Test Bank Complete_
Huether and McCances Understanding Pathophysiology,
Canadian Edition 2nd Edition, (2023)
by Kelly Power-Kean, Stephanie Zettel, Mohamed Toufic El-
Hussein, Sue E. Huether, Kathryn L. McCance
All Chapters 1-42| + New! Chapter 43| Verified| 9780323778848| 2024-2025 Quest
,PART ONE: BASIC CONCEPTS OF PATHOPHYSIOLOGY ------------------------------------------------- 4
UNIT 1: The Cell ---------------------------------------------------------------------------------------------------------- 4
Chapter 01: Cellular Biology ------------------------------------------------------------------------------------------------------- 4
Chapter 02: Genes And Genetic Diseases ----------------------------------------------------------------------------------- 15
Chapter 03: Epigenetics And Disease ----------------------------------------------------------------------------------------- 31
Chapter 04: Altered Cellular And Tissue Biology--------------------------------------------------------------------------- 38
Chapter 05: Fluids And Electrolytes, Acids And Bases -------------------------------------------------------------------- 57
UNIT 2: Mechanisms of Self-Defense ----------------------------------------------------------------------------- 72
Chapter 06: Innate Immunity: Inflammation And Wound Healing --------------------------------------------------- 72
Chapter 07: Adaptive Immunity ------------------------------------------------------------------------------------------------ 91
Chapter 08: Infection And Defects In Mechanisms Of Defense ------------------------------------------------------ 100
Chapter 09: Stress And Disease ----------------------------------------------------------------------------------------------- 116
UNIT 3: Cellular Proliferation: Cancer --------------------------------------------------------------------------- 123
Chapter 10: Biology of Cancer ------------------------------------------------------------------------------------------------- 123
Chapter 11: Cancer Epidemiology -------------------------------------------------------------------------------------------- 132
Chapter 12: Cancer in Children and Adolescents ------------------------------------------------------------------------- 138
PART TWO: BODY SYSTEMS AND DISEASES ---------------------------------------------------------- 143
UNIT 4: The Neurologic System ----------------------------------------------------------------------------------- 143
Chapter 13: Structure And Function Of The Neurologic System ----------------------------------------------------- 143
Chapter 14: Pain, Temperature, Sleep, And Sensory Function ------------------------------------------------------- 160
Chapter 15: Alterations In Cognitive Systems, Cerebral Hemodynamics, And Motor Function ------------- 177
Chapter 16: Disorders Of The Central And Peripheral Nervous Systems And The Neuromuscular Junction
----------------------------------------------------------------------------------------------------------------------------------------- 193
Chapter 17: Alterations Of Neurologic Function In Children ---------------------------------------------------------- 212
UNIT 5: The Endocrine System ------------------------------------------------------------------------------------ 226
Chapter 18: Mechanisms Of Hormonal Regulation ---------------------------------------------------------------------- 226
Chapter 19: Alterations Of Hormonal Regulation ------------------------------------------------------------------------ 240
UNIT 6: The Hematologic System -------------------------------------------------------------------------------- 261
Chapter 20: Structure And Function Of The Hematologic System --------------------------------------------------- 261
Chapter 21: Alterations Of Hematologic Function ----------------------------------------------------------------------- 272
Chapter 22: Alterations Of Hematologic Function In Children -------------------------------------------------------- 299
UNIT 7: The Cardiovascular And Lymphatic Systems ------------------------------------------------------- 311
Chapter 23: Structure And Function Of The Cardiovascular And Lymphatic Systems -------------------------- 311
Chapter 24: Alterations Of Cardiovascular Function -------------------------------------------------------------------- 328
, Chapter 25: Alterations Of Cardiovascular Function In Children ----------------------------------------------------- 360
UNIT 8: The Pulmonary System ----------------------------------------------------------------------------------- 372
Chapter 26: Structure And Function Of The Pulmonary System ----------------------------------------------------- 372
Chapter 27: Alterations Of Pulmonary Function -------------------------------------------------------------------------- 386
Chapter 28: Alterations Of Pulmonary Function In Children ---------------------------------------------------------- 406
UNIT 9: The Renal and Urologic Systems ----------------------------------------------------------------------- 418
