BIOCHEM C785 2ndOA (1)/ BIOCHEM C785 Readiness Questions with answers/BIOCHEM C785 BIO notes latest 2022/ BIOCHEM C785 2 OA readiness check complete/ Biochemistry Readiness Check II (Download to score an A)/ BIOCHEM C785 pre assessment #3

BIOCHEM C785 2ndOA (1)/ BIOCHEM C785 Readiness Questions with answers/BIOCHEM C785 BIO notes latest 2022/ BIOCHEM C785 2 OA readiness check complete/ Biochemistry Readiness Check II (Download to score an A)/ BIOCHEM C785 pre assessment #3 The 2nd OA Readiness Check is designed to give you additional practice with new assessment-style questions to help prepare for success on the OA. Thus, please try to mimic exam-like conditions by taking the test in one <2 hr sitting without any study aids apart from your whiteboard/scrap paper. Note: You can take the 2nd OA Readiness Check again if you're so inclined, but you can not edit your response as you may have done with the topic questions. You will be able to see the results afterwards. What is the complementary sequence to 3’ ATG CGA ATA 5’? * 1/1 3’ TAT TCG CAT 5’ 3’ TAC GCT TAT 5’ 3’ GAT AGC ATA 5’ 5’ ATA AGC GTA 3’ Which amino acid sequence would result from this Coding DNA strand? 3’ ATG CAG ATA 5’? * 1/1 Tyr Val Tyr Ile Gln Ile Ile Asp Val Leu His Lys Which amino acid sequence would be made from this template DNA strand? 5’ TAT TAC CGA 3’? * 0/1 Tyr Tyr Arg Ile Met Ala Ser Val Ile Ser His Gln Which of the following are the correct components for a PCR reaction? * 1/1 dNTPs, Primer, RNA Polymerase, template RNA dNTPs, Primer, DNA Polymerase, template DNA ATP, Primer, mRNA polymerase; template mRNA Acetyl CoA, RNA primer, DNA Ligase, Template phosphate If you had a mother who is homozygous for a recessive disease, and a father who is a heterozygous carrier, what percentage of children will have the disease? * 1/1 0% 25% 50% 75% 100% Which of the following would represent a silent mutation if this is the original sequence: 5’ AUC GUA ACA 3’? * 1/1 5’ AUC GGA ACA 3’ 5’ AUA GUA ACA 3’ 5’ AUC GUA UAA 3’ 5’ AUC CUC ACA 3’ If the original coding sequence is 5’ CGA TAC TTC AGA 3’ and it is mutated to 5' CGA TAT TTC AGA 3', what type of mutation would have taken place? * 1/1 Silent Missense Nonsense Insertion Huntington's is an autosomal dominant disorder. Which of the following chromosome pairs would be inherited by a person with Huntington's Disease? (Yellow box = Dominant allele, Green box = Recessive allele) * 1/1 Option 1 Option 2 Option 3 Option 4 The pedigree below tracks Duchenne Muscular Dystrophy (DMD) through several generations. What type of inheritance does DMD express? * 0/1 Autosomal dominant Autosomal recessive X-linked Dominant X- Linked recessive Rett syndrome is a brain disorder that occurs almost exclusively in females, causing severe deficits in language, learning, coordination and other brain functions. Decreased expression of the MECP2 gene causes Rett syndrome. Which of the following scenarios correctly describes how Rett syndrome could be developed? * 1/1 A DNA-binding protein blocks RNA Polymerase from binding to the promoter sequence, facilitating the transcription of the MECP2 gene. Transcription factors are unable to bind to the transcription start site of the MECP2 gene because nucleosomes are tightly packed together. Transcription activators cause nucleosomes to separate, exposing the MECP2 gene. RNA Polymerase binds to the MECP2 gene and begins translation. Which of the following strands are complementary and anti- parallel? * 1/1 Coding and Non-template Template and mRNA Coding and mRNA Template and tRNA What is the correct order of the Central Dogma? * 1/1 Translation, Replication, Transcription Transcription, Replication, Translation Translation, Transcription, Replication Replication, Transcription, Translation What happens when the incorrect base is added during the synthesis of a DNA strand in DNA replication? * 1/1 The homologous chromosome is used to replace the incorrectly added base with the correct one. DNA Polymerase removes the incorrect base and adds in the correct base. Thymine dimers occur. Distortion of the double helix occurs and is repaired by RNA Polymerase. What is the correct definition of nucleotide excision repair? * 1/1 Removal of a single damaged nucleotide Damage to a few or several nucleotides are identified, then many nucleotides are removed and all are replaced to repair the DNA segment Required when there are breaks in the double stranded DNA strand which causes discontinuity in both strands Insertion of a thymine dimer What type of interactions would be affected in a patient with diabetic ketoacidosis? (select all that apply) * 0/1 Ionic bonds Disulfide bonds On a hot summer's day, I was cleaning my garage. My cat Sophie was out with me, and got into a bottle containing a strong reducing agent. Of course I took her straight to the vet. What type of amino acid bonds would be disrupted by exposure to the strong reducing agent? * 1/1 Hydrophobic interactions Hydrogen bonds Disulfide bonds Ionic bonds What type of bond can the amino acids below form to stabilize the tertiary structure of a protein? * 1/1 Ionic bond Hydrophobic interaction Hydrogen bond Disulfide bond What type of reaction forms the primary structure of a protein? * 1/1 Activation energy Enzymes Dehydration Hydrolysis Myoglobin is an oxygen storage protein and exhibits a hyperbolic curve in an oxygen saturation graph. What is the highest level of protein structure exhibited by myoglobin? * 1/1 Primary Secondary Tertiary Quaternary What level of protein structure involves alpha helices and beta pleated sheets? * 1/1 Primary Secondary Tertiary Quaternary Hydrogen bonds between backbone groups stabilize what level of protein structure? * 1/1 Primary Secondary Tertiary Quaternary Which of the following is true about protein structure and function? * 0/1 A protein has optimal function in its primary structure. All proteins carry out cellular functions when they have obtained their final quaternary structure. Ionic bonds between the backbone groups of amino acids stabilize a protein's tertiary structure. The hydrophobic effect primarily contributes to a single subunit protein's tertiary structure. Glutamine is located at position 13, of a protein, and forms a hydrogen bond with the amino acid at position 89. What would happen if the amino acid at position 89 was mutated to alanine? * 1/1 Nothing they will bind normally The hydrogen bond will no longer be formed, and the protein will be misfolded Nothing, they will form a hydrophobic interaction They will form a disulfide bond An elderly patient is diagnosed with Alzheimer’s Disease. Which of the following is most likely the cause of this neurological disorder? * 1/1 Disulfide bond formation by cysteine amino acids Iron deficiency Aggregation of hydrophobic amino acids Ionic bonds formed by hydrogen bonding of amino acids What type of bond is found in the primary structure of a protein? * 1/1 Ionic Disulfide Charged Peptide