age 1 of 105
INTRODUCTION TO CLINICAL PHARMACOLOGY
ACTUAL EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES || 100% GUARANTEED
PASS <RECENT VERSION>
What is the definition of clinical pharmacology?
.......Answer.........A discipline spanning the spectrum of drug
delivery, drug development, drug utilization, and drug
regulation
What are the words for the following blanks?
Clinical Pharmacology is aimed at advancing therapeutics in
humans with mechanistic understanding of drug actions _____
and drug disposition _____ .......Answer.........pharmacodynamics
and pharmacokinetics
,age 2 of 105
What is the definition of translational sciences?
.......Answer.........Knowledge acquired in animal or in silico models
of disease, ex-vivo studies in human tissues, or in vivo studies in
healthy or diseased humans is translated into effective treatment
for patients
What is the starting dose of Phase I trial? .......Answer.........one
tenth of LD50 for cancer or phytotoxins
What are the professional goals of clinical pharmacologists?
.......Answer.........Discover, develop and evaluate new medicines,
regulate their use
Optimize the use of existing medicines, find new indications
,age 3 of 105
Define the basis for variability in therapeutic and toxic
responses to medicines
What is the measurement to see whether some toxicities can be
managed and may be acceptable? .......Answer.........risk/benefit
ratio
What is the characteristic of Risk/Benefit ratio?
.......Answer.........It is contextual, which tells you it is depending on
the drug and disease that we intend to treat
For example, it is not the same to consider potentially serious
toxicity for a drug intended to treat HYT, which is a medical
condition that needs lifelong therapy, compared to treatment of
cancer, a disease that is potentially lethal over the short term,
and that requires very intense treatment with combination of
drugs that have very significant toxicity
, age 4 of 105
_____ is a condition or brings up situations, if you will, where an
underlying genetic variant may predispose individuals to severe
toxicity to drugs .......Answer.........Genetics
What is the name of genetic variant and the name of antiviral
drug?
Individuals that carry _____ variant are at very high risk of
_____ hypersensitivity. This drug is used in the treatment of HIV
infections and AIDS, and prior to instituting treatment with the
drug, every pt is first tested for this variant, _____, and
alternatives must be found if the patient have the variant
.......Answer.........HLA-B*5701 and abacavir
INTRODUCTION TO CLINICAL PHARMACOLOGY
ACTUAL EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES || 100% GUARANTEED
PASS <RECENT VERSION>
What is the definition of clinical pharmacology?
.......Answer.........A discipline spanning the spectrum of drug
delivery, drug development, drug utilization, and drug
regulation
What are the words for the following blanks?
Clinical Pharmacology is aimed at advancing therapeutics in
humans with mechanistic understanding of drug actions _____
and drug disposition _____ .......Answer.........pharmacodynamics
and pharmacokinetics
,age 2 of 105
What is the definition of translational sciences?
.......Answer.........Knowledge acquired in animal or in silico models
of disease, ex-vivo studies in human tissues, or in vivo studies in
healthy or diseased humans is translated into effective treatment
for patients
What is the starting dose of Phase I trial? .......Answer.........one
tenth of LD50 for cancer or phytotoxins
What are the professional goals of clinical pharmacologists?
.......Answer.........Discover, develop and evaluate new medicines,
regulate their use
Optimize the use of existing medicines, find new indications
,age 3 of 105
Define the basis for variability in therapeutic and toxic
responses to medicines
What is the measurement to see whether some toxicities can be
managed and may be acceptable? .......Answer.........risk/benefit
ratio
What is the characteristic of Risk/Benefit ratio?
.......Answer.........It is contextual, which tells you it is depending on
the drug and disease that we intend to treat
For example, it is not the same to consider potentially serious
toxicity for a drug intended to treat HYT, which is a medical
condition that needs lifelong therapy, compared to treatment of
cancer, a disease that is potentially lethal over the short term,
and that requires very intense treatment with combination of
drugs that have very significant toxicity
, age 4 of 105
_____ is a condition or brings up situations, if you will, where an
underlying genetic variant may predispose individuals to severe
toxicity to drugs .......Answer.........Genetics
What is the name of genetic variant and the name of antiviral
drug?
Individuals that carry _____ variant are at very high risk of
_____ hypersensitivity. This drug is used in the treatment of HIV
infections and AIDS, and prior to instituting treatment with the
drug, every pt is first tested for this variant, _____, and
alternatives must be found if the patient have the variant
.......Answer.........HLA-B*5701 and abacavir
