MSN 571 Complete Questions with A+ Graded Answers|Latest Update

MSN 571 Complete Questions with A+ Graded Answers|Latest Update Prescriptive authority legal authority granted to advanced practice nurses to prescribe medication; DETERMINED BY STATE LAW Rational Drug Selection based on individual patient and addresses disease specific information: ONLY A GUIDELINE Drug Selection includes analysis of cost, guidelines, avaibalbility, interactions, side effects, allergies, hepatic and renal function, need for monitoring, special precautions i.e elderly medication education basic components medication name purpose dosing regimen administration adverse effects any storage needs associated labs testing food & drug interactions duration of therapy medication adherence barriers to adherence= forgetfulness lack of planning cost dissatisfaction altered dosing Phamacokinetics study of drug movement throughout body principles of pharmacokinetics absorption distribution metabolism excretion Passage of drugs across membranes - channels and pores - transport systems (P-glycoprotein) - direct penetration of the membrane Absorption of drugs Transfer of drugs from site of administration across cell membrane into the blood stream factors that affect absorption of drugs rate of dissolution- how easy dissolves surface area- >surface area moves faster blood flow- >blood flow moves faster lipid solubility - lipid easily cross membrane ph partitioning - Distribution of drugs movement of drugs from systemic circulation to site of drug action factors that determine drug flow blood flow to tissues ability to exit vascular system ability to enter cell Drug ability to exit vascular system capillary bed- typical blood brain barreier placenta drug transfer protein binding - albumin drug ability to enter cell binds with receptors on external surface of cell membrane drug metabolism the enzymatic biotransformation of a drug structure most occur in liver by P450 system first pass effect rapid hepatic inactivation of drug on its first pass through liver drug excretion elimination of a drug from the body Drug Excretion Routes renal breast milk bile lungs sweat saliva therapeutic drug range range of drug between minimum effective dose and toxic dose. larger index - safer dose smaller index- harmful dose