N5334 Final v7
Prescribing basics - correct answer✔ ✔
v7 v7 v7 v7
Prescribing is regulated by state BON
v7 v7 v7 v7 v7
Proper RX - correct answer✔ ✔
v7 v7 v7 v7
Providers name and address, Telephone
v7 v7 v7 v7
DEA
Pt name/DOB/Addres
v7
Name of Drug, strength, SIG(directions) with indication/Route
v7 v7 v7 v7 v7 v7
and frequency, Quantity and signature.
v7 v7 v7 v7 v7
Drug Schedules: Most addictive to least - correct answer✔
v7 v7 v7 v7 v7 v7 v7 v7
✔ 1: Heroin,LSD, MJ
v7 v7
2: hydrocodone, cocaine, Methamphetamine, methadone, oxyc
v7 v7 v7 v7 v7
odone, meperidine, fentanyl, adderall, ritalin
v7 v7 v7 v7
3: codeine, ketamine, testosterone
v7 v7 v7
4: xanax, valium, soma, ambient, tramadol
v7 v7 v7 v7 v7
5: antidiarrheal, antitussives, lomotil, lyrica
v7 v7 v7 v7
,Pharmicodyamics - correct answer✔ ✔ v7 v7 v7
The effects of drug on the body. Receptors are large molec
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ules usually proteins, that interact and mediate the action of d
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
rugs
agonist - correct answer✔ ✔
v7 v7 v7
produce receptor stimulation and a conformational change e
v7 v7 v7 v7 v7 v7 v7
very time they bind. Do not need all available receptors to pr
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
oduce a maximum response
v7 v7 v7
Partial agonist - correct answer✔ ✔
v7 v7 v7 v7
drugs that have properties in b/w those of full agonist and
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
antagonist. They bind to receptors but when they occupy the
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
receptor sites, they stimulate only some of the receptors.
v7 v7 v7 v7 v7 v7 v7 v7
antagonist - correct answer✔ ✔
v7 v7 v7
drugs with affinity for a receptor but with no intrinsic activ
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ity. Affinity allows the antagonist to bind to receptors, but la
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ck of intrinsic activity prevents the bound antagonist from ca
v7 v7 v7 v7 v7 v7 v7 v7 v7
using receptor activation. The block action of drugs (ex. Narc
v7 v7 v7 v7 v7 v7 v7 v7 v7
an)
,Bioavailabity - correct answer✔ ✔ v7 v7 v7
% of administered dosage of the drug that survives the first
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
pass through the liver and reaches the blood stream
v7 v7 v7 v7 v7 v7 v7 v7 v7
half life - correct answer✔ ✔
v7 v7 v7 v7
Time required for the amount of a drug in the body to decl
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ine by 50%, drugs with shorter half lives must be administer
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
frequently. 4.5- v7
5.5 times the half life to get steady state and to be limited fr
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
om the body
v7 v7
what the body does to the drug - correct answer✔ ✔
v7 v7 v7 v7 v7 v7 v7 v7 v7
absorption, distribution, metabolism, excretion v7 v7 v7
Distribution - correct answer✔ ✔ v7 v7 v7
movement of absorbed drug in bodily fluids throughout the
v7 v7 v7 v7 v7 v7 v7 v7 v7
body to target tissue. Properties affecting: lipid/water solubilit
v7 v7 v7 v7 v7 v7 v7
y, PH affects ionization of drug, protein binding, size of mol
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ecule (smaller molecules are more able to diffuse)
v7 v7 v7 v7 v7 v7 v7
Tissue: fat, bone, blood/brain barrier (only lipid soluble will
v7 v7 v7 v7 v7 v7 v7 v7 v7
pass), placental barrier (many drugs can pass)
v7 v7 v7 v7 v7 v7
, Protein binding - correct answer✔ ✔
v7 v7 v7 v7
unbound drug is free which is active, crosses membrane. L
v7 v7 v7 v7 v7 v7 v7 v7 v7
ow plasma proteins result in more free drug. Competition: wh
v7 v7 v7 v7 v7 v7 v7 v7 v7
en 2 highly bound drugs are given it increases the level of b
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
oth drugs v7
Metabolism - correct answer✔ ✔ v7 v7 v7
take place in the liver mostly. Chemical change of a drug s
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
tructure to: v7 v7
Enhance excretion, inactivate the drug, increase therapeutic ac
v7 v7 v7 v7 v7 v7 v7
tion, active a prodrug (inactive until metabolized in the body
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
into the active compound, ex: levodopa), increase or decrease
v7 v7 v7 v7 v7 v7 v7 v7 v
7toxicity
CYP450 - correct answer✔ ✔ v7 v7 v7
enzymes constitutes the most important of the phase I meta
v7 v7 v7 v7 v7 v7 v7 v7 v7
bolizing enzymes (account for about 75% of drug metabolism
v7 v7 v7 v7 v7 v7 v7 v7
in the liver)
v7 v7 v7
Phase 2: conjugation reaction occur leading to large increases
v7 v7 v7 v7 v7 v7 v7 v7 v
in hydrophilicity of the substrates rendering them more readil
7 v7 v7 v7 v7 v7 v7 v7 v7
y excretable
v7
Prescribing basics - correct answer✔ ✔
v7 v7 v7 v7
Prescribing is regulated by state BON
v7 v7 v7 v7 v7
Proper RX - correct answer✔ ✔
v7 v7 v7 v7
Providers name and address, Telephone
v7 v7 v7 v7
DEA
Pt name/DOB/Addres
v7
Name of Drug, strength, SIG(directions) with indication/Route
v7 v7 v7 v7 v7 v7
and frequency, Quantity and signature.
