NURS 5334 EXAM SCRIPT 2025/2026 QUESTIONS WITH
SOLUTIONS GRADED A+
✔✔first generation cephalosporin uses - ✔✔widely used for prophylaxis against
infection in surgical patients
✔✔Second generation cephalosporin uses - ✔✔cefuroxime: pneumonia from: h. flu,
klebsiella, pneumococci, and staphylococci
✔✔third generation cephalosporin uses - ✔✔gram-negative organisms
also able to penetrate to CSF - good in the treatment of meningitis
✔✔fourth generation cephalosporin uses - ✔✔commonly used to treat healthcare and
hospital-associated pneumonias, including those caused by the resistant organism
pseudomonas aeruginosa
✔✔fifth generation cephalosporin uses - ✔✔MRSA
✔✔Carbapenems - ✔✔Imipenem
Meropenem
Ertapenem
Doripenem
✔✔carbapenem uses - ✔✔beta-lactam
very broad spectrum
not active against MRSA
✔✔imipenem - ✔✔a carbapenem
active against most bacterial pathogens
gram-positive cocci and most gram-negative cocci
and bacilli
most effective beta-lactam abx for use against anaerobic bacteria
✔✔Vancomycin MOA and use - ✔✔inhibits cell wall synthesis
gram-positive infections
serious infections only - MRSA, staphylococcus epidermidis, C. Diff
✔✔Vancomycin adverse effects - ✔✔nephrotoxicity, ototoxicity, red man syndrome,
thrombophlebitis, thrombocytopenia, allergy
, ✔✔telavancin - ✔✔Lipoglycopeptide
synthetic derivatives of vancomycin
gram-positive bacteria
✔✔Telavancin Black box warning - ✔✔when treating hospital acquired or ventilator
associated pneumonia in patient with Cr clearance of <50 is associated with increased
mortality compared with vancomycin
✔✔Aztreonam - ✔✔Monobactam
binds to penicillin-binding protein 3 (PBP3)
narrow spectrum
gram-negative only
must be given parenterally
✔✔fosfomycin - ✔✔approved for single-dose therapy of uncomplicated urinary tract
infection caused by escherichia coli or enterococcus faecalis
✔✔fosfomycin side effects - ✔✔diarrhea, headache, vaginitis, nausea
✔✔tetracycline drugs - ✔✔tetracycline - short acting
demeclocycline
doxycycline - long acting
minocycline - long acting
✔✔tetracycline MOA - ✔✔inhibit protein synthesis
broad-spectrum
✔✔tetracycline uses - ✔✔acne
peptic ulcer disease
periodontal disease
rheumatoid arthritis
mycoplasma pneumoniae
lyme disease
anthrax
helicobacter pylori
✔✔tetracycline absorption - ✔✔forms chelates with calcium, iron, magnesium,
aluminum and zinc
SOLUTIONS GRADED A+
✔✔first generation cephalosporin uses - ✔✔widely used for prophylaxis against
infection in surgical patients
✔✔Second generation cephalosporin uses - ✔✔cefuroxime: pneumonia from: h. flu,
klebsiella, pneumococci, and staphylococci
✔✔third generation cephalosporin uses - ✔✔gram-negative organisms
also able to penetrate to CSF - good in the treatment of meningitis
✔✔fourth generation cephalosporin uses - ✔✔commonly used to treat healthcare and
hospital-associated pneumonias, including those caused by the resistant organism
pseudomonas aeruginosa
✔✔fifth generation cephalosporin uses - ✔✔MRSA
✔✔Carbapenems - ✔✔Imipenem
Meropenem
Ertapenem
Doripenem
✔✔carbapenem uses - ✔✔beta-lactam
very broad spectrum
not active against MRSA
✔✔imipenem - ✔✔a carbapenem
active against most bacterial pathogens
gram-positive cocci and most gram-negative cocci
and bacilli
most effective beta-lactam abx for use against anaerobic bacteria
✔✔Vancomycin MOA and use - ✔✔inhibits cell wall synthesis
gram-positive infections
serious infections only - MRSA, staphylococcus epidermidis, C. Diff
✔✔Vancomycin adverse effects - ✔✔nephrotoxicity, ototoxicity, red man syndrome,
thrombophlebitis, thrombocytopenia, allergy
, ✔✔telavancin - ✔✔Lipoglycopeptide
synthetic derivatives of vancomycin
gram-positive bacteria
✔✔Telavancin Black box warning - ✔✔when treating hospital acquired or ventilator
associated pneumonia in patient with Cr clearance of <50 is associated with increased
mortality compared with vancomycin
✔✔Aztreonam - ✔✔Monobactam
binds to penicillin-binding protein 3 (PBP3)
narrow spectrum
gram-negative only
must be given parenterally
✔✔fosfomycin - ✔✔approved for single-dose therapy of uncomplicated urinary tract
infection caused by escherichia coli or enterococcus faecalis
✔✔fosfomycin side effects - ✔✔diarrhea, headache, vaginitis, nausea
✔✔tetracycline drugs - ✔✔tetracycline - short acting
demeclocycline
doxycycline - long acting
minocycline - long acting
✔✔tetracycline MOA - ✔✔inhibit protein synthesis
broad-spectrum
✔✔tetracycline uses - ✔✔acne
peptic ulcer disease
periodontal disease
rheumatoid arthritis
mycoplasma pneumoniae
lyme disease
anthrax
helicobacter pylori
✔✔tetracycline absorption - ✔✔forms chelates with calcium, iron, magnesium,
aluminum and zinc
