TEST BANK For Psychopharmacology Drugs the Brain and Behavior 3rd Edition By Meyer Nursing, Verified Chapters 1 - 20

Chapter 1: Principles of Pharmacology Multiple Choice 1. refer(s) to specific molecular changes that occur when a drug binds to a particular target site or receptor, while are the resulting widespread alterationsin function. a. Drug action; therapeutic effects b. Side effects; drug effects c. Therapeutic effects; side effects d. Drug action; drug effects ANSWER: d Textbook Reference: Pharmacology: The Science of Drug Action 2. After drug administration has occurred, the amount of drug in the blood that is free tobind at specific target sites is referred to as a. the therapeutic dose. b. first-pass effects. c. bioavailability. d. ED50. ANSWER: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 3. The specific molecular changes that occur when a drug binds to a particular target siteor receptor are referred to as a. drug effects. b. drug action. WWW.THENURSINGMASTERY.COM Page 4 of 247 c. side effects. d. placebo effects. ANSWER: b Textbook Reference: Pharmacology: The Science of Drug Action 4. Which of the following is not a possible explanation for placebo effects? a. Pavlovian conditioning b. Genetic variation c. Drug competition d. Expectation of outcome ANSWER: c Textbook Reference: Pharmacology: The Science of Drug Action WWW.THENURSINGMASTERY.COM Page 5 of 247 5. The administration of oxytocin has been proposed as a treatment for autism. a. intravenous b. oral c. intranasal d. intracerebral ANSWER: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 6. Which factor does not affect the pharmacokinetics of a drug? a. Route of administration b. Lipid solubility c. Depot binding d. Drug action ANSWER: d Textbook Reference: Pharmacokinetic Factors Determining Drug Action 7. First-pass metabolism occurs when drugs are taken a. orally. b. intravenously. c. subcutaneously. d. nasally. ANSWER: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 8. The area postrema is one area in the brain where the is not complete. a. cerebrospinal fluid b. blood–brain barrier c. choroid plexus d. phospholipid membrane ANSWER: b WWW.THENURSINGMASTERY.COM Page 6 of 247 Textbook Reference: Pharmacokinetic Factors Determining Drug Action 9. First-pass metabolism occurs with orally administered drugs because a. their absorption is slowed by food. b. drugs absorbed into the bloodstream from the stomach go to the liver on the way togeneral circulation. c. drugs must first survive the acidic environment of the stomach. d. salivary enzymes in the mouth begin the process of metabolism. ANSWER: b Textbook Reference: Pharmacokinetic Factors Determining Drug Action 10. Toxic substances in the blood trigger a vomiting response by activating the a. blood–brain barrier. b. choroid plexus. c. area postrema. d. median eminence. WWW.THENURSINGMASTERY.COM Page 7 of 247 ANSWER: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 11. Drugs administered _ have the most rapid onset of action. a. subcutaneously b. intramuscularly c. orally d. intravenously ANSWER: d Textbook Reference: Pharmacokinetic Factors Determining Drug Action 12. Ionization of a drug depends on the of the solution and the of thedrug. a. pH; pKa b. pKa; pH c. concentration; lipid solubility d. pH; concentration ANSWER: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 13. The absorption of a drug depends on all of the following except a. lipid solubility. b. ionization. c. body temperature. d. the concentration of the drug. ANSWER: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 14. Drugs that are should be avoided by women of childbearing age.