Test Bank Karch's Focus on
Nursing Pharmacology
9th Edition By Rebecca
Tucker All Chapters.
The patient has a diagnosis of multiple sclerosis and is taking the drug interferon beta-1a
(Rebif). The patient takes this drug by subcutaneous injection three times a week.
The dosage is 44 mcg per injection. If the patient takes an injection on Monday,
how much of the drug would still be in the patient’s system when she takes her
next injection on Wednesday, assuming the half-life of the drug is24 hours?
A. 22 mcg
B. 16.5 mcg
C. 11 mcg
D. 5.5 mcg
Ans: C
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to 1 half the peak level it previously achieved. On Tuesday, there would be
22 mcg remaining in the body, so option A is incorrect. On Wednesday 11 mcg would
remain, so option C is the correct answer. At 12 hours before taking the next dose on
Wednesday, there would be 16.5 mcg remaining. If the injection were not taken on
Wednesday, 12 hours after the dose was due, there would be 5.5 mcg remaining.
The patient is a 6-year-old child who is taking 125 mg of amoxicillin every 6 hours.
Assuming that thehalf- life of Amoxicillin is 3 hours, how much Amoxicillin would
be in the child’s body at the time of the next administration of the drug?
,A) 62.5 mg
B) 46.875 mg
C) 31.25 mg
D) 15.625 mg
Ans: C
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to 1 half the peak level it previously achieved. Option A would occur at 3
hours after the original dose of amoxicillin. Option B would occur 4 1/2 hours after
the original dose. Option C would occur at 6 hours after the original dose. Option D
would occur at 7 1/2 hours after the original dose.
A drug with a half-life of 4 hours is administered at a dosage of 100 mg. How much of the
drug will bein the patient’s system 8 hours after administration?
A. 75 mg
B. 50 mg
C. 37.5 mg
D. 25 mg
Ans: D
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to 1 half the peak level it previously achieved. Option A would occur 2
hours after administration of the drug.
, Option B would occur at 4 hours. Option C would occur at 6 hours. Option D would
occur at 8 hoursafter the original administration of the drug.
The nurse administers amoxicillin 500 mg. The half-life of this drug is approximately 1
hour. At whatpointwould the drug level in the body be 62.5 mg if the drug was
not administered again?
A. 1 hours after the original dose
B. 2 hours after the original dose
C. 3 hours after the original dose
D. 4 hours after the original dose
Ans: C
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to one-half of the peak level it previously achieved. At a dose of 500 mg
the drug level would be 250 mg in 1 hour, 125 mg in 2 hours, 62.5 mg in 3 hours,
and 31.25 mg in 4 hours so the correct answer is 3 hours.
The nurse is caring for a patient who is receiving gentamicin, 250 mg and fluconazole
(Diflucan), 500mg at the same time. The nurse knows that if these two drugs
competed with each other for protein- binding sites, what would this do?
A. Make the patient gentamicin deficient
B. Make the patient fluconazole deficient
C. Counteract any positive benefit the drugs would have
D. Alter the effectiveness of
both drugs
• Ans: D
Feedback:
, Some drugs compete with each other for protein-binding sites, altering effectiveness or
causing toxicity when the two drugs are given together. Nothing in the scenario would
indicate that the patient would be either Gentamicin or Diflucan deficient, nor does it
indicate that these drugs cannot be given together because they would counteract each
other.
The student nurse asks the instructor why a patient with a central nervous system infection
is receiving antibiotics that will not cross the bloodbrain barrier. What is the
instructor’s most correct response?
A. A severe infection alters the bloodbrain barrier to allow the drug to cross.
B. A medication that is water soluble is more likely to cross the blood-brain barrier.
C. Antibiotics are the exception to the bloodbrain barrier and cross easily.
D. An infection that spreads outside the central nervous system helps drugs cross the barrier.
Ans: A
Feedback:
Effective antibiotic treatment can occur only when the infection is severe enough to
alter the bloodbrain barrier and allow antibiotics to cross. Lipid-soluble, not water-
soluble, medications cross the bloodbrain barrier more easily and most antibiotics
are lipid soluble, so they are not the exception. No matter where the infection
originates, drugs must cross the bloodbrain barrier to treat central nervous system
infections.
The patient is taking low dose aspirin daily for his heart. The nurse knows only
a portion of the medication taken actually reaches the tissue due to what
process?
A. Distribution
B. First-pass effect
C. Reduced absorption
D. Gastrointestinal circulation
Nursing Pharmacology
9th Edition By Rebecca
Tucker All Chapters.
