Test bank for Tietz Fundamentals of Clinical Chemistry
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
UJ UJ UJ UJ UJ UJ UJ UJ
U J
UJ UJ
Table of contents: UJ UJ
I. Principles Of Laboratory Medicine
UJ UJ UJ UJ
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 3. Clinical Evaluation of Methods
UJ UJ UJ UJ UJ
Chapter 4. Evidence-Based Laboratory Medicine
UJ UJ UJ UJ
Chapter 5. Establishment and Use of Reference Values
UJ UJ UJ UJ UJ UJ UJ
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 7. Quality ManagementUJ UJ UJ
II. Analytical Techniques And Instrumentation
UJ UJ UJ UJ
Chapter 8. Principles of Basic Techniques and Laboratory Safety
UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 9. Optical TechniquesUJ UJ UJ
Chapter 10. Electrochemistry and Chemical Sensors
UJ UJ UJ UJ UJ
Chapter 11. Electrophoresis UJ UJ
Chapter 12. Chromatography UJ UJ
Chapter 13. Mass SpectrometryUJ UJ UJ
Chapter 14. Enzyme and Rate Analyses
UJ UJ UJ UJ UJ
Chapter 15. Immunochemical Techniques
UJ UJ UJ
Chapter 16 Automation UJ UJ
Chapter 17. Point-of-Care Instrumentation
UJ UJ UJ
III. Analytes
U J
Chapter 18. Amino Acids, Peptides, and Proteins
UJ UJ UJ UJ UJ UJ
Chapter 19. Serum Enzymes UJ UJ UJ
Chapter 20. Tumor Markers and Cancer Genes
UJ UJ UJ UJ UJ UJ
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 22. Carbohydrates UJ UJ
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
UJ UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 24. Electrolytes and Blood Gases
UJ UJ UJ UJ UJ
Chapter 25. Hormones UJ UJ
Chapter 26. Catecholamines and Serotonin
UJ U J UJ UJ
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
UJ U J UJ UJ UJ UJ
Chapter 28. Hemoglobin, Iron, and Bilirubin
UJ UJ UJ UJ UJ
Chapter 29. Porphyrins and Porphyrias
UJ UJ UJ UJ
Chapter 30. Therapeutic Drugs and Their Management
UJ UJ UJ UJ UJ UJ
Chapter 31. Clinical Toxicology
UJ UJ UJ
Chapter 32. Toxic Metals UJ U J UJ
IV. Pathophysiology
U J
Chapter 33. Diabetes UJ UJ
,Chapter 34. Cardiovascular Disease
UJ U J UJ
Chapter 35. Kidney Disease
UJ UJ UJ
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
UJ U J UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 37. Liver Disease
UJ UJUJ UJ
Chapter 38. Gastrointestinal and Pancreatic Diseases
UJ U J UJ UJ UJ
Chapter 39. Disorders of Bone and Mineral Metabolism
UJ UJUJ UJ UJ UJ UJ UJ
Chapter 40. Disorders of the Pituitary Gland
UJ UJUJ UJ UJ UJ UJ
Chapter 41. Disorders of the Adrenal Cortex
UJ U J UJ UJ UJ UJ
Chapter 42. Thyroid Disorders
UJ U J UJ
Chapter 43. Reproduction-Related Disorders
UJ U J UJ
Chapter 44. Pregnancy and Prenatal Testing
UJ UJUJ UJ UJ UJ
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
UJ U J UJ UJ UJ UJ UJ UJ
Chapter 46. Pharmacogenetics
UJ UJ
V. Molecular Diagnostics
U J UJ
Chapter 47. Principles of Molecular Biology
UJ UJ UJ UJ UJ
Chapter 48. Nucleic Acid Techniques and Applications
UJ UJ UJ UJ UJ UJ
Chapter 49. Genomes and Nucleic Acid Alterations
UJ UJ UJ UJ UJ UJ
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
MULTIPLE CHOICE UJ
1. An individual working in a clinical chemistry laboratory is married to a sales representative w
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
ho works for a company that sells chemistry laboratory supplies. When the laboratory manag
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
er requests a list of needed supplies, cost of supplies, and vendors, this individual onlyrecom
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
mends the spouse’s company as the vendor. This is considered to be a(n):
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
a. accounting issue. UJ
b. possible conflict of interest. UJ UJ UJ
c. maintenance of confidentiality issue. UJ UJ UJ
d. problem with resource allocation. UJ UJ UJ
ANS: B U J
Concern has been raised over the interrelationships between practitioners in the medical field
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturer
UJ UJ UJ UJ UJ UJ UJ UJ UJ
s and providers of diagnostic equipment and supplies. These concerns led the National Institut
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
es of Health (NIH) in 1995 to require official institutional review of financial disclosure by resear
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
chers and management of situations in which disclosure indicates potentialconflicts of interest.
UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J UJ UJ
DIF: 1 REF: Page 4-5 UJUJU J UJ OBJ: 6 | 7 U J UJ UJ
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce t
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
he pain following her recent surgery. A friend of the patient claims that the same painkiller“
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
worked wonders” to reduce her pain after the same surgery. The physician states that the di
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
fference in the effect of the drug might be caused by UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
, which is studied in pharmacogenetics.
UJ UJ UJ UJ UJ
a. epidemiology
b. an inherited disease UJ UJ
c. a conflict of interest UJ UJ UJ
d. a genetic variation in drug-metabolizing enzymes
UJ UJ UJ UJ UJ
ANS: D U J
Pharmacogenetics is the study of the genetic variation of drug metabolism between UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
individuals.
DIF: 1 REF: Page 3 UJUJU J UJ OBJ: 1 U J
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the n
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
ame of a close friend printed on the bar-
UJ UJ UJ UJ UJ UJ UJ UJ
coded label. The genetic test that is ordered on thefriend’s sample would provide diagnostic
UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J UJ UJ UJ UJ U
information about a disorder that has a poor prognosis, and the test is usually performed by
J UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
John. He asks a fellow employee to analyzethe sample for him and not divulge the results. T
UJ UJ UJ UJ UJ UJ UJ UJ U
J UJ UJ UJ UJ UJ UJ UJ UJ UJ
his ethical issue concerns:
UJ UJ UJ
a. confidentiality of patient genetic and medical information. UJ UJ UJ UJ UJ UJ
b. a conflict of interest. UJ UJ UJ
c. resource allocation. UJ
d. diagnostic accuracy. UJ
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
UJ UJ UJ UJ UJ UJ UJ UJ
U J
UJ UJ
Table of contents: UJ UJ
I. Principles Of Laboratory Medicine
UJ UJ UJ UJ
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 3. Clinical Evaluation of Methods
UJ UJ UJ UJ UJ
Chapter 4. Evidence-Based Laboratory Medicine
UJ UJ UJ UJ
Chapter 5. Establishment and Use of Reference Values
UJ UJ UJ UJ UJ UJ UJ
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 7. Quality ManagementUJ UJ UJ
II. Analytical Techniques And Instrumentation
UJ UJ UJ UJ
Chapter 8. Principles of Basic Techniques and Laboratory Safety
UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 9. Optical TechniquesUJ UJ UJ
Chapter 10. Electrochemistry and Chemical Sensors
UJ UJ UJ UJ UJ
Chapter 11. Electrophoresis UJ UJ
Chapter 12. Chromatography UJ UJ
Chapter 13. Mass SpectrometryUJ UJ UJ
Chapter 14. Enzyme and Rate Analyses
UJ UJ UJ UJ UJ
Chapter 15. Immunochemical Techniques
UJ UJ UJ
Chapter 16 Automation UJ UJ
Chapter 17. Point-of-Care Instrumentation
UJ UJ UJ
III. Analytes
U J
Chapter 18. Amino Acids, Peptides, and Proteins
UJ UJ UJ UJ UJ UJ
Chapter 19. Serum Enzymes UJ UJ UJ
Chapter 20. Tumor Markers and Cancer Genes
UJ UJ UJ UJ UJ UJ
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 22. Carbohydrates UJ UJ
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
UJ UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 24. Electrolytes and Blood Gases
UJ UJ UJ UJ UJ
Chapter 25. Hormones UJ UJ
Chapter 26. Catecholamines and Serotonin
UJ U J UJ UJ
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
UJ U J UJ UJ UJ UJ
Chapter 28. Hemoglobin, Iron, and Bilirubin
UJ UJ UJ UJ UJ
Chapter 29. Porphyrins and Porphyrias
UJ UJ UJ UJ
Chapter 30. Therapeutic Drugs and Their Management
UJ UJ UJ UJ UJ UJ
Chapter 31. Clinical Toxicology
UJ UJ UJ
Chapter 32. Toxic Metals UJ U J UJ
IV. Pathophysiology
U J
Chapter 33. Diabetes UJ UJ
,Chapter 34. Cardiovascular Disease
UJ U J UJ
Chapter 35. Kidney Disease
UJ UJ UJ
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
UJ U J UJ UJ UJ UJ UJ UJ UJ UJ
Chapter 37. Liver Disease
UJ UJUJ UJ