Chapter 29: Structure And Function Of The Renal And Urologic Systems ----------------------------------------- 418
Chapter 30: Alterations Of Renal And Urinary Tract Function -------------------------------------------------------- 431
Chapter 31: Alterations Of Renal And Urinary Tract Function In Children ----------------------------------------- 442
UNIT 10: The Reproductive Systems ---------------------------------------------------------------------------- 451
Chapter 32: Structure And Function Of The Reproductive Systems ------------------------------------------------- 451
Chapter 33: Alterations Of The Female Reproductive System -------------------------------------------------------- 465
Chapter 34: Alterations Of The Male Reproductive System ----------------------------------------------------------- 474
UNIT 11: The Digestive System ----------------------------------------------------------------------------------- 482
Chapter 35: Structure And Function Of The Digestive System -------------------------------------------------------- 482
Chapter 36: Alterations Of Digestive Function ---------------------------------------------------------------------------- 494
Chapter 37: Alterations Of Digestive Function In Children ------------------------------------------------------------ 515
UNIT 12: The Musculoskeletal and Integumentary Systems ---------------------------------------------- 529
Chapter 38: Structure And Function Of The Musculoskeletal System ---------------------------------------------- 529
Chapter 39: Alterations Of Musculoskeletal Function ------------------------------------------------------------------ 542
Chapter 40: Alterations Of Musculoskeletal Function In Children --------------------------------------------------- 558
Chapter 41: Structure, Function, And Disorders Of The Integument ----------------------------------------------- 567
Chapter 42: Alterations Of The Integument In Children ---------------------------------------------------------------- 582
NEW! Chapter 43: Co-morbidity and Multi-morbidities (Title And Placement TBD) ------- 589
,PART ONE: BASIC CONCEPTS OF PATHOPHYSIOLOGY
UNIT 1: The Cell
Chapter 01: Cellular Biology
Kelly Power-Kean: Huether And Mccance’s Understanding Pathophysiology, Canadian
2nd Edition (2023) Test Bank
MULTIPLE CHOICE
1. A Student Is Observing A Cell Under The Microscope. It Is Observed To Have
Supercoiled DNA With Histones. Which Of The Following Would Also Be Observed
By The Student?
A. A Single Circular Chromosome
B. A Nucleus
C. Free-Floating Nuclear Material
D. No Organelles
ANS: B
The Cell Described Is A Eukaryotic Cell, So It Has Histones And A Supercoiled
DNA Within Its Nucleus; Thus, The Nucleus Should Be Observed. A Single Circular
Chromosome Called A Prokaryote Contains Free-Floating Nuclear Material But Has
No Organelles.
DIF: Cognitive Level: Remembering REF: Nucleus
TOP: Physiological Integrity
2. A Nurse Is Instructing The Staff About Cellular Functions. Which Cellular
Function Is The Nurse Describing When An Isolated Cell Absorbs Oxygen And Uses
It To Transform Nutrients To Energy?
A. Metabolic Absorption
B. Communication
C. Secretion
D. Respiration
ANS: D
The Cell’s Ability To Absorb Oxygen Is Referred To As Respiration While Its
Communication Ability Involves Maintenance Of A Steady Dynamic State, Metabolic
Absorption Provides Nutrition, And Secretion Allows For The Synthesizing Of New
Substances.
DIF: Cognitive Level: Remembering REF: Cellular Functions
TOP: Physiological Integrity
3. A Eukaryotic Cell Is Undergoing DNA Replication. In Which Region Of The Cell
Would Most Of The Genetic Information Be Contained?
,A. Mitochondria
B. Ribosome
C. Nucleolus
D. Nucleus Cytoplasm
ANS: C
The Region Of The Cell That Contains Genetic Material, Including A Large Amount
Of Ribonucleic Acid, Most Of The DNA, And DNA-Binding Proteins, Is The
Nucleolus, Which Is Located Within The Cell’s Nucleus. Mitochondria Is Associated
With Cellular Respiration, While Ribosomes Are Involved With Protein
Manufacturing. Cytoplasm Is A Fluid Filling That Is A Component Of The Cell.
DIF: Cognitive Level: Remembering REF: Nucleus
TOP: Physiological Integrity
4. Which Of The Following Can Remove Proteins Attached To The Cell’s Bilayer By
Dissolving The Layer Itself?
A. Peripheral Membrane Proteins
B. Integral Membrane Proteins
C. Glycoproteins
D. Cell Adhesion Molecules
ANS: B
Proteins Directly Attached To The Membrane Bilayer Can Be Removed By The
Action Of Integral Membrane Proteins That Dissolve The Bilayer. Peripheral
Membrane Proteins Reside At The Surface While Cell Adhesion Molecules Are On
The Outside Of The Membrane. Glycoprotein Marks Cells And Does Not Float.
DIF: Cognitive Level: Remembering REF: Membrane Composition
TOP: Physiological Integrity
5. Which Of The Following Can Bind To Plasma Membrane Receptors?
A. Oxygen
B. Ribosomes
C. Amphipathic Lipids
D. Ligands
ANS: D
Ligands Are The Only Specific Molecules That Can Bind With Receptors On The
Cell Membrane.