The patient has a diagnosis of multiple sclerosis and is taking the drug interferon beta-1a
(Rebif). The patient takes this drug by subcutaneous injection three times a week.
The dosage is 44 mcg per injection. If the patient takes an injection on Monday,
how much of the drug would still be in the patient’s system when she takes her
next injection on Wednesday, assuming the half-life of the drug is24 hours?
A. 22 mcg
B. 16.5 mcg
C. 11 mcg
D. 5.5 mcg
Ans: C
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to 1 half the peak level it previously achieved. On Tuesday, there would be
22 mcg remaining in the body, so option A is incorrect. On Wednesday 11 mcg would
remain, so option C is the correct answer. At 12 hours before taking the next dose on
Wednesday, there would be 16.5 mcg remaining. If the injection were not taken on
Wednesday, 12 hours after the dose was due, there would be 5.5 mcg remaining.
The patient is a 6-year-old child who is taking 125 mg of amoxicillin every 6 hours.
Assuming that thehalf- life of Amoxicillin is 3 hours, how much Amoxicillin would
be in the child’s body at the time of the next administration of the drug?
,A) 62.5 mg
B) 46.875 mg
C) 31.25 mg
D) 15.625 mg
Ans: C
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to 1 half the peak level it previously achieved. Option A would occur at 3
hours after the original dose of amoxicillin. Option B would occur 4 1/2 hours after
the original dose. Option C would occur at 6 hours after the original dose. Option D
would occur at 7 1/2 hours after the original dose.
A drug with a half-life of 4 hours is administered at a dosage of 100 mg. How much of the
drug will bein the patient’s system 8 hours after administration?
A. 75 mg
B. 50 mg
C. 37.5 mg
D. 25 mg
Ans: D
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to 1 half the peak level it previously achieved. Option A would occur 2
hours after administration of the drug.
, Option B would occur at 4 hours. Option C would occur at 6 hours. Option D would
occur at 8 hoursafter the original administration of the drug.
The nurse administers amoxicillin 500 mg. The half-life of this drug is approximately 1
hour. At whatpointwould the drug level in the body be 62.5 mg if the drug was
not administered again?
A. 1 hours after the original dose
B. 2 hours after the original dose
C. 3 hours after the original dose
D. 4 hours after the original dose
Ans: C
Feedback:
The half-life of a drug is the time it takes for the amount of drug in the body to
decrease to one-half of the peak level it previously achieved. At a dose of 500 mg
the drug level would be 250 mg in 1 hour, 125 mg in 2 hours, 62.5 mg in 3 hours,
and 31.25 mg in 4 hours so the correct answer is 3 hours.
The nurse is caring for a patient who is receiving gentamicin, 250 mg and fluconazole
(Diflucan), 500mg at the same time. The nurse knows that if these two drugs
competed with each other for protein- binding sites, what would this do?
A. Make the patient gentamicin deficient
B. Make the patient fluconazole deficient
C. Counteract any positive benefit the drugs would have
D. Alter the effectiveness of
both drugs
• Ans: D
Feedback:
, Some drugs compete with each other for protein-binding sites, altering effectiveness or
causing toxicity when the two drugs are given together. Nothing in the scenario would
indicate that the patient would be either Gentamicin or Diflucan deficient, nor does it
indicate that these drugs cannot be given together because they would counteract each
other.
The student nurse asks the instructor why a patient with a central nervous system infection
is receiving antibiotics that will not cross the bloodbrain barrier. What is the
instructor’s most correct response?
A. A severe infection alters the bloodbrain barrier to allow the drug to cross.
B. A medication that is water soluble is more likely to cross the blood-brain barrier.
C. Antibiotics are the exception to the bloodbrain barrier and cross easily.
D. An infection that spreads outside the central nervous system helps drugs cross the barrier.
Ans: A
Feedback:
Effective antibiotic treatment can occur only when the infection is severe enough to
alter the bloodbrain barrier and allow antibiotics to cross. Lipid-soluble, not water-
soluble, medications cross the bloodbrain barrier more easily and most antibiotics
are lipid soluble, so they are not the exception. No matter where the infection
originates, drugs must cross the bloodbrain barrier to treat central nervous system
infections.
The patient is taking low dose aspirin daily for his heart. The nurse knows only
a portion of the medication taken actually reaches the tissue due to what
process?
A. Distribution
B. First-pass effect
C. Reduced absorption
D. Gastrointestinal circulation
