NBME 10 TEST PAPER 2 2025/2026 QUESTIONS WITH
ANSWERS GRADED A+
✔✔Mechanical thrombectomy timing - ✔✔Within 24 hours of stroke presentation if
thrombus is seen
✔✔Wernicke encephalopathy triad - ✔✔AMS, ophthalmoplegia, ataxia
✔✔Mycobacterium avium lymphadenitis - ✔✔Unilateral cervical LAD with purple hue in
immunocompetent kids
✔✔RA and septic arthritis - ✔✔Increased risk of septic arthritis in RA patients
✔✔Hypocalcemia symptoms - ✔✔Perioral parathesia, carpopedal spasm, prolonged QT
✔✔Hypokalemia symptoms - ✔✔Muscle weakness, hyporeflexia, long QT, torsades de
pointes
✔✔Diabetic nephropathy - ✔✔Nonenzymatic glycosylation, Kimmelstiel-Wilson nodules,
macroalbuminuria
✔✔Venous insufficiency symptoms - ✔✔Leg swelling, ulcers, bronze discoloration,
venous varicosities
✔✔Positive PPD in HIV+ - ✔✔Induration > 5mm
✔✔OSA consequences - ✔✔Systemic and pulmonary arterial hypertension
✔✔Tramadol mechanism - ✔✔Opioid agonist with serotonin and NE reuptake effects
✔✔Mirabegron use - ✔✔B3 adrenergic receptor agonist for overactive bladder
✔✔Fetal demise screening - ✔✔Screen for medical conditions, serious US, nonstress
testing in 3rd trimester
✔✔Glucose tolerance test timing - ✔✔24 to 28 weeks in pregnancy
✔✔Fetal doppler US timing - ✔✔24 to 30 weeks in pregnancy
✔✔Amniocentesis timing - ✔✔15-18 weeks for karyotype analysis post abnormal quad
screen
✔✔Vomiting effects - ✔✔Metabolic alkalosis, decreased serum K+ and Cl-, decreased
urine Na+ and Cl-
, ✔✔Diarrhea effects - ✔✔Hyperchloremic metabolic acidosis
✔✔Diuretic use effects - ✔✔Metabolic alkalosis from intravascular volume contraction
✔✔Chi Square test use - ✔✔Compare categorical values in larger samples
✔✔Analysis of variance use - ✔✔Compare means between three or more groups
✔✔Unpaired t test use - ✔✔Calculate means difference of two unrelated groups
✔✔Paired t test use - ✔✔Calculate means difference of two related groups
✔✔Mann-Whitney test use - ✔✔Compare values between two groups with ranked data
✔✔New onset a-fib evaluation - ✔✔Check for heart failure symptoms, structural heart
disease, electrolyte disturbances
✔✔Vibrio vulnificus - ✔✔Shellfish-related diarrhea, wound infections, septicemia in
high-risk patients
✔✔Acute tubular necrosis cause - ✔✔Ischemic injury from inadequate perfusion, muddy
brown casts
✔✔Gestational trophoblastic neoplasia - ✔✔Abnormal bleeding, abdominopelvic pain,
increased beta-hcg
✔✔Anaphylaxis treatment - ✔✔Epinephrine and isotonic fluids for prompt management
✔✔TTP presentation - ✔✔Abrupt fever, anemia, thrombocytopenia, renal failure, neuro
symptoms
✔✔TTP coagulation studies - ✔✔Normal coagulation studies as it does not involve
coagulation factors
✔✔ADAMSTS13 - ✔✔Metalloprotease that cleaves vWF multimers, prevents platelet
aggregation
✔✔Persistent depressive disorder - ✔✔Long-lasting depression symptoms for at least
two years
✔✔Type III spinal muscular atrophy - ✔✔Proximal muscular weakness, normal lifespan,
wheelchair dependence
ANSWERS GRADED A+
✔✔Mechanical thrombectomy timing - ✔✔Within 24 hours of stroke presentation if
thrombus is seen
✔✔Wernicke encephalopathy triad - ✔✔AMS, ophthalmoplegia, ataxia
✔✔Mycobacterium avium lymphadenitis - ✔✔Unilateral cervical LAD with purple hue in
immunocompetent kids
✔✔RA and septic arthritis - ✔✔Increased risk of septic arthritis in RA patients
✔✔Hypocalcemia symptoms - ✔✔Perioral parathesia, carpopedal spasm, prolonged QT
✔✔Hypokalemia symptoms - ✔✔Muscle weakness, hyporeflexia, long QT, torsades de
pointes
✔✔Diabetic nephropathy - ✔✔Nonenzymatic glycosylation, Kimmelstiel-Wilson nodules,
macroalbuminuria
✔✔Venous insufficiency symptoms - ✔✔Leg swelling, ulcers, bronze discoloration,
venous varicosities
✔✔Positive PPD in HIV+ - ✔✔Induration > 5mm
✔✔OSA consequences - ✔✔Systemic and pulmonary arterial hypertension
✔✔Tramadol mechanism - ✔✔Opioid agonist with serotonin and NE reuptake effects
✔✔Mirabegron use - ✔✔B3 adrenergic receptor agonist for overactive bladder
✔✔Fetal demise screening - ✔✔Screen for medical conditions, serious US, nonstress
testing in 3rd trimester
✔✔Glucose tolerance test timing - ✔✔24 to 28 weeks in pregnancy
✔✔Fetal doppler US timing - ✔✔24 to 30 weeks in pregnancy
✔✔Amniocentesis timing - ✔✔15-18 weeks for karyotype analysis post abnormal quad
screen
✔✔Vomiting effects - ✔✔Metabolic alkalosis, decreased serum K+ and Cl-, decreased
urine Na+ and Cl-
, ✔✔Diarrhea effects - ✔✔Hyperchloremic metabolic acidosis
✔✔Diuretic use effects - ✔✔Metabolic alkalosis from intravascular volume contraction
✔✔Chi Square test use - ✔✔Compare categorical values in larger samples
✔✔Analysis of variance use - ✔✔Compare means between three or more groups
✔✔Unpaired t test use - ✔✔Calculate means difference of two unrelated groups
✔✔Paired t test use - ✔✔Calculate means difference of two related groups
✔✔Mann-Whitney test use - ✔✔Compare values between two groups with ranked data
✔✔New onset a-fib evaluation - ✔✔Check for heart failure symptoms, structural heart
disease, electrolyte disturbances
✔✔Vibrio vulnificus - ✔✔Shellfish-related diarrhea, wound infections, septicemia in
high-risk patients
✔✔Acute tubular necrosis cause - ✔✔Ischemic injury from inadequate perfusion, muddy
brown casts
✔✔Gestational trophoblastic neoplasia - ✔✔Abnormal bleeding, abdominopelvic pain,
increased beta-hcg
✔✔Anaphylaxis treatment - ✔✔Epinephrine and isotonic fluids for prompt management
✔✔TTP presentation - ✔✔Abrupt fever, anemia, thrombocytopenia, renal failure, neuro
symptoms
✔✔TTP coagulation studies - ✔✔Normal coagulation studies as it does not involve
coagulation factors
✔✔ADAMSTS13 - ✔✔Metalloprotease that cleaves vWF multimers, prevents platelet
aggregation
✔✔Persistent depressive disorder - ✔✔Long-lasting depression symptoms for at least
two years
✔✔Type III spinal muscular atrophy - ✔✔Proximal muscular weakness, normal lifespan,
wheelchair dependence