DIF: Cognitive Level: Remembering REF: Cellular Receptors
TOP: Physiological Integrity
6. A Nurse Is Reviewing A Report From A Patient With Metastatic Cancer. What
Alternation In The Extracellular Matrix Would Support The Diagnostics Of metastatic
Cancer?
A. Decreased Fibronectin
B. Increased Collagen
, C. Decreased Elastin
D. Increased Glycoproteins
ANS: A
Only A Reduced Amount Of Fibronectin Is Found In Some Types Of Cancerous
Cells, Allowing Them To Travel Or Metastasize.
DIF: Cognitive Level: Remembering REF: Extracellular matrix
TOP: Physiological Integrity
7. Which Form Of Cell Communication Is Used To Relate To Other Cells In Direct
Physical Contact?
A. Cell Junction
B. Gap Junction
C. Desmosome
D. Tight Junction
ANS: A
Cell Junctions Hold Cells Together And Permit Molecules To Pass From Cell To
Cell.
Gap Junctions Allow For Cellular Communication Between Cells. Neither
Desmosomes Nor Tight Junctions Are Associated With Cellular Communication.
DIF: Cognitive Level: Remembering REF: Membrane Composition
TOP: Physiological Integrity
8. Pancreatic Beta Cells Secrete Insulin, Which Inhibits Secretion Of Glucagon From
Neighbouring Alpha Cells. This Action Is An Example Of Which Of The Following
Signalling Types?
A. Paracrine
B. Autocrine
C. Neurohormonal
D. Hormonal
ANS: A
Paracrine Signalling Involves The Release Of Local Chemical Mediators That Are
Quickly Taken Up, Destroyed, Or Immobilized, As In The Case Of Insulin And The
Inhibition Of The Secretion Of Glucagon. None Of The Other Options Involve
Signalling That Is Associated With A Local Chemical Mediator Like Insulin.
DIF: Cognitive Level: Remembering
REF: Cellular Communication And Signal Transduction
TOP: Physiological Integrity
9. In Cellular Metabolism, Each Enzyme Has A High Affinity For A:
A. Solute.
B. Substrate.
C. Receptor.
D. Ribosome.
Huether and McCances Understanding Pathophysiology,
Canadian Edition 2nd Edition, (2023)
by Kelly Power-Kean, Stephanie Zettel, Mohamed Toufic El-
Hussein, Sue E. Huether, Kathryn L. McCance
All Chapters 1-42| + New! Chapter 43| Verified| 9780323778848| 2024-2025 Quest
,PART ONE: BASIC CONCEPTS OF PATHOPHYSIOLOGY ------------------------------------------------- 4
UNIT 1: The Cell ---------------------------------------------------------------------------------------------------------- 4
Chapter 01: Cellular Biology ------------------------------------------------------------------------------------------------------- 4
Chapter 02: Genes And Genetic Diseases ----------------------------------------------------------------------------------- 15
Chapter 03: Epigenetics And Disease ----------------------------------------------------------------------------------------- 31
Chapter 04: Altered Cellular And Tissue Biology--------------------------------------------------------------------------- 38
Chapter 05: Fluids And Electrolytes, Acids And Bases -------------------------------------------------------------------- 57
UNIT 2: Mechanisms of Self-Defense ----------------------------------------------------------------------------- 72
Chapter 06: Innate Immunity: Inflammation And Wound Healing --------------------------------------------------- 72
Chapter 07: Adaptive Immunity ------------------------------------------------------------------------------------------------ 91
Chapter 08: Infection And Defects In Mechanisms Of Defense ------------------------------------------------------ 100
Chapter 09: Stress And Disease ----------------------------------------------------------------------------------------------- 116
UNIT 3: Cellular Proliferation: Cancer --------------------------------------------------------------------------- 123
Chapter 10: Biology of Cancer ------------------------------------------------------------------------------------------------- 123
Chapter 11: Cancer Epidemiology -------------------------------------------------------------------------------------------- 132
Chapter 12: Cancer in Children and Adolescents ------------------------------------------------------------------------- 138
PART TWO: BODY SYSTEMS AND DISEASES ---------------------------------------------------------- 143
UNIT 4: The Neurologic System ----------------------------------------------------------------------------------- 143
Chapter 13: Structure And Function Of The Neurologic System ----------------------------------------------------- 143
Chapter 14: Pain, Temperature, Sleep, And Sensory Function ------------------------------------------------------- 160
Chapter 15: Alterations In Cognitive Systems, Cerebral Hemodynamics, And Motor Function ------------- 177
Chapter 16: Disorders Of The Central And Peripheral Nervous Systems And The Neuromuscular Junction
----------------------------------------------------------------------------------------------------------------------------------------- 193
