MTSA: Advanced Physiology Test 4
Questions and Answers NEWEST UPDATE
2025/2026 RATED 100%
A fibrin network that contains trapped blood cells and platelets is called a(n)
clot
platelets have this cell in it's lineage in common with all other blood cells
pleura potential hematopoietic cell (stem cell)
1st cell that is identified as distinctly a part of the platelet lineage
megakaryoblast
differentiation progression for platelets
stem cell => megakaryoblast => megakaryocyte =fragments into=> platelets
platelets don't have a...
nucleus
normal range for platelets
150,000 - 450,000/mL
platelet half life
8-12 days
,Cytoplasm of platelets contain
-contractile proteins
-ER and golgi
-mitochondria
-prostaglandins and thromboxin
-fibrin stabilizing factor synthesis
-growth factors
purpose of the ER and golgi apparatus in platelets
-Ca++ storage
-enzyme synthesis for platelet function and coagulation factors
types of contractile proteins found in platelets
actin, myosin, thrombosthenin
function of PG and TxA2
platelet aggregation , platelet anti-aggregation and vasoconstriction
function of fibrin stabilizing factor
stablizes fibrin threads and clot
Platelet Cell Membrane contains:
-glycoprotein coating ( prevents platelets from adhering to normal vascular endothelium)
,-phospholipids
-receptors (allow for activation)
Definition of hemostasis
prevention of blood loss
hemostasis is achieved by these mechanisms in this order
- vascular constriction
- platelet plug formation
- blood coagulation/clot
- fibrin formation & repair of injured vessel
- clot lysis
mechanisms for vascular constriction for hemostasis
reflex vascular smooth muscle spasm, pain -> SNS reflex -> (norepinephrine, epi)vaso constriction
platelet release of TxA2
the greater the trauma the greater the....
vasoconstriction. thus....a cut shaving bleeds a lot but a severed limb....not as much as you might
think
platelet activation is caused by contact with this substance in damaged vascular endothelium
collegen
, First step of platelet plug formation
platelets swell and exude pseudopods
second step in platelet plug formation
actin, myosin, and thrombosthenin contract = release of clotting factors.
third step in platelet plug formation
platelets become sticky, aggregate, and adhere to collagen and von Willebrand factor in blood vessel
wall
fourth step in platelet plug formation
ADP and TxA2 secretion activates other platelets
fifth step in platelet plug formation
expression of fibrinogen receptors
sixth step in platelet plug formation
fibrin threads form in plug (mesh like)
is a platelet plug the same as a clot?
no. platelet plugs are good for small damage but blood coagulation and clot formation are for bigger
damage.
von Willebrand factor
-produced in the vascular endothelial cells
Questions and Answers NEWEST UPDATE
2025/2026 RATED 100%
A fibrin network that contains trapped blood cells and platelets is called a(n)
clot
platelets have this cell in it's lineage in common with all other blood cells
pleura potential hematopoietic cell (stem cell)
1st cell that is identified as distinctly a part of the platelet lineage
megakaryoblast
differentiation progression for platelets
stem cell => megakaryoblast => megakaryocyte =fragments into=> platelets
platelets don't have a...
nucleus
normal range for platelets
150,000 - 450,000/mL
platelet half life
8-12 days
,Cytoplasm of platelets contain
-contractile proteins
-ER and golgi
-mitochondria
-prostaglandins and thromboxin
-fibrin stabilizing factor synthesis
-growth factors
purpose of the ER and golgi apparatus in platelets
-Ca++ storage
-enzyme synthesis for platelet function and coagulation factors
types of contractile proteins found in platelets
actin, myosin, thrombosthenin
function of PG and TxA2
platelet aggregation , platelet anti-aggregation and vasoconstriction
function of fibrin stabilizing factor
stablizes fibrin threads and clot
Platelet Cell Membrane contains:
-glycoprotein coating ( prevents platelets from adhering to normal vascular endothelium)
,-phospholipids
-receptors (allow for activation)
Definition of hemostasis
prevention of blood loss
hemostasis is achieved by these mechanisms in this order
- vascular constriction
- platelet plug formation
- blood coagulation/clot
- fibrin formation & repair of injured vessel
- clot lysis
mechanisms for vascular constriction for hemostasis
reflex vascular smooth muscle spasm, pain -> SNS reflex -> (norepinephrine, epi)vaso constriction
platelet release of TxA2
the greater the trauma the greater the....
vasoconstriction. thus....a cut shaving bleeds a lot but a severed limb....not as much as you might
think
platelet activation is caused by contact with this substance in damaged vascular endothelium
collegen
, First step of platelet plug formation
platelets swell and exude pseudopods
second step in platelet plug formation
actin, myosin, and thrombosthenin contract = release of clotting factors.
third step in platelet plug formation
platelets become sticky, aggregate, and adhere to collagen and von Willebrand factor in blood vessel
wall
fourth step in platelet plug formation
ADP and TxA2 secretion activates other platelets
fifth step in platelet plug formation
expression of fibrinogen receptors
sixth step in platelet plug formation
fibrin threads form in plug (mesh like)
is a platelet plug the same as a clot?
no. platelet plugs are good for small damage but blood coagulation and clot formation are for bigger
damage.
von Willebrand factor
-produced in the vascular endothelial cells
