1
MLS HEMATOLOGY EXAM /HEMATOLOGY MLS
ACTUAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES (VERIFIED
ANSWERS) |ALREADY GRADED A+
What is the first type of cell produced by the developing embryo? -
(answer)Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat?
- (answer)50%
Which of the following is not characteristic of pluripotent hematopoietic stem
cells? - (answer)Express the stem marker CD13
In an adult, what are the two best areas for obtaining active bone marrow by
aspiration? - (answer)Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow
(M:E ratio)? - (answer)4:1
Which of the following does not accurately describe hematopoietic growth
factors? - (answer)Action of majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis? -
(answer)Liver
The mechanism that relays information about tissue oxygen levels to
erythropoietin-producing sites is located in the: - (answer)Kidney
, 2
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located
in the: - (answer)Thymus and bone marrow
Programmed cell death is called: - (answer)Apoptosis
In what area of the bone marrow does hematopoiesis take place? -
(answer)Cords
Bone marrow cellularity refers to the ration of: - (answer)Hematopoietic tissue
to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by: -
(answer)Monocytes and T lymphocytes
What is the approximate total blood volume in an adult? - (answer)6 L
The myeloid progenitor cell can produce cells committed to: -
(answer)Granulocytic, erythrocytic, monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: -
(answer)Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered
abnormal? - (answer)The presence of 10% myeloblasts on the cell differential
count
As most blood cell lines mature, which of the following is characteristic? -
(answer)Nucleus to cytoplasm ratio (N:C) decreases
, 3
Which of the following describes thrombopoietin (TPO)? - (answer)Hormone
produced by the liver that stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis
can be termed: - (answer)Myeloid metaplasia or extramedullary
What is the average life span of a normal red blood cell? - (answer)120 days
The Na+-K+ cation pump is an important mechanism in keeping the red blood
cell intact. Its function is to maintain a high level of: - (answer)Intracellular K+
Which of the following depicts the structure of the hemoglobin molecule? -
(answer)Four heme groups, four globin chains
Which of the following describes the process known as culling? -
(answer)Removal of abnormal red cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: -
(answer)Carboxyhemoglobin and methemoglobin
The majority of iron found in an adult is a constituent of: -
(answer)Hemoglobin
A senescent red blood cell is one that has: - (answer)Lived its life span
What red cell morphologic abnormality is described by the term
"poikilocytosis"? - (answer)Deviations from normal shape
Howell-Jolly bodies are composed of: - (answer)DNA
, 4
When spherocytes are reported, what is observed on the peripheral blood
smear? - (answer)Red cells without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse granules
composed of __________ that are reported as _________. -
(answer)Aggregated ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear is
characteristic of: - (answer)Multiple myeloma
Which of the following is most frequently associated with the inclusion bodies
seen in Color Plate 1? - (answer)Post-splenectomy
Which of the following statements about iron absorption is true? -
(answer)Absorption increases when erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules or
deposits? - (answer)Siderocyte
Which of the following is associated with a "shift to the left" in the oxygen
dissociation curve of hemoglobin? - (answer)Decreased oxygen release
Which of the following statements does not characterize erythropoietin (EPO)?
- (answer)Decreases stimulation of erythropoiesis when cellular hypoxia
increases
Which of the following factors will result in an immediate increase in oxygen
delivery to the tissues? - (answer)Increased hemoglobin binding of 2,3-BPG
MLS HEMATOLOGY EXAM /HEMATOLOGY MLS
ACTUAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES (VERIFIED
ANSWERS) |ALREADY GRADED A+
What is the first type of cell produced by the developing embryo? -
(answer)Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat?
- (answer)50%
Which of the following is not characteristic of pluripotent hematopoietic stem
cells? - (answer)Express the stem marker CD13
In an adult, what are the two best areas for obtaining active bone marrow by
aspiration? - (answer)Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow
(M:E ratio)? - (answer)4:1
Which of the following does not accurately describe hematopoietic growth
factors? - (answer)Action of majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis? -
(answer)Liver
The mechanism that relays information about tissue oxygen levels to
erythropoietin-producing sites is located in the: - (answer)Kidney
, 2
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located
in the: - (answer)Thymus and bone marrow
Programmed cell death is called: - (answer)Apoptosis
In what area of the bone marrow does hematopoiesis take place? -
(answer)Cords
Bone marrow cellularity refers to the ration of: - (answer)Hematopoietic tissue
to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by: -
(answer)Monocytes and T lymphocytes
What is the approximate total blood volume in an adult? - (answer)6 L
The myeloid progenitor cell can produce cells committed to: -
(answer)Granulocytic, erythrocytic, monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: -
(answer)Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered
abnormal? - (answer)The presence of 10% myeloblasts on the cell differential
count
As most blood cell lines mature, which of the following is characteristic? -
(answer)Nucleus to cytoplasm ratio (N:C) decreases
, 3
Which of the following describes thrombopoietin (TPO)? - (answer)Hormone
produced by the liver that stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis
can be termed: - (answer)Myeloid metaplasia or extramedullary
What is the average life span of a normal red blood cell? - (answer)120 days
The Na+-K+ cation pump is an important mechanism in keeping the red blood
cell intact. Its function is to maintain a high level of: - (answer)Intracellular K+
Which of the following depicts the structure of the hemoglobin molecule? -
(answer)Four heme groups, four globin chains
Which of the following describes the process known as culling? -
(answer)Removal of abnormal red cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: -
(answer)Carboxyhemoglobin and methemoglobin
The majority of iron found in an adult is a constituent of: -
(answer)Hemoglobin
A senescent red blood cell is one that has: - (answer)Lived its life span
What red cell morphologic abnormality is described by the term
"poikilocytosis"? - (answer)Deviations from normal shape
Howell-Jolly bodies are composed of: - (answer)DNA
, 4
When spherocytes are reported, what is observed on the peripheral blood
smear? - (answer)Red cells without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse granules
composed of __________ that are reported as _________. -
(answer)Aggregated ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear is
characteristic of: - (answer)Multiple myeloma
Which of the following is most frequently associated with the inclusion bodies
seen in Color Plate 1? - (answer)Post-splenectomy
Which of the following statements about iron absorption is true? -
(answer)Absorption increases when erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules or
deposits? - (answer)Siderocyte
Which of the following is associated with a "shift to the left" in the oxygen
dissociation curve of hemoglobin? - (answer)Decreased oxygen release
Which of the following statements does not characterize erythropoietin (EPO)?
- (answer)Decreases stimulation of erythropoiesis when cellular hypoxia
increases
Which of the following factors will result in an immediate increase in oxygen
delivery to the tissues? - (answer)Increased hemoglobin binding of 2,3-BPG
