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Serotonin Syndrome - 🧠 ANSWER ✔✔*Similar to NMS but caused by
serotinergic medications, and has HYPERreflexive muscle activity and clonus
*onset <12h
*caused by combination of serotinergic drugs or overdose on one drug
*treated with Cyproheptadine if drug withdrawal does not produce symptom
improvement
,Malignant hyperthermia - 🧠 ANSWER ✔✔*most common triggering agents =
volatile anesthetic gases, such as halothane, sevoflurane, desflurane, isoflurane,
enflurane
OR
*depolarizing muscle relaxants suxamethonium and decamethonium used
primarily in general anesthesia
-->Remember!! Sux absolutely contraindicated in hyperkalemia
ADH - 🧠 ANSWER ✔✔antidiuretic hormone (vasopressin)
-causes migration of aquaporins
-controls WATER concentration
Aldosterone - 🧠 ANSWER ✔✔-controls sodium/potassium concentration and
hydrogen ion secretion
,Diabetes (Type I) - 🧠 ANSWER ✔✔*Most common in adolescents by may occur
in adulthood, often following viral illness
*Selective autoimmune mediated destruction of the pancreatic Beta cells resulting
in absolute lack of insulin production.
-will not have C- peptide present in blood--substance produced when pro-insulin is
cleaved to form active insulin
*strongly associated with human leukocyte antigens with Islet cell antibodies
found in approximately 90% of patients within 1st year of diagnosis
*Marked by development of ketosis d/t absolute lack of insulin
-causes body to break down fatty acids for energy production
S/S of Type I Diabetes - 🧠 ANSWER ✔✔*3Ps: Polyuria, Polydipsia, Polyphagia
-nocturnal enuresis
-weight loss
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, -weakness/fatigue
differential for unplanned weight loss - 🧠 ANSWER ✔✔-DM1
-cancer
-hyperthyroidism
-HIV
-TB
Lab/Diagnostics of Type I DM - 🧠 ANSWER ✔✔Random plasma glucose >200
Serum fasting blood sugar >126 on 2 separate occasions
ketonemia or ketonuria or both
Impaired glucose tolerance (pre-diabetic) - 🧠 ANSWER ✔✔FBG >100 BUT < 125