APHON CHEMOTHERAPY OVERVIEW
EXAM QUESTIONS WITH CORRECT
ANSWERS
dosage increase - Answer- necessary if pt has overactive enzyme that allows body to
excrete medication before it has had chance to expose itself to all intended cells
pharmacogenetics - Answer- study of how people respond to drug therapy. sequence
variants in genes encoding drug-metabolizing enzymes, drug transporters, or drug
targets
factors affecting pt response to medication - Answer- diet, kidney/liver function, infection
human development, concurrent meds, organ function, disease states on
pharmacokinetics
plasma concentration - Answer- varies from pt to pt. enhances therapeutic response
and diminish probability of toxic response
goal of chemotherapy - Answer- kill malignant cells and prevent them from
metastasizing to new sites
cytotoxic - Answer- induce cell kill
cytostatic - Answer- inhibit tumor cell growth for periods of time
cell cycle specific - Answer- most effective during specific phase of cell cycle
cell cycle non specific - Answer- effective regardless of cell phase, relies more on dose
intensity for level of effectiveness
alkylating agents - Answer- cause inaccurate replication or inhibit replication of DNA
causing cell mutation or death. Most active in resting phase (cytoxin, ifos, platinum,
topiso I)
antitumor antibiotics - Answer- non-cell cycle specific. interfere w/ DNA replication and
RNA transcription. Active in all phases
antimetabolites - Answer- mimic metabolic elements and inhibit RNA/DNA synthesis
plant alkaloids - Answer- arrest cells in metaphase and prevent spindle formation
EXAM QUESTIONS WITH CORRECT
ANSWERS
dosage increase - Answer- necessary if pt has overactive enzyme that allows body to
excrete medication before it has had chance to expose itself to all intended cells
pharmacogenetics - Answer- study of how people respond to drug therapy. sequence
variants in genes encoding drug-metabolizing enzymes, drug transporters, or drug
targets
factors affecting pt response to medication - Answer- diet, kidney/liver function, infection
human development, concurrent meds, organ function, disease states on
pharmacokinetics
plasma concentration - Answer- varies from pt to pt. enhances therapeutic response
and diminish probability of toxic response
goal of chemotherapy - Answer- kill malignant cells and prevent them from
metastasizing to new sites
cytotoxic - Answer- induce cell kill
cytostatic - Answer- inhibit tumor cell growth for periods of time
cell cycle specific - Answer- most effective during specific phase of cell cycle
cell cycle non specific - Answer- effective regardless of cell phase, relies more on dose
intensity for level of effectiveness
alkylating agents - Answer- cause inaccurate replication or inhibit replication of DNA
causing cell mutation or death. Most active in resting phase (cytoxin, ifos, platinum,
topiso I)
antitumor antibiotics - Answer- non-cell cycle specific. interfere w/ DNA replication and
RNA transcription. Active in all phases
antimetabolites - Answer- mimic metabolic elements and inhibit RNA/DNA synthesis
plant alkaloids - Answer- arrest cells in metaphase and prevent spindle formation
