Oxford Cambridge and
RSA Examinations
GCEBiology BH422/02:
Scientific literacy in
biologyA Level with
marking scheme.
, Oxford Cambridge and RSA
Friday 16 June 2023 – Morning
A Level Biology B (Advancing Biology)
H422/02 Scientific literacy in biology
Time allowed: 2 hours 15 minutes
You must have:
* 9 8 9 7 8 5 5 9 9 0 *
• a clean copy of the Advance Notice Article (inside
this document)
• the Insert (inside this document)
You can use:
• a scientific or graphical calculator
• a ruler (cm/mm)
* H 4 2 2 0 2 *
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 100.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 28 pages.
ADVICE
• Read each question carefully before you start your answer.
© OCR 2023 [601/4720/9] OCR is an exempt Charity
DC (ST/JG) 317619/3 Turn over
, 2
1 This question is based on the Advance Notice Article ‘Development of therapeutic antibodies
for the treatment of disease’.
(a) (i) State what is meant by the term antigen.
...........................................................................................................................................
...................................................................................................................................... [1]
(ii) Scientists can combine antibody fragments using phage display to produce many
different antibodies, each specific to a different antigen.
Using the abbreviations from Fig. 1 in the Advance Notice Article, explain how
combining antibody fragments allows scientists to produce many different antibodies,
each specific to a different antigen.
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...................................................................................................................................... [2]
(iii) The B cell receptor is an IgG molecule with the same structure as the human IgG
shown in Fig. 1 in the Advance Notice Article.
Use an abbreviation from Fig. 1 to identify the part of the B cell receptor that will be
attached to the cell surface membrane of a B cell.
...................................................................................................................................... [1]
© OCR 2023
, 3
(b) (i) Explain why mouse monoclonal antibodies (mAbs) have been largely replaced as
therapeutic antibodies by humanised or fully human mAbs.
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...................................................................................................................................... [2]
(ii) Explain why the Fab and scFv antibody fragments shown in Fig. 1 are effective as
neutralizing or agglutinating antibodies but are less effective as opsonins or in activation
of complement.
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...................................................................................................................................... [2]
© OCR 2023 Turn over
RSA Examinations
GCEBiology BH422/02:
Scientific literacy in
biologyA Level with
marking scheme.
, Oxford Cambridge and RSA
Friday 16 June 2023 – Morning
A Level Biology B (Advancing Biology)
H422/02 Scientific literacy in biology
Time allowed: 2 hours 15 minutes
You must have:
* 9 8 9 7 8 5 5 9 9 0 *
• a clean copy of the Advance Notice Article (inside
this document)
• the Insert (inside this document)
You can use:
• a scientific or graphical calculator
• a ruler (cm/mm)
* H 4 2 2 0 2 *
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 100.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 28 pages.
ADVICE
• Read each question carefully before you start your answer.
© OCR 2023 [601/4720/9] OCR is an exempt Charity
DC (ST/JG) 317619/3 Turn over
, 2
1 This question is based on the Advance Notice Article ‘Development of therapeutic antibodies
for the treatment of disease’.
(a) (i) State what is meant by the term antigen.
...........................................................................................................................................
...................................................................................................................................... [1]
(ii) Scientists can combine antibody fragments using phage display to produce many
different antibodies, each specific to a different antigen.
Using the abbreviations from Fig. 1 in the Advance Notice Article, explain how
combining antibody fragments allows scientists to produce many different antibodies,
each specific to a different antigen.
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...................................................................................................................................... [2]
(iii) The B cell receptor is an IgG molecule with the same structure as the human IgG
shown in Fig. 1 in the Advance Notice Article.
Use an abbreviation from Fig. 1 to identify the part of the B cell receptor that will be
attached to the cell surface membrane of a B cell.
...................................................................................................................................... [1]
© OCR 2023
, 3
(b) (i) Explain why mouse monoclonal antibodies (mAbs) have been largely replaced as
therapeutic antibodies by humanised or fully human mAbs.
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...................................................................................................................................... [2]
(ii) Explain why the Fab and scFv antibody fragments shown in Fig. 1 are effective as
neutralizing or agglutinating antibodies but are less effective as opsonins or in activation
of complement.
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...........................................................................................................................................
...................................................................................................................................... [2]
© OCR 2023 Turn over
