Medical Physiology (23rd edition) by Kim
Barrett, Heddwen Brooks, Scott Boitano and
Susan Barman.
National Board–Style MCQs with 100%
Correct Answers and Explanations
Volume IV – Chapter 27-40.
,Chapter 27 – Digestion, Absorption & Nutritional Principles
1. The major site for digestion and absorption of nutrients is the:
A. Stomach
B. Duodenum
C. Jejunum
D. Ileum
E. Colon
✅ Answer: C
Explanation:
The jejunum is the primary site for nutrient digestion and absorption.
2. Carbohydrate digestion begins in the:
A. Stomach
B. Duodenum
C. Mouth
D. Jejunum
E. Ileum
✅ Answer: C
Explanation:
Salivary α-amylase initiates carbohydrate digestion in the mouth.
3. The final digestion of carbohydrates into monosaccharides occurs at the:
A. Stomach
B. Pancreas
C. Brush border of intestinal epithelial cells
D. Colon
E. Liver
✅ Answer: C
Explanation:
Disaccharidases on the brush border complete carbohydrate digestion.
,4. Glucose and galactose are absorbed by intestinal cells via:
A. Facilitated diffusion
B. Passive diffusion
C. Na⁺-dependent cotransport (SGLT-1)
D. GLUT-2
E. Endocytosis
✅ Answer: C
Explanation:
Glucose and galactose use SGLT-1, a Na⁺-dependent cotransporter.
5. Fructose absorption occurs via:
A. SGLT-1
B. GLUT-4
C. GLUT-5
D. GLUT-2
E. Na⁺-ATPase
✅ Answer: C
Explanation:
Fructose is absorbed by facilitated diffusion via GLUT-5.
6. Proteins are absorbed mainly as:
A. Free amino acids only
B. Tripeptides only
C. Dipeptides and tripeptides
D. Whole proteins
E. Polypeptides
✅ Answer: C
Explanation:
Most proteins are absorbed as dipeptides and tripeptides via H⁺-dependent transporters.
, 7. The enzyme responsible for initial protein digestion is:
A. Trypsin
B. Chymotrypsin
C. Pepsin
D. Elastase
E. Carboxypeptidase
✅ Answer: C
Explanation:
Pepsin initiates protein digestion in the stomach.
8. Trypsinogen is activated to trypsin by:
A. Pepsin
B. Enterokinase (enteropeptidase)
C. Chymotrypsin
D. Gastrin
E. Secretin
✅ Answer: B
Explanation:
Enterokinase in the duodenal mucosa activates trypsinogen.
9. Fat digestion mainly requires:
A. Pancreatic amylase
B. Gastric lipase
C. Bile salts and pancreatic lipase
D. Pepsin
E. Brush border enzymes
✅ Answer: C
Explanation:
Bile salts emulsify fats, and pancreatic lipase digests triglycerides.