BIOS252 Exam 1 Study Guide 2025/2026 – Anatomy
and Physiology II with Lab – Chamberlain University
| 50+ Verified Questions with Correct Answers &
Rationales | A+ Graded
Section: Muscular System Organization
Question 1
Which connective tissue surrounds 10–100 muscle fibers, separating them into fascicles?
A: Endomysium
B: Supramysium
C: Perimysium
D: Epimysium
Correct Answer: C
Rationale: Perimysium surrounds fascicles (bundles of muscle fibers). Endomysium covers
individual fibers, epimysium covers the entire muscle, and supramysium is not a term.
Question 2
What is the correct order of muscle tissue organization from smallest to largest?
A: Fiber, myofibril, filament, fascicle, skeletal muscle
B: Filament, myofibril, fiber, fascicle, skeletal muscle
C: Myofibril, filament, fiber, fascicle, skeletal muscle
D: Fascicle, fiber, myofibril, filament, skeletal muscle
Correct Answer: B
Rationale: Muscle organization starts with filament (actin/myosin), then myofibril, fiber (single
muscle cell), fascicle, and skeletal muscle.
Question 3
What is the role of the endomysium in skeletal muscle?
A: Surrounds the entire muscle
B: Covers individual muscle fibers
C: Separates fascicles
D: Anchors tendons
Correct Answer: B
Rationale: Endomysium is a connective tissue layer covering individual muscle fibers. A, C, and
D describe epimysium, perimysium, and tendon functions, respectively.
Question 4
Which structure contains sarcomeres in a muscle fiber?
A: Sarcolemma
B: Myofibril
, C: Sarcoplasmic reticulum
D: T-tubule
Correct Answer: B
Rationale: Myofibrils are rod-like structures containing sarcomeres, the contractile units of
muscle. A, C, and D have other roles.
Question 5
What is the function of a tendon in the muscular system?
A: Covers muscle fascicles
B: Connects muscle to bone
C: Stores calcium ions
D: Transmits nerve impulses
Correct Answer: B
Rationale: Tendons connect muscle to bone for movement. A, C, and D are incorrect functions.
Question 6
What is the term for a bundle of muscle fibers?
A: Myofibril
B: Fascicle
C: Sarcomere
D: Endomysium
Correct Answer: B
Rationale: A fascicle is a bundle of muscle fibers. A A, C, and D refer to different structures.
Question 7
Which muscle type is under voluntary control?
A: Cardiac muscle
B: Smooth muscle
C: Skeletal muscle
D: Visceral muscle
Correct Answer: C
Rationale: Skeletal muscle is under voluntary control, unlike cardiac and smooth/visceral
muscle.
Question 8
What is the outermost connective tissue layer of a skeletal muscle?
A: Perimysium
B: Epimysium
C: Endomysium
D: Sarcolemma
Correct Answer: B
Rationale: Epimysium surrounds the entire muscle. A, C, and D are incorrect.
Question 9
What is the origin of a muscle?
A: Point of insertion
and Physiology II with Lab – Chamberlain University
| 50+ Verified Questions with Correct Answers &
Rationales | A+ Graded
Section: Muscular System Organization
Question 1
Which connective tissue surrounds 10–100 muscle fibers, separating them into fascicles?
A: Endomysium
B: Supramysium
C: Perimysium
D: Epimysium
Correct Answer: C
Rationale: Perimysium surrounds fascicles (bundles of muscle fibers). Endomysium covers
individual fibers, epimysium covers the entire muscle, and supramysium is not a term.
Question 2
What is the correct order of muscle tissue organization from smallest to largest?
A: Fiber, myofibril, filament, fascicle, skeletal muscle
B: Filament, myofibril, fiber, fascicle, skeletal muscle
C: Myofibril, filament, fiber, fascicle, skeletal muscle
D: Fascicle, fiber, myofibril, filament, skeletal muscle
Correct Answer: B
Rationale: Muscle organization starts with filament (actin/myosin), then myofibril, fiber (single
muscle cell), fascicle, and skeletal muscle.
Question 3
What is the role of the endomysium in skeletal muscle?
A: Surrounds the entire muscle
B: Covers individual muscle fibers
C: Separates fascicles
D: Anchors tendons
Correct Answer: B
Rationale: Endomysium is a connective tissue layer covering individual muscle fibers. A, C, and
D describe epimysium, perimysium, and tendon functions, respectively.
Question 4
Which structure contains sarcomeres in a muscle fiber?
A: Sarcolemma
B: Myofibril
, C: Sarcoplasmic reticulum
D: T-tubule
Correct Answer: B
Rationale: Myofibrils are rod-like structures containing sarcomeres, the contractile units of
muscle. A, C, and D have other roles.
Question 5
What is the function of a tendon in the muscular system?
A: Covers muscle fascicles
B: Connects muscle to bone
C: Stores calcium ions
D: Transmits nerve impulses
Correct Answer: B
Rationale: Tendons connect muscle to bone for movement. A, C, and D are incorrect functions.
Question 6
What is the term for a bundle of muscle fibers?
A: Myofibril
B: Fascicle
C: Sarcomere
D: Endomysium
Correct Answer: B
Rationale: A fascicle is a bundle of muscle fibers. A A, C, and D refer to different structures.
Question 7
Which muscle type is under voluntary control?
A: Cardiac muscle
B: Smooth muscle
C: Skeletal muscle
D: Visceral muscle
Correct Answer: C
Rationale: Skeletal muscle is under voluntary control, unlike cardiac and smooth/visceral
muscle.
Question 8
What is the outermost connective tissue layer of a skeletal muscle?
A: Perimysium
B: Epimysium
C: Endomysium
D: Sarcolemma
Correct Answer: B
Rationale: Epimysium surrounds the entire muscle. A, C, and D are incorrect.
Question 9
What is the origin of a muscle?
A: Point of insertion
