ANCC APRN Exam Questions and
Answers | Latest Version | 2025/2026 |
Correct & Verified
A patient presents with unexplained weight loss and fatigue. What lab test would you order first
to screen for thyroid dysfunction?
A. CT scan of the neck
B. T3 resin uptake
✔✔C. TSH (thyroid-stimulating hormone)
D. MRI of the brain
Which medication is first-line treatment for newly diagnosed hypertension in a non-diabetic
adult?
A. Beta-blocker
✔✔B. Thiazide diuretic
C. Calcium channel blocker
D. ACE inhibitor
What is the most appropriate intervention for a child with mild persistent asthma?
1
,A. Oral corticosteroids daily
B. Rescue inhaler as needed
✔✔C. Low-dose inhaled corticosteroid daily
D. No medications unless symptoms occur
A 67-year-old patient on warfarin has an INR of 4.5 but no signs of bleeding. What is the best
action?
✔✔A. Hold warfarin and monitor INR
B. Give vitamin K immediately
C. Continue current dose
D. Send to emergency department
Which symptom is most indicative of left-sided heart failure?
✔✔A. Dyspnea on exertion
B. Peripheral edema
C. Jugular vein distention
D. Hepatomegaly
2
,What is the primary role of an APRN in health promotion?
A. Prescribing medication
✔✔B. Educating and empowering patients
C. Referring to specialists only
D. Ordering diagnostic tests
A 45-year-old presents with RUQ pain, nausea, and positive Murphy’s sign. What is the most
likely diagnosis?
A. Gastritis
✔✔B. Cholecystitis
C. Pancreatitis
D. Appendicitis
What is the best screening test for diabetes mellitus in an asymptomatic adult?
A. Random glucose
B. Insulin level
✔✔C. Fasting plasma glucose
D. Glucose tolerance test
3
, When prescribing an SSRI for depression, which side effect should you warn the patient about
initially?
✔✔A. Nausea and GI upset
B. Weight gain within 24 hours
C. Liver failure
D. Vision loss
Which lab result supports a diagnosis of bacterial urinary tract infection?
✔✔A. Positive nitrites and leukocyte esterase
B. Protein in urine
C. Glucose in urine
D. Ketones in urine
A patient with COPD has increasing shortness of breath and wheezing. What is the next best
step?
A. Start antibiotics
✔✔B. Administer a short-acting bronchodilator
4
Answers | Latest Version | 2025/2026 |
Correct & Verified
A patient presents with unexplained weight loss and fatigue. What lab test would you order first
to screen for thyroid dysfunction?
A. CT scan of the neck
B. T3 resin uptake
✔✔C. TSH (thyroid-stimulating hormone)
D. MRI of the brain
Which medication is first-line treatment for newly diagnosed hypertension in a non-diabetic
adult?
A. Beta-blocker
✔✔B. Thiazide diuretic
C. Calcium channel blocker
D. ACE inhibitor
What is the most appropriate intervention for a child with mild persistent asthma?
1
,A. Oral corticosteroids daily
B. Rescue inhaler as needed
✔✔C. Low-dose inhaled corticosteroid daily
D. No medications unless symptoms occur
A 67-year-old patient on warfarin has an INR of 4.5 but no signs of bleeding. What is the best
action?
✔✔A. Hold warfarin and monitor INR
B. Give vitamin K immediately
C. Continue current dose
D. Send to emergency department
Which symptom is most indicative of left-sided heart failure?
✔✔A. Dyspnea on exertion
B. Peripheral edema
C. Jugular vein distention
D. Hepatomegaly
2
,What is the primary role of an APRN in health promotion?
A. Prescribing medication
✔✔B. Educating and empowering patients
C. Referring to specialists only
D. Ordering diagnostic tests
A 45-year-old presents with RUQ pain, nausea, and positive Murphy’s sign. What is the most
likely diagnosis?
A. Gastritis
✔✔B. Cholecystitis
C. Pancreatitis
D. Appendicitis
What is the best screening test for diabetes mellitus in an asymptomatic adult?
A. Random glucose
B. Insulin level
✔✔C. Fasting plasma glucose
D. Glucose tolerance test
3
, When prescribing an SSRI for depression, which side effect should you warn the patient about
initially?
✔✔A. Nausea and GI upset
B. Weight gain within 24 hours
C. Liver failure
D. Vision loss
Which lab result supports a diagnosis of bacterial urinary tract infection?
✔✔A. Positive nitrites and leukocyte esterase
B. Protein in urine
C. Glucose in urine
D. Ketones in urine
A patient with COPD has increasing shortness of breath and wheezing. What is the next best
step?
A. Start antibiotics
✔✔B. Administer a short-acting bronchodilator
4
