in muscles that have more blood vessels, such as the deltoid,
understands that this drug rather than those with fewer blood vessels, such as the gluteals. Subcutaneous routes are used
a. must be taken on an empty stomach. when absorption needs to be slower and more sustained.
b. requires active transport for absorption.
c. should be taken with fatty foods. DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 4
d. will readily diffuse into the gastrointestinal tract. TOP: NURSING PROCESS: Planning
ANS: B MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
Water-soluble drugs require a carrier enzyme or protein to pass through the GI membrane.
8. The nurse is reviewing medication information with a nursing student prior to administering
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4 an oral drug and notes that the drug has extensive first-pass effects. Which statement by the
TOP: NURSING PROCESS: Nursing Intervention student indicates a need for further teaching about this medication?
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies a. The first-pass effect means the drug may be absorbed into systemic circulation from the
intestinal lumen.
6. A nurse is preparing to administer an oral drug that is best absorbed in an acidic environment. b. The first-pass effect means the drug may be changed to an inactive form and excreted.
How will the nurse give the drug? c. The first-pass effect means the drug may be changed to a metabolite, which may be more
a. On an empty stomach active than the original.
b. With a full glass of water d. The first-pass effect means the drug may be unchanged as it passes through the liver.
c. With food ANS: A
d. With high-fat food Drugs that undergo first-pass metabolism are absorbed into the portal vein from the intestinal
ANS: C lumen and go through the liver where they are either unchanged or are metabolized to an inactive
Food can stimulate the production of gastric acid so medications requiring an acidic environment or a more active form.
should be given with a meal. High-fat foods are useful for drugs that are lipid soluble.
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 4 TOP: NURSING PROCESS: Nursing Intervention
TOP: NURSING PROCESS: Nursing Intervention MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
9. The nurse prepares to change a patients medication from an intravenous to an oral form and
7. The nurse is preparing an injectable drug and wants to administer it for rapid absorption. How notes that the oral form is ordered in a higher dose. The nurse understands that this is due to
will the nurse give this medication? differences in
a. IM into the deltoid muscle a. bioavailability.
b. IM into the gluteal muscle b. pinocytosis.
c. SubQ into abdominal tissue c. protein binding.
d. SubQ into the upper arm d. tachyphylaxis.
ANS: A ANS: A
Page 3 of 507 Page 4 of 507
, Stuvia.com - The Marketplace to Buy and Sell your Study Stuvia.com - The Marketplace to Buy and Sell your Study
Material Material
Oral drugs may have less bioavailability because a lower percentage of the drug reaches the free drug in circulation and an increased risk of adverse effects as well as increased
systemic circulation. Pinocytosis refers to the process by which cells carry a solute across a bioavailability, increased drug effects, and increased drug interactions.
membrane. Protein binding can occur with both routes. Tachyphylaxis describes a rapid decrease
in response to drugs that occurs when tolerance develops quickly. DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 5
TOP: NURSING PROCESS: Evaluation
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4 MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: NURSING PROCESS: Assessment
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies 12. A patient has been taking a drug that has a protein-binding effect of 75%. The provider adds
a new medication that has a protein-binding effect of 90%. The nurse will expect
10. The nurse is preparing to administer a drug and learns that it binds to protein at a rate of 90%. a. decreased drug effects of the first drug.
The patients serum albumin level is low. The nurse will observe the patient for b. decreased therapeutic range of the first drug.
a. decreased drug absorption. c. increased drug effects of the first drug.
b. decreased drug interactions. d. increased therapeutic range of the first drug.
c. decreased drug toxicity. ANS: C
d. increased drug effects. Adding another highly protein-bound drug will displace the first drug from protein-binding sites
ANS: D and release more free drug increasing the drugs effects. This does not alter the therapeutic range,
Drugs that are highly protein-bound bind with albumin and other proteins, leaving less free drug which is the serum level between drug effectiveness and toxicity.
in circulation. If a patient has a low albumin, the drug is not bound, and there is more free drug
to cause drug effects. There would be increased absorption, increased interactions with other DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 5
drugs, and increased toxicity. TOP: NURSING PROCESS: Nursing Intervention/Evaluation
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 5
TOP: NURSING PROCESS: Evaluation 13. The nurse gives a medication to a patient with a history of liver disease. The nurse will
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies monitor this patient for
a. decreased drug effects.
11. The nurse is administering two drugs to a patient and learns that both drugs are highly b. increased drug effects.
protein-bound. The nurse may expect c. decreased therapeutic range.
a. decreased bioavailability of both drugs. d. increased therapeutic range.
b. decreased drug effects. ANS: B
c. decreased drug interactions. Liver diseases such as cirrhosis and hepatitis alter drug metabolism by inhibiting the drug-
d. increased risk of adverse effects. metabolizing enzymes in the liver. When the drug metabolism rate is decreased, excess drug
ANS: D accumulation can occur and lead to toxicity.
Two drugs that are highly protein-bound will compete for protein-binding sites, leaving more
Page 5 of 507 Page 6 of 507
