DBB Final EXAM QUESTIONS AND ANSWERS
Biotransformation of drugs in the liver often occur in two stages; phase 1 changes are ____ and include
_____ - CORRECT ANSWER✅✅✅non-synthetic; oxidation
Which of the following procedures would be used for quantifying molecules in various body fluids and
tissue extracts from known samples - CORRECT ANSWER✅✅✅radioimmunoassay
This image shows a graphical display of mutant mice performing on a locomotion task. Which mutation
has occurs and what is the explanation for locomotion differences between the control and the mutant?
- CORRECT ANSWER✅✅✅Dopamine receptor 1; mutant mouse has reduced locomotion and is less
sensitive to cocaine treatment
This pathway shows catecholamine synthesis. Enzyme A is called ______ and is considered a ______and
enzyme B is needed to produce ___ - CORRECT ANSWER✅✅✅tyrosine hydroxylase; rate limiting
step; NE
This table shows drugs that affect the DA system. Box B (SKF38393) _____ D1 receptors while box C is a
drug that ______ D2 receptors. Additionally, haloperidol can cause ______ in rodents. - CORRECT
ANSWER✅✅✅stimulates; blocks; catalepsy
Dopaminergic cell bodies in the VTA send projections to the nucleus accumbens and the amygdala via
the ____ dopamine pathway. - CORRECT ANSWER✅✅✅mesolimbic
In radio ligand binding studies, _____ represents the number of binding sites and ___ is an indication of
receptor affinity. - CORRECT ANSWER✅✅✅Bmax; Kd
Which of the following about MDMA is false? - CORRECT ANSWER✅✅✅It has definitively been
shown to produce degeneration of nerve fibers in all human users.
The least efficacious dug in this dose response curve is - CORRECT ANSWER✅✅✅aspirin
,In the passive avoidance learning paradigm, learning is demonstrated by - CORRECT
ANSWER✅✅✅increased latency to enter the dark compartment.
he pre-training administration of 8-OH-DPAT impairs memory in the one-trial fear conditioning protocol,
while injection just after training has no effect. - CORRECT ANSWER✅✅✅One interpretation of this
finding is that stimulation of hippocampal 5-HT1A receptors hyperpolarizes neurons normally activated
during memory encoding.
Epigenetic changes affect gene expression by - CORRECT ANSWER✅✅✅DNA methylation; chromatin
remodeling
Using the figure below, determine which organ would be inserted in box (4); - CORRECT
ANSWER✅✅✅liver
The sac-like structures in the presynaptic terminal are called ____ and are filled with ____ - CORRECT
ANSWER✅✅✅synaptic vesicles; NT molecules
Binding of neurotropic factors to their respective trk receptors results in the - CORRECT
ANSWER✅✅✅Reciprocal phosphorylation of the two receptor molecules
Knockout mice lacking the serotonin transporter SERT exhibit all of the following except for - CORRECT
ANSWER✅✅✅enhanced maternal behavior
Anti-migraine drugs known as trip tans act as ______ agonsist and cause ____ of blood vessels -
CORRECT ANSWER✅✅✅5HT1b/1D; constriction
After drug administration has occurs, the amount of drug in the blood tat is free to bind at specific
target sites is referred to as - CORRECT ANSWER✅✅✅bioavailability
Evidence that serotonergic abnormalities may be involved in sudden infant death syndrome comes from
studies showing that - CORRECT ANSWER✅✅✅mutant mice deficient in 5-HT2a receptors have
trouble breathing
, The area postrema and the median emencement represent area in the brain where ____ is not
complete - CORRECT ANSWER✅✅✅The BBB
Figure B is unique because - CORRECT ANSWER✅✅✅capillaries in the blood brain barrier have tight
junctions
In one study, mice that were genetically engineered to express R6/2 (Huntington's) exhibited motor
disturbance that ______over time and these mice also showed a _____ - CORRECT
ANSWER✅✅✅worsened; shortened life span
Hypertension and _____ can be treated with B-receptor agonists - CORRECT ANSWER✅✅✅anxiety
The ______ administration of oxytocin has been proposed as a treatment for autism - CORRECT
ANSWER✅✅✅intranasal
MDMA has recently been shown to improve the clinical response in patients undergoing treatment for -
CORRECT ANSWER✅✅✅PTSD
Which of the following describes the interaction of two drugs when the combined drug effects are
greater than would be predicted from that combination? - CORRECT ANSWER✅✅✅Synergism
The ionization of drugs affects absorption. In this image, aspirin (weak acid) will be ____ ionized in the
stomach compartment - CORRECT ANSWER✅✅✅less
The image below shows how aspirin (a weak acid) is ionized in different compartments of the body. If
this drug was changed to pyrimethamine ( a weak base used to treat protozoal infections such as
malaria) what would happen? Pyrimethamine would be ______ ionized in the intestinal compartment
and enter the blood stream more likely from the ___ compartment. - CORRECT ANSWER✅✅✅less;
intestine
This image shows the graphical display of mutant mice performing on a locomotion task. Which
Mutation has occurred and what is the explanation for increased locomotion - CORRECT
ANSWER✅✅✅Dopamine transporters; increased beam breaks
Biotransformation of drugs in the liver often occur in two stages; phase 1 changes are ____ and include
_____ - CORRECT ANSWER✅✅✅non-synthetic; oxidation
Which of the following procedures would be used for quantifying molecules in various body fluids and
tissue extracts from known samples - CORRECT ANSWER✅✅✅radioimmunoassay
This image shows a graphical display of mutant mice performing on a locomotion task. Which mutation
has occurs and what is the explanation for locomotion differences between the control and the mutant?