Chapter 17: Alterations Of Neurologic Function In Children ---------------------------------------------------------- 212
UNIT 5: The Endocrine System ------------------------------------------------------------------------------------ 226
Chapter 18: Mechanisms Of Hormonal Regulation ---------------------------------------------------------------------- 226
Chapter 19: Alterations Of Hormonal Regulation ------------------------------------------------------------------------ 240
UNIT 6: The Hematologic System -------------------------------------------------------------------------------- 261
Chapter 20: Structure And Function Of The Hematologic System --------------------------------------------------- 261
Chapter 21: Alterations Of Hematologic Function ----------------------------------------------------------------------- 272
Chapter 22: Alterations Of Hematologic Function In Children -------------------------------------------------------- 299
UNIT 7: The Cardiovascular And Lymphatic Systems ------------------------------------------------------- 311
Chapter 23: Structure And Function Of The Cardiovascular And Lymphatic Systems -------------------------- 311
Chapter 24: Alterations Of Cardiovascular Function -------------------------------------------------------------------- 328
, Chapter 25: Alterations Of Cardiovascular Function In Children ----------------------------------------------------- 360
UNIT 8: The Pulmonary System ----------------------------------------------------------------------------------- 372
Chapter 26: Structure And Function Of The Pulmonary System ----------------------------------------------------- 372
Chapter 27: Alterations Of Pulmonary Function -------------------------------------------------------------------------- 386
Chapter 28: Alterations Of Pulmonary Function In Children ---------------------------------------------------------- 406
UNIT 9: The Renal and Urologic Systems ----------------------------------------------------------------------- 418
Chapter 29: Structure And Function Of The Renal And Urologic Systems ----------------------------------------- 418
Chapter 30: Alterations Of Renal And Urinary Tract Function -------------------------------------------------------- 431
Chapter 31: Alterations Of Renal And Urinary Tract Function In Children ----------------------------------------- 442
UNIT 10: The Reproductive Systems ---------------------------------------------------------------------------- 451
Chapter 32: Structure And Function Of The Reproductive Systems ------------------------------------------------- 451
Chapter 33: Alterations Of The Female Reproductive System -------------------------------------------------------- 465
Chapter 34: Alterations Of The Male Reproductive System ----------------------------------------------------------- 474
UNIT 11: The Digestive System ----------------------------------------------------------------------------------- 482
Chapter 35: Structure And Function Of The Digestive System -------------------------------------------------------- 482
Chapter 36: Alterations Of Digestive Function ---------------------------------------------------------------------------- 494
Chapter 37: Alterations Of Digestive Function In Children ------------------------------------------------------------ 515
UNIT 12: The Musculoskeletal and Integumentary Systems ---------------------------------------------- 529
Chapter 38: Structure And Function Of The Musculoskeletal System ---------------------------------------------- 529
Chapter 39: Alterations Of Musculoskeletal Function ------------------------------------------------------------------ 542
Chapter 40: Alterations Of Musculoskeletal Function In Children --------------------------------------------------- 558
Chapter 41: Structure, Function, And Disorders Of The Integument ----------------------------------------------- 567
Chapter 42: Alterations Of The Integument In Children ---------------------------------------------------------------- 582
NEW! Chapter 43: Co-morbidity and Multi-morbidities (Title And Placement TBD) ------- 589
,PART ONE: BASIC CONCEPTS OF PATHOPHYSIOLOGY
UNIT 1: The Cell
Chapter 01: Cellular Biology
Kelly Power-Kean: Huether And Mccance’s Understanding Pathophysiology, Canadian
2nd Edition (2023) Test Bank
MULTIPLE CHOICE
1. A Student Is Observing A Cell Under The Microscope. It Is Observed To Have
Supercoiled DNA With Histones. Which Of The Following Would Also Be Observed
By The Student?
A. A Single Circular Chromosome
B. A Nucleus
C. Free-Floating Nuclear Material
D. No Organelles
ANS: B
The Cell Described Is A Eukaryotic Cell, So It Has Histones And A Supercoiled
DNA Within Its Nucleus; Thus, The Nucleus Should Be Observed. A Single Circular
Chromosome Called A Prokaryote Contains Free-Floating Nuclear Material But Has
No Organelles.
