ADVANCED PATHOPHYSIOLOGY- UTMB 5355 EXAM 1
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EXAM
A member of the health care team is researching the
etiology and pathogenesis of a number of clients who are
under his care in a hospital context. Which of the following
aspects of clients' situations best characterizes
pathogenesis rather than etiology?
-A client who has been exposed to the mycobacterium
tuberculosis bacterium
-A client who has increasing serum ammonia levels due to
liver cirrhosis
-A client who was admitted with the effects of methyl
alcohol poisoning
-A client with multiple skeletal injuries secondary to a
motor vehicle accident - Answers-A client who has
increasing serum ammonia levels due to liver cirrhosis
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A 60 year-old man has presented to a clinic and is
requesting screening for tumor markers after reading
about them in a magazine. What can the clinician most
accurately tell the man about the clinical use of tumor
markers?
-"Tumor markers are a very useful screening tool, but they
only exist for a very few types of cancer."
-"Tests for the presence of tumor markers are limited by
the fact that they are only accurate in the very early stages
of cancer."
-"Tumor markers are an excellent screening tool, but it's
only practical to test for those cancers that you're at risk
of."
-"Tumor markers alone aren't enough to confirm whether
you have cancer or not, so they're not a very useful
screening tool." - Answers--"Tumor markers alone aren't
enough to confirm whether you have cancer or not, so
they're not a very useful screening tool."
Which target of both chemotherapy and radiation
treatment accounts for adverse as well as therapeutic
effects?
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-Cell-surface receptors
-Circulating hormone levels
-Blood vessels
-Rapidly proliferating cells - Answers-Rapidly proliferating
cells
A 41-year-old female with a family history of breast cancer
has had a baseline mammogram. She states that she
performs monthly self-breast exams but really has a hard
time evaluating her lumps since she has numerous cysts.
At her annual mammogram, the technician views a
suspicious area and refers her to the radiologist. She asks
the nurse in the office, "How can a lump appear so
quickly?" The nurse's response is based on which of the
following principles?
-A tumor is undetectable until it has doubled 30 times and
contains at least 1 billion cells.
-Many tumor cells never leave the M-phase of the cell
cycle.
-Cancer cells are undifferentiated and come in various
shapes and sizes.
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-If the breast has a lot of cysts, then the fluid within those
sacs makes it difficult to feel the hard lumps of a cancer. -
Answers--A tumor is undetectable until it has doubled 30
times and contains at least 1 billion cells.
A 77-year-old male client with a diagnosis of stomach
cancer has been found to have metastases in his liver.
The client and his family are surprised at this turn of
events, stating that they do not see how he could have
developed cancer in his liver. Which of the following facts
would underlie the reply that the care team provides?
-The parenchymal tissue of the liver is particularly
susceptible to secondary malignancies.
-The portal circulatory system brings venous blood from
the GI tract into the liver.
-Hepatic stromal tissue shares characteristics with
cancerous cells, including lack of anchorage dependence.
-The proximity of the liver to the stomach allows for direct
spread of cancerous cells due to a lack of contact
inhibition. - Answers--The portal circulatory system brings
venous blood from the GI tract into the liver.