NR 565 Pharmacology Week 1 Questions and answers With ccmplete solution RATED A+

NR 565 Pharmacology Week 1 Ques ons and answers
With ccmplete solu on RATED A+
Pharmacokine cs - CORRECT ANSWERS The study of drug absorp on, distribu on,
metabolism, and excre on in the body

"What the body does to the drug"



Factors that affect drug absorp on (5) - CORRECT ANSWERS Rate of dissolu on

Surface area

Blood flow

Lipid solubility

PH par oning



Factors that affect drug distribu on (4) - CORRECT ANSWERS Blood flow to ssues

Ability to exit vascular system

Blood-brain barrier

Protein-binding capacity



Pharmacodynamics - CORRECT ANSWERS The study of biochemical and physiologic effects of
drugs on the body and the molecular mechanisms by which those effects are produced

"What the body does to the drug"



Phamacodynamics: 3 mechanisms of ac on - CORRECT ANSWERS Receptor

Enzyme

Non-selec ve interac ons (i.e. chemo)



Types of drug therapy (7) - CORRECT ANSWERS Acute

,Maintenance (HTN/bc)

Supplemental (insulin)

Pallia ve

Suppor ve (IV fluid)

Prophylac c

Empirical (broad-spectrum abx)



Idiosyncra c Effect - CORRECT ANSWERS Unexpected response to medica on



Tolerance - CORRECT ANSWERS Declining response to a drug



Dependence - CORRECT ANSWERS Physiological/psychological need for a drug; needs drug for
normal func on



Addic on - CORRECT ANSWERS Compulsive use of a drug despite nega ve/dangerous effects



Drug interac ons: drug-drug - CORRECT ANSWERS When 2 drugs compete for metabolizing
enzymes



Drug interac ons: food-drug - CORRECT ANSWERS Grapefruit juice or leafy greens



Drug interac ons: addi ve - CORRECT ANSWERS 1+1 = 2; both provide intended effect



Drug interac ons: antagonis c - CORRECT ANSWERS 1+1 = <2; less than desired effect of one
or both drugs

, Drug interac ons: synergis c - CORRECT ANSWERS 1+1 = >2; sum total effect is greater than if
given alone (i.e. lisinopril + HCTZ)



Drug interac ons: incompa bility - CORRECT ANSWERS 1+1 does not equal 2; two IV drugs
given together causing decomposi on of one or both drugs



8 rights of medica on administra on - CORRECT ANSWERS Pa ent

Medica on

Dose

Route

Time

Reason

Response

Documenta on



Adverse reac ons: pharmacologic - CORRECT ANSWERS Extension of a drug's normal effect



Adverse reac ons: Allergic/hypersensi vity - CORRECT ANSWERS Exaggerated immune
response (i.e. mild itching to anaphylaxis)



Adverse reac ons: idiosyncra c - CORRECT ANSWERS Peculiar to the pa ent



Adverse reac ons: drug reac on - CORRECT ANSWERS Most complex, difficult to determine



Teratogenic effects - CORRECT ANSWERS Causes birth defects



Mutagenic effects - CORRECT ANSWERS Able to cause changes in gene c ssue