- CORRECT ANSWER✅✅✅Dopamine receptor 1; mutant mouse has reduced locomotion and is less
sensitive to cocaine treatment
This pathway shows catecholamine synthesis. Enzyme A is called ______ and is considered a ______and
enzyme B is needed to produce ___ - CORRECT ANSWER✅✅✅tyrosine hydroxylase; rate limiting
step; NE
This table shows drugs that affect the DA system. Box B (SKF38393) _____ D1 receptors while box C is a
drug that ______ D2 receptors. Additionally, haloperidol can cause ______ in rodents. - CORRECT
ANSWER✅✅✅stimulates; blocks; catalepsy
Dopaminergic cell bodies in the VTA send projections to the nucleus accumbens and the amygdala via
the ____ dopamine pathway. - CORRECT ANSWER✅✅✅mesolimbic
In radio ligand binding studies, _____ represents the number of binding sites and ___ is an indication of
receptor affinity. - CORRECT ANSWER✅✅✅Bmax; Kd
Which of the following about MDMA is false? - CORRECT ANSWER✅✅✅It has definitively been
shown to produce degeneration of nerve fibers in all human users.
The least efficacious dug in this dose response curve is - CORRECT ANSWER✅✅✅aspirin
,In the passive avoidance learning paradigm, learning is demonstrated by - CORRECT
ANSWER✅✅✅increased latency to enter the dark compartment.
he pre-training administration of 8-OH-DPAT impairs memory in the one-trial fear conditioning protocol,
while injection just after training has no effect. - CORRECT ANSWER✅✅✅One interpretation of this
finding is that stimulation of hippocampal 5-HT1A receptors hyperpolarizes neurons normally activated
during memory encoding.
Epigenetic changes affect gene expression by - CORRECT ANSWER✅✅✅DNA methylation; chromatin
remodeling
Using the figure below, determine which organ would be inserted in box (4); - CORRECT
ANSWER✅✅✅liver
The sac-like structures in the presynaptic terminal are called ____ and are filled with ____ - CORRECT
ANSWER✅✅✅synaptic vesicles; NT molecules
Binding of neurotropic factors to their respective trk receptors results in the - CORRECT
ANSWER✅✅✅Reciprocal phosphorylation of the two receptor molecules
Knockout mice lacking the serotonin transporter SERT exhibit all of the following except for - CORRECT
ANSWER✅✅✅enhanced maternal behavior
Anti-migraine drugs known as trip tans act as ______ agonsist and cause ____ of blood vessels -
CORRECT ANSWER✅✅✅5HT1b/1D; constriction
After drug administration has occurs, the amount of drug in the blood tat is free to bind at specific
target sites is referred to as - CORRECT ANSWER✅✅✅bioavailability
Evidence that serotonergic abnormalities may be involved in sudden infant death syndrome comes from
studies showing that - CORRECT ANSWER✅✅✅mutant mice deficient in 5-HT2a receptors have
trouble breathing
, The area postrema and the median emencement represent area in the brain where ____ is not
complete - CORRECT ANSWER✅✅✅The BBB
Figure B is unique because - CORRECT ANSWER✅✅✅capillaries in the blood brain barrier have tight
junctions
In one study, mice that were genetically engineered to express R6/2 (Huntington's) exhibited motor
disturbance that ______over time and these mice also showed a _____ - CORRECT
ANSWER✅✅✅worsened; shortened life span
Hypertension and _____ can be treated with B-receptor agonists - CORRECT ANSWER✅✅✅anxiety
The ______ administration of oxytocin has been proposed as a treatment for autism - CORRECT
ANSWER✅✅✅intranasal
MDMA has recently been shown to improve the clinical response in patients undergoing treatment for -
CORRECT ANSWER✅✅✅PTSD
Which of the following describes the interaction of two drugs when the combined drug effects are
greater than would be predicted from that combination? - CORRECT ANSWER✅✅✅Synergism
The ionization of drugs affects absorption. In this image, aspirin (weak acid) will be ____ ionized in the
stomach compartment - CORRECT ANSWER✅✅✅less
The image below shows how aspirin (a weak acid) is ionized in different compartments of the body. If
this drug was changed to pyrimethamine ( a weak base used to treat protozoal infections such as
malaria) what would happen? Pyrimethamine would be ______ ionized in the intestinal compartment
and enter the blood stream more likely from the ___ compartment. - CORRECT ANSWER✅✅✅less;
intestine
This image shows the graphical display of mutant mice performing on a locomotion task. Which
Mutation has occurred and what is the explanation for increased locomotion - CORRECT
ANSWER✅✅✅Dopamine transporters; increased beam breaks