v7 v7 v7 v7 v7
Drug Schedules: Most addictive to least - correct answer✔
v7 v7 v7 v7 v7 v7 v7 v7
✔ 1: Heroin,LSD, MJ
v7 v7
2: hydrocodone, cocaine, Methamphetamine, methadone, oxyc
v7 v7 v7 v7 v7
odone, meperidine, fentanyl, adderall, ritalin
v7 v7 v7 v7
3: codeine, ketamine, testosterone
v7 v7 v7
4: xanax, valium, soma, ambient, tramadol
v7 v7 v7 v7 v7
5: antidiarrheal, antitussives, lomotil, lyrica
v7 v7 v7 v7
,Pharmicodyamics - correct answer✔ ✔ v7 v7 v7
The effects of drug on the body. Receptors are large molec
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ules usually proteins, that interact and mediate the action of d
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
rugs
agonist - correct answer✔ ✔
v7 v7 v7
produce receptor stimulation and a conformational change e
v7 v7 v7 v7 v7 v7 v7
very time they bind. Do not need all available receptors to pr
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
oduce a maximum response
v7 v7 v7
Partial agonist - correct answer✔ ✔
v7 v7 v7 v7
drugs that have properties in b/w those of full agonist and
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
antagonist. They bind to receptors but when they occupy the
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
receptor sites, they stimulate only some of the receptors.
v7 v7 v7 v7 v7 v7 v7 v7
antagonist - correct answer✔ ✔
v7 v7 v7
drugs with affinity for a receptor but with no intrinsic activ
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ity. Affinity allows the antagonist to bind to receptors, but la
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ck of intrinsic activity prevents the bound antagonist from ca
v7 v7 v7 v7 v7 v7 v7 v7 v7
using receptor activation. The block action of drugs (ex. Narc
v7 v7 v7 v7 v7 v7 v7 v7 v7
an)
,Bioavailabity - correct answer✔ ✔ v7 v7 v7
% of administered dosage of the drug that survives the first
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
pass through the liver and reaches the blood stream
v7 v7 v7 v7 v7 v7 v7 v7 v7
half life - correct answer✔ ✔
v7 v7 v7 v7
Time required for the amount of a drug in the body to decl
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ine by 50%, drugs with shorter half lives must be administer
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
frequently. 4.5- v7
5.5 times the half life to get steady state and to be limited fr
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
om the body
v7 v7
what the body does to the drug - correct answer✔ ✔
v7 v7 v7 v7 v7 v7 v7 v7 v7
absorption, distribution, metabolism, excretion v7 v7 v7
Distribution - correct answer✔ ✔ v7 v7 v7
movement of absorbed drug in bodily fluids throughout the
v7 v7 v7 v7 v7 v7 v7 v7 v7
body to target tissue. Properties affecting: lipid/water solubilit
v7 v7 v7 v7 v7 v7 v7
y, PH affects ionization of drug, protein binding, size of mol
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
ecule (smaller molecules are more able to diffuse)
v7 v7 v7 v7 v7 v7 v7
Tissue: fat, bone, blood/brain barrier (only lipid soluble will
v7 v7 v7 v7 v7 v7 v7 v7 v7
pass), placental barrier (many drugs can pass)
v7 v7 v7 v7 v7 v7
, Protein binding - correct answer✔ ✔
v7 v7 v7 v7
unbound drug is free which is active, crosses membrane. L
v7 v7 v7 v7 v7 v7 v7 v7 v7
ow plasma proteins result in more free drug. Competition: wh
v7 v7 v7 v7 v7 v7 v7 v7 v7
en 2 highly bound drugs are given it increases the level of b
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
oth drugs v7
Metabolism - correct answer✔ ✔ v7 v7 v7
take place in the liver mostly. Chemical change of a drug s
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
tructure to: v7 v7
Enhance excretion, inactivate the drug, increase therapeutic ac
v7 v7 v7 v7 v7 v7 v7
tion, active a prodrug (inactive until metabolized in the body
v7 v7 v7 v7 v7 v7 v7 v7 v7 v7
into the active compound, ex: levodopa), increase or decrease
v7 v7 v7 v7 v7 v7 v7 v7 v
7toxicity
CYP450 - correct answer✔ ✔ v7 v7 v7
enzymes constitutes the most important of the phase I meta
v7 v7 v7 v7 v7 v7 v7 v7 v7
bolizing enzymes (account for about 75% of drug metabolism
v7 v7 v7 v7 v7 v7 v7 v7
in the liver)
v7 v7 v7
Phase 2: conjugation reaction occur leading to large increases
v7 v7 v7 v7 v7 v7 v7 v7 v
in hydrophilicity of the substrates rendering them more readil
7 v7 v7 v7 v7 v7 v7 v7 v7
y excretable
v7