Chapter 38. Gastrointestinal and Pancreatic Diseases
UJ U J UJ UJ UJ
Chapter 39. Disorders of Bone and Mineral Metabolism
UJ UJUJ UJ UJ UJ UJ UJ
Chapter 40. Disorders of the Pituitary Gland
UJ UJUJ UJ UJ UJ UJ
Chapter 41. Disorders of the Adrenal Cortex
UJ U J UJ UJ UJ UJ
Chapter 42. Thyroid Disorders
UJ U J UJ
Chapter 43. Reproduction-Related Disorders
UJ U J UJ
Chapter 44. Pregnancy and Prenatal Testing
UJ UJUJ UJ UJ UJ
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
UJ U J UJ UJ UJ UJ UJ UJ
Chapter 46. Pharmacogenetics
UJ UJ
V. Molecular Diagnostics
U J UJ
Chapter 47. Principles of Molecular Biology
UJ UJ UJ UJ UJ
Chapter 48. Nucleic Acid Techniques and Applications
UJ UJ UJ UJ UJ UJ
Chapter 49. Genomes and Nucleic Acid Alterations
UJ UJ UJ UJ UJ UJ
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
MULTIPLE CHOICE UJ
1. An individual working in a clinical chemistry laboratory is married to a sales representative w
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
ho works for a company that sells chemistry laboratory supplies. When the laboratory manag
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
er requests a list of needed supplies, cost of supplies, and vendors, this individual onlyrecom
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
mends the spouse’s company as the vendor. This is considered to be a(n):
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
a. accounting issue. UJ
b. possible conflict of interest. UJ UJ UJ
c. maintenance of confidentiality issue. UJ UJ UJ
d. problem with resource allocation. UJ UJ UJ
ANS: B U J
Concern has been raised over the interrelationships between practitioners in the medical field
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturer
UJ UJ UJ UJ UJ UJ UJ UJ UJ
s and providers of diagnostic equipment and supplies. These concerns led the National Institut
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
es of Health (NIH) in 1995 to require official institutional review of financial disclosure by resear
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
chers and management of situations in which disclosure indicates potentialconflicts of interest.
UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J UJ UJ
DIF: 1 REF: Page 4-5 UJUJU J UJ OBJ: 6 | 7 U J UJ UJ
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce t
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
he pain following her recent surgery. A friend of the patient claims that the same painkiller“
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
worked wonders” to reduce her pain after the same surgery. The physician states that the di
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
fference in the effect of the drug might be caused by UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
, which is studied in pharmacogenetics.
UJ UJ UJ UJ UJ
a. epidemiology
b. an inherited disease UJ UJ
c. a conflict of interest UJ UJ UJ
d. a genetic variation in drug-metabolizing enzymes
UJ UJ UJ UJ UJ
ANS: D U J
Pharmacogenetics is the study of the genetic variation of drug metabolism between UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J
individuals.
DIF: 1 REF: Page 3 UJUJU J UJ OBJ: 1 U J
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the n
UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
ame of a close friend printed on the bar-
UJ UJ UJ UJ UJ UJ UJ UJ
coded label. The genetic test that is ordered on thefriend’s sample would provide diagnostic
UJ UJ UJ UJ UJ UJ UJ UJ UJ U
J UJ UJ UJ UJ U
information about a disorder that has a poor prognosis, and the test is usually performed by
J UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ
John. He asks a fellow employee to analyzethe sample for him and not divulge the results. T
UJ UJ UJ UJ UJ UJ UJ UJ U
J UJ UJ UJ UJ UJ UJ UJ UJ UJ
his ethical issue concerns:
UJ UJ UJ
a. confidentiality of patient genetic and medical information. UJ UJ UJ UJ UJ UJ
b. a conflict of interest. UJ UJ UJ
c. resource allocation. UJ
d. diagnostic accuracy. UJ