DIF: Cognitive Level: Remembering REF: Nucleus
TOP: Physiological Integrity
2. A Nurse Is Instructing The Staff About Cellular Functions. Which Cellular
Function Is The Nurse Describing When An Isolated Cell Absorbs Oxygen And Uses
It To Transform Nutrients To Energy?
A. Metabolic Absorption
B. Communication
C. Secretion
D. Respiration
ANS: D
The Cell’s Ability To Absorb Oxygen Is Referred To As Respiration While Its
Communication Ability Involves Maintenance Of A Steady Dynamic State, Metabolic
Absorption Provides Nutrition, And Secretion Allows For The Synthesizing Of New
Substances.
DIF: Cognitive Level: Remembering REF: Cellular Functions
TOP: Physiological Integrity
3. A Eukaryotic Cell Is Undergoing DNA Replication. In Which Region Of The Cell
Would Most Of The Genetic Information Be Contained?
,A. Mitochondria
B. Ribosome
C. Nucleolus
D. Nucleus Cytoplasm
ANS: C
The Region Of The Cell That Contains Genetic Material, Including A Large Amount
Of Ribonucleic Acid, Most Of The DNA, And DNA-Binding Proteins, Is The
Nucleolus, Which Is Located Within The Cell’s Nucleus. Mitochondria Is Associated
With Cellular Respiration, While Ribosomes Are Involved With Protein
Manufacturing. Cytoplasm Is A Fluid Filling That Is A Component Of The Cell.
DIF: Cognitive Level: Remembering REF: Nucleus
TOP: Physiological Integrity
4. Which Of The Following Can Remove Proteins Attached To The Cell’s Bilayer By
Dissolving The Layer Itself?
A. Peripheral Membrane Proteins
B. Integral Membrane Proteins
C. Glycoproteins
D. Cell Adhesion Molecules
ANS: B
Proteins Directly Attached To The Membrane Bilayer Can Be Removed By The
Action Of Integral Membrane Proteins That Dissolve The Bilayer. Peripheral
Membrane Proteins Reside At The Surface While Cell Adhesion Molecules Are On
The Outside Of The Membrane. Glycoprotein Marks Cells And Does Not Float.
DIF: Cognitive Level: Remembering REF: Membrane Composition
TOP: Physiological Integrity
5. Which Of The Following Can Bind To Plasma Membrane Receptors?
A. Oxygen
B. Ribosomes
C. Amphipathic Lipids
D. Ligands
ANS: D
Ligands Are The Only Specific Molecules That Can Bind With Receptors On The
Cell Membrane.
DIF: Cognitive Level: Remembering REF: Cellular Receptors
TOP: Physiological Integrity
6. A Nurse Is Reviewing A Report From A Patient With Metastatic Cancer. What
Alternation In The Extracellular Matrix Would Support The Diagnostics Of metastatic
Cancer?
A. Decreased Fibronectin
B. Increased Collagen
, C. Decreased Elastin
D. Increased Glycoproteins
ANS: A
Only A Reduced Amount Of Fibronectin Is Found In Some Types Of Cancerous
Cells, Allowing Them To Travel Or Metastasize.
DIF: Cognitive Level: Remembering REF: Extracellular matrix
TOP: Physiological Integrity
7. Which Form Of Cell Communication Is Used To Relate To Other Cells In Direct
Physical Contact?
A. Cell Junction
B. Gap Junction
C. Desmosome
D. Tight Junction
ANS: A
Cell Junctions Hold Cells Together And Permit Molecules To Pass From Cell To
Cell.
Gap Junctions Allow For Cellular Communication Between Cells. Neither
Desmosomes Nor Tight Junctions Are Associated With Cellular Communication.
DIF: Cognitive Level: Remembering REF: Membrane Composition
TOP: Physiological Integrity
8. Pancreatic Beta Cells Secrete Insulin, Which Inhibits Secretion Of Glucagon From
Neighbouring Alpha Cells. This Action Is An Example Of Which Of The Following
Signalling Types?
A. Paracrine
B. Autocrine
C. Neurohormonal
D. Hormonal
ANS: A
Paracrine Signalling Involves The Release Of Local Chemical Mediators That Are
Quickly Taken Up, Destroyed, Or Immobilized, As In The Case Of Insulin And The
Inhibition Of The Secretion Of Glucagon. None Of The Other Options Involve
Signalling That Is Associated With A Local Chemical Mediator Like Insulin.
DIF: Cognitive Level: Remembering
REF: Cellular Communication And Signal Transduction
TOP: Physiological Integrity
9. In Cellular Metabolism, Each Enzyme Has A High Affinity For A:
A. Solute.
B. Substrate.
C. Receptor.
D. Ribosome.
