NU 636 / NU636 Quiz 1 Complete Questions and Answers Latest Summer 2025/26.

lOMoARcPSD| NU636 Quiz 1 1. A type B adverse drug reaction (ADR) is one that is unrelated to the pharmacologic action of the drug. They are precipitated by secondary pharmacologic actions of the drug, may be unpredictable, and may or may not be dose dependent. ADRs observed by practitioners should be reported to the FDA through which program? A. Vaccine Injury Program B. NIH Clinical Trial Monitoring Program D. Patient Injury Program 2. Your patient has undergone genetic testing and found to have a CYP2D6 polymorphism poor metabolism phenotype. You know that the tricyclic anti-depressant medications are metabolized by the CYP2D6 enzyme pathway. You plan on prescribing amitriptyline for your patient for their depression. A starting dose of amitriptyline is 50 - 100mg daily at bedtime. Given the patient's poor metabolizer phenotype, which of the following doses of amitriptyline would be the appropriate dose for the patient to be started on? A. 25mg B. 500mg C. 100mg D. 200mg 3. Studies show this herb stimulates phagocytosis while increasing respiratory cellular activity and mobility of leukocytes. Uses include treatment of skin conditions and the common cold. The herb is which of the following? B. Uva Ursi C. Kava Kava D. Valerian 4. Examples of drug-disease interactions include the following except: A. Delayed gastric emptying observed with diabetic gastroparesis B. Constipation associated with irritable bowel syndrome D. Renal decline secondary to uncontrolled hypertension. 5. After a drug is administered the concept of pharmacokinetics encompasses which of the following actions on the drug? A. Drug absorption, distribution, metabolism and excretion C. Drug absorption, utilization and excretion D. Drug distribution, utilization and excretion 6. Ethnicity plays a role in both the pharmacokinetic and pharmacodynamic responses in patients. An example of this concept is A. Minimal response of Anglo-Americans to ACEI B. Minimal response of Irish-Americans to ACEI D. Minimal response of Italian Americans to ACEI A. Echinacea C. MedWatch Program C. Bowel edema and intestinal hypoperfusion from heart failure B. Drug ingestion, utilization and excretion C. Minimal response of African Americans to ACEIlOMoARcPSD| 7. The degree to which a drug is attracted to a receptor displays the level of affinity the drug has for that receptor. Not all drugs with an affinity for a receptor elicit a response. A drug with an affinity to a receptor that does not elicit a response is referred to as an: A. Pro-drug B. Agonist C. Inactive drug 8. Alcohol ingestion places a patient at great risk for CNS depression when they are concurrently taking which of the following medications? A. NSAIDS B. Muscle relaxers C. Antibiotics D. PPIs 9. A male patient comes in for evaluation of symptoms suggestive of BPH. On exam you note an enlarged, smooth prostate. His PSA is 0.7ng/ml (normal <4ng/ml). The patient reports they prefer to avoid pharmaceutical products for the condition. Honoring the patients wishes you recommend a trial of saw palmetto since it blocks the binding of DHT. Understanding the dosing of saw palmetto you recommend the following: A. 80mg BID B. 160mg daily D. 200mg BID 10. You are about to graduate from your NP program and are investigating regulation of the prescribing practices in the state you will be practicing in. Which of the following entities is the resource for the NP about prescribing practice regulation in their state? A. The Board of Pharmacy C. The Board of Healing Arts D. The Board of Pharmacology 11. Advancement in technology has facilitated increased electronic prescriptions. Sophisticated Eprescribing systems demonstrate the following advantages except: A. Evaluation for potential drug interactions C. Reduction in errors secondary to legibility D. Avoiding drugs patients are allergic to 12. There are dietary approaches that affect the metabolism of and response of drugs. An example of this would be: A. Warfarin and Vitamin D C. Warfarin and Vitamin A D. MAO inhibitors and high purine foods 13. A consortium of scientists from twenty institutions representing six countries set out to map the sequence of the human genome and the genes it contained. Access to the Human Genome downloaded by from CourseH on :47:45 GMT -05:00 Project has led to the study of inherited differences in drug metabolism and response focusing D. Antagonist C. 320 mg daily B. The Board of Nursing B. Increased patient treatment plan compliance B. MAO inhibitors and high tyramine foodslOMoARcPSD| on how the genes influence an individual’s response to drug therapy. This field of study is known as A. Pharmacodynamics B. Pharmacotherapeutics C. Pharmacokinetics 14. Prescriptions of which of the following nutrients are being provided to patients with hypertriglyceridemia? A. Krill Oil B. Omega 3 fatty acids (Fish Oil) C. Borage Oil D. Cod Liver Oil 15. For many drugs the relationship between dose and the response is straight forward where lower doses produce lower responses and higher doses produce higher responses. The correlation is based on the amount of drug occupying the receptors. However, dose response relationships depend on which of the following concepts related to drug-receptor interactions? A. Drug half-life B. Chirality C. Drug steady state D. Affinity 16. St. John’s Wort is a complementary therapy used by many for the treatment of depression and anxiety. Reportedly it inhibits the reuptake of serotonin, noradrenaline, adrenaline and dopamine. The action of St. John’s Wort is categorized the same as which of the following classes of anti-depressants? B. MAO inhibitors C. Tricyclics D. SNRIs 17. The body produces a nutrient that is essential for basic cell functioning. Levels are reported to decline with age and for those individuals who have chronic diseases. It is supplemented for patients in the treatment of hypertension, congestive heart failure and migraine headaches. What is this nutrient? A. Vitamin K2 B. Methyl cobalamin C. Co-enzyme Q10 D. Vitamin 18. Drug half-life is defined as the time required for half of the total drug amount to be eliminated from the body. According to first order kinetics how much of the drug is eliminated after three half-lives? A. 87.5% First half-life 50% of the drug is eliminated. In the second half-life 50% of the This study source was downloaded by 10r0e0m00a8i9n9i1n9g475202%froims eCliomurisneHinogni0n5g-2t1h-2e0t2o5t1a4l:4e7li:m45inGaMtTed-0d5r:0u0g to 75% and remaining A. SSRIs D. PharmacogeneticslOMoARcPSD| concentration is 25%. In the third half-life, 50% of the remaining 25% is eliminated bringing the total eliminated concentration to 87.5 and the remaining concentration is 12.5%. B. 50% C. 96.875% D. 25% 19. Melatonin is a commonly used by individuals with sleep problems as an over-the-counter aid. When taking your health history from an adult patient they report using Melatonin for sleep issues. Your knowledge of the typical dose of Melatonin for sleep leads you to anticipate the patient is taking which of the following doses for sleep? A. 20mg B. 40mg D. 100mg 20. You are caring for an elderly patient who has been experiencing mild diarrhea for the last 3 days. The patient reports they were prescribed Augmentin for treatment of sinusitis. Based on these findings you recommend which of the following? A. Addition of a stool softener B. Addition of a probiotic daily Augmentin is an antibiotic. The diarrhea in this patient is due to overgrowth of antibiotic resistant bugs in the gut. Normally, these bugs are kept in check by endogenous flora of the gut which is destroyed by the antibiotic. Probiotics promote the growth of normal gut flora which competitively inhibit the organism causing diarrhea. C. Addition of an anticholinergic D. Addition of a second antibiotic Powered by TCPDF () C. 5mg