Comprehensive Questions and
Solutions Graded A+
H2, Pt - Answer: Reduction of carbonyls to alcohol
- will also reduce alkenes and alkynes to alkanes
NaBH4, (EtOH, MeOH, or H2O) - Answer: Reduces aldehydes and ketones to alcohol
- creates stereoisomers
1) LAH
2) H2O - Answer: Reduces aldehydes, ketones, esters, and carboxylic acids
- reacts w/ water, has to be separate steps
RX, Mg - Answer: Creation of Grignard reagent
- creates strong electrophile
1) RMgX 2) H2O - Answer: Grignard reaction
- reduces ketone to alcohol while adding new C-C bond
- when in excess, can add two C-C bonds to carboxylic acid
1) TMSCl, Et3N 2) Grignard reaction 3) TBAF or H3O+ - Answer: Protection of alcohol while
forming Grignard, then deprotect