NSG 6005 Advanced Pharmacology exam questions and answers fully solved
Why are nitrate-free periods every 24 hours necessary for the patient on nitroglycerin
therapy? - AnswersTo inhibit the development of tolerance
What does a low level of thyroid-stimulating hormone indicate? - AnswersHyperthroidism
What would be the best option to treat a newly diagnosed patient with a low TSH level with?
- AnswersPropanolol (Inderal)
Spironoaldactone (Aldactone) has what mechanism of action (MOA)? - AnswersAldosterone
antagonist
Heparin exerts its therapeutic action by what? - AnswersUpregulating the activity of one of
the body's natural anticoagulant molecules, antithrombin III
What physiologic action happens when the offending drug is administered during an
anaphylactic reaction. - AnswersMast cells liberate large doses of histamine.
What are two systemic psoriasis medications? - AnswersPhoto-therapy and topical
corticosteroids
What is the first choice of drug therapy for the majority of patients with uncomplicated stage
I hypertension? - AnswersThiazide diuretics
What is the effect of cardiac glycosides? - AnswersDigitalis glycosides have a negative
chronotropic effect on the cardiac muscle cells.
Amenorrhea is the most common side effect of which birth control medication? -
AnswersMedroxyprogesterone (Depo-Provera)
What is an anti-hypertensive agent which competes with epinephrine for available beta-
receptor sites? - AnswersAtenolol (Tenormin)
What type of action does nitrates have on the body? - AnswersReduction in systemic venous
tone.
What is the recommended level of low-density lipoprotein cholesterol (LDL) for patients with
known coronary artery disease? - Answers100mg/dl or less.
What is the MOA of group IV anti-dysrhythmia drugs? - AnswersDepressing phase 4
depolarization and lengthening phases 1 and 2 repolarization.
Which drug therapy should be used to lower the serum concentration of thyroid hormones
and re-establish eumetabolic state in a patient with Graves' disease? - AnswersAnti-thyroid
drugs.
, Which type of diuretic would be used for a stage I hypertension in a patient with renal
insufficiency? - AnswersLoop diuretic.
What drug should be considered as first-line therapy for a client with hypertension and heart
failure? - AnswersEnalapril (Vasotec)
Which drug is considered safe for hypertension treatment during pregnancy? -
AnswersMethyldopa (Aldomet)
What drug will reduce afterload because it is an alpha-adrenergic blocker? - AnswersPrazosin
(Minipress)
What is an expected effect of the use of a beta-adrenergic blocker to control angina? -
AnswersReduced force of cardiac contraction.
What side effect should be monitored closely in the elderly when taking Metformin
(Glucophage) for type 2 diabetes? - AnswersLactic acidosis.
What is the primary role of cytochrome p-450 in the liver? - AnswersDeactivate and detoxify
medications and other substances.
What is a component of Vitamin K-dependent clotting factors? - AnswersProthrombin
How are IV morphine and nitroglycerin beneficial in acute heart failure? - AnswersDecrease
preload.
What is the purpose of administering a vasodilating drug to a patient in heart failure? -
AnswersDecrease afterload.
What are some contrindications for HMG-co A reductase inhibitors (statins)? - AnswersThey
cause myopathies, especially at higher doses or in combination with certain drugs. They
should never be used in patients taking Warfarin (Coumadin).
Which drug can reduce serum LDL the most in patients with hyperlipidemia? -
AnswersLovastatin (Mevacor)
Which drug is contrindicated in a patient with Myasthena Gravis? - AnswersProcainamide
(Pronestyl).
What action is most effective in decreasing the risk of hyperkalemia associated with the start
of angiotensin-converting enzyme inhibitor (ACEI) therapy? - AnswersMaking sure that the
patient is well hydrated.
What factor influences plasma protein drug binding and distribution of that drug? -
AnswersThe amount of albumin available in the blood stream.
Why are nitrate-free periods every 24 hours necessary for the patient on nitroglycerin
therapy? - AnswersTo inhibit the development of tolerance
What does a low level of thyroid-stimulating hormone indicate? - AnswersHyperthroidism
What would be the best option to treat a newly diagnosed patient with a low TSH level with?
- AnswersPropanolol (Inderal)
Spironoaldactone (Aldactone) has what mechanism of action (MOA)? - AnswersAldosterone
antagonist
Heparin exerts its therapeutic action by what? - AnswersUpregulating the activity of one of
the body's natural anticoagulant molecules, antithrombin III
What physiologic action happens when the offending drug is administered during an
anaphylactic reaction. - AnswersMast cells liberate large doses of histamine.
What are two systemic psoriasis medications? - AnswersPhoto-therapy and topical
corticosteroids
What is the first choice of drug therapy for the majority of patients with uncomplicated stage
I hypertension? - AnswersThiazide diuretics
What is the effect of cardiac glycosides? - AnswersDigitalis glycosides have a negative
chronotropic effect on the cardiac muscle cells.
Amenorrhea is the most common side effect of which birth control medication? -
AnswersMedroxyprogesterone (Depo-Provera)
What is an anti-hypertensive agent which competes with epinephrine for available beta-
receptor sites? - AnswersAtenolol (Tenormin)
What type of action does nitrates have on the body? - AnswersReduction in systemic venous
tone.
What is the recommended level of low-density lipoprotein cholesterol (LDL) for patients with
known coronary artery disease? - Answers100mg/dl or less.
What is the MOA of group IV anti-dysrhythmia drugs? - AnswersDepressing phase 4
depolarization and lengthening phases 1 and 2 repolarization.
Which drug therapy should be used to lower the serum concentration of thyroid hormones
and re-establish eumetabolic state in a patient with Graves' disease? - AnswersAnti-thyroid
drugs.
, Which type of diuretic would be used for a stage I hypertension in a patient with renal
insufficiency? - AnswersLoop diuretic.
What drug should be considered as first-line therapy for a client with hypertension and heart
failure? - AnswersEnalapril (Vasotec)
Which drug is considered safe for hypertension treatment during pregnancy? -
AnswersMethyldopa (Aldomet)
What drug will reduce afterload because it is an alpha-adrenergic blocker? - AnswersPrazosin
(Minipress)
What is an expected effect of the use of a beta-adrenergic blocker to control angina? -
AnswersReduced force of cardiac contraction.
What side effect should be monitored closely in the elderly when taking Metformin
(Glucophage) for type 2 diabetes? - AnswersLactic acidosis.
What is the primary role of cytochrome p-450 in the liver? - AnswersDeactivate and detoxify
medications and other substances.
What is a component of Vitamin K-dependent clotting factors? - AnswersProthrombin
How are IV morphine and nitroglycerin beneficial in acute heart failure? - AnswersDecrease
preload.
What is the purpose of administering a vasodilating drug to a patient in heart failure? -
AnswersDecrease afterload.
What are some contrindications for HMG-co A reductase inhibitors (statins)? - AnswersThey
cause myopathies, especially at higher doses or in combination with certain drugs. They
should never be used in patients taking Warfarin (Coumadin).
Which drug can reduce serum LDL the most in patients with hyperlipidemia? -
AnswersLovastatin (Mevacor)
Which drug is contrindicated in a patient with Myasthena Gravis? - AnswersProcainamide
(Pronestyl).
What action is most effective in decreasing the risk of hyperkalemia associated with the start
of angiotensin-converting enzyme inhibitor (ACEI) therapy? - AnswersMaking sure that the
patient is well hydrated.
What factor influences plasma protein drug binding and distribution of that drug? -
AnswersThe amount of albumin available in the blood stream.